{"id":135418,"date":"2019-05-09T01:00:00","date_gmt":"2019-05-09T06:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=15381bbbe0a38344b99de9f3ac715c3a"},"modified":"2019-05-09T23:00:00","modified_gmt":"2019-05-10T04:00:00","slug":"amino-acid-substitutions-in-genotype-3a-hepatitis-c-virus-polymerase-protein-affect-responses-to-sofosbuvir","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2019\/05\/amino-acid-substitutions-in-genotype-3a-hepatitis-c-virus-polymerase-protein-affect-responses-to-sofosbuvir\/","title":{"rendered":"Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir"},"content":{"rendered":"<p>Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotype 3 responds slightly less well to sofosbuvir-based therapies than other genotypes. We collected data from England\u2019s National Health Service Early Access Program to search for virus factors associated with sofosbuvir treatment failure.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotype 3 responds slightly&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2019\/05\/amino-acid-substitutions-in-genotype-3a-hepatitis-c-virus-polymerase-protein-affect-responses-to-sofosbuvir\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-135418","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/135418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=135418"}],"version-history":[{"count":25,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/135418\/revisions"}],"predecessor-version":[{"id":135573,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/135418\/revisions\/135573"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=135418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=135418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=135418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}