{"id":2569,"date":"2016-08-06T23:00:00","date_gmt":"2016-08-07T04:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=5988b8cede7809c86de5750f2f900afc"},"modified":"2016-08-06T23:00:00","modified_gmt":"2016-08-07T04:00:00","slug":"pancreatic-pre-malignant-lesions-secrete-timp1-which-activates-hepatic-stellate-cells-via-cd63-signaling-to-create-a-pre-metastatic-niche-in-the-liver","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2016\/08\/pancreatic-pre-malignant-lesions-secrete-timp1-which-activates-hepatic-stellate-cells-via-cd63-signaling-to-create-a-pre-metastatic-niche-in-the-liver\/","title":{"rendered":"Pancreatic Pre-malignant Lesions Secrete TIMP1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Pre-Metastatic Niche in the Liver"},"content":{"rendered":"<p>Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disease highly lethal. TIMP metallopeptidase inhibitor 1 (TIMP1) creates a metastasis-susceptible environment in the liver. We investigated the role of TIMP1 and its receptor CD63 in metastasis of early-stage pancreatic tumors using mice and human cell lines and tissue samples.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disease highly lethal. TIMP metallopeptidase inhibitor 1 (TIMP1) creates a metastasis-susceptible environment in the liver. We investigated the role of TIMP1 and&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2016\/08\/pancreatic-pre-malignant-lesions-secrete-timp1-which-activates-hepatic-stellate-cells-via-cd63-signaling-to-create-a-pre-metastatic-niche-in-the-liver\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2569","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/2569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=2569"}],"version-history":[{"count":1,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/2569\/revisions"}],"predecessor-version":[{"id":2571,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/2569\/revisions\/2571"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=2569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=2569"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=2569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}