{"id":1102,"date":"2015-10-18T23:00:00","date_gmt":"2015-10-19T04:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=839d00a403fb20f832aa5e20e0e40715"},"modified":"2015-10-18T23:00:00","modified_gmt":"2015-10-19T04:00:00","slug":"hepatic-arterial-infusion-of-low-density-lipoprotein-docosahexaenoic-acid-nanoparticles-selectively-disrupts-redox-balance-in-hepatoma-cells-and-reduces-growth-of-orthotopic-liver-tumors-in-rats","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2015\/10\/hepatic-arterial-infusion-of-low-density-lipoprotein-docosahexaenoic-acid-nanoparticles-selectively-disrupts-redox-balance-in-hepatoma-cells-and-reduces-growth-of-orthotopic-liver-tumors-in-rats\/","title":{"rendered":"Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats"},"content":{"rendered":"<p>Dietary intake of the natural omega-3 fatty acid docosahexaenoic acid (DHA) has been implicated in protecting patients with viral hepatitis B or C from developing hepatocellular carcinoma (HCC). Little is known about the effects of DHA on established solid tumors. Here we describe a low-density lipoprotein\u2212based nanoparticle that acts as a transporter for unesterified DHA (LDL\u2212DHA) and demonstrates selective\u00a0cytotoxicity toward HCC cells. We investigated the ability of LDL\u2212DHA to reduce growth of orthotopic hepatomas in rats.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dietary intake of the natural omega-3 fatty acid docosahexaenoic acid (DHA) has been implicated in protecting patients with viral hepatitis B or C from developing hepatocellular carcinoma (HCC). Little is known about the effects of DHA on established s&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2015\/10\/hepatic-arterial-infusion-of-low-density-lipoprotein-docosahexaenoic-acid-nanoparticles-selectively-disrupts-redox-balance-in-hepatoma-cells-and-reduces-growth-of-orthotopic-liver-tumors-in-rats\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5020,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1102","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/1102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5020"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=1102"}],"version-history":[{"count":1,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/1102\/revisions"}],"predecessor-version":[{"id":1380,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/1102\/revisions\/1380"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=1102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=1102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=1102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}