{"id":231889,"date":"2020-10-23T19:00:00","date_gmt":"2020-10-24T00:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=94f0134a88846820a60d237afb8e4088"},"modified":"2020-10-23T23:00:00","modified_gmt":"2020-10-24T04:00:00","slug":"epithelial-tlr4-signaling-activates-duox2-to-induce-microbiota-driven-tumorigenesis","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2020\/10\/epithelial-tlr4-signaling-activates-duox2-to-induce-microbiota-driven-tumorigenesis\/","title":{"rendered":"Epithelial TLR4 signaling activates DUOX2 to induce microbiota-driven tumorigenesis"},"content":{"rendered":"<p>Chronic colonic inflammation leads to dysplasia and cancer in patients with inflammatory bowel disease (IBD). We have described the critical role of innate immune signaling via toll-like receptor 4 (TLR4) in the pathogenesis of dysplasia and cancer. In the current study, we interrogate the intersection of TLR4 signaling, epithelial redox activity, and the microbiota in colitis-associated neoplasia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chronic colonic inflammation leads to dysplasia and cancer in patients with inflammatory bowel disease (IBD). We have described the critical role of innate immune signaling via toll-like receptor 4 (TLR4) in the pathogenesis of dysplasia and cancer. In&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2020\/10\/epithelial-tlr4-signaling-activates-duox2-to-induce-microbiota-driven-tumorigenesis\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-231889","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/231889","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=231889"}],"version-history":[{"count":25,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/231889\/revisions"}],"predecessor-version":[{"id":232187,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/231889\/revisions\/232187"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=231889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=231889"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=231889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}