{"id":274702,"date":"2021-05-02T05:00:00","date_gmt":"2021-05-02T10:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=142216deaedbfb4fd6d78b90162f8ecb"},"modified":"2021-05-02T23:00:00","modified_gmt":"2021-05-03T04:00:00","slug":"egf-and-bmps-govern-differentiation-and-patterning-in-human-gastric-glands","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2021\/05\/egf-and-bmps-govern-differentiation-and-patterning-in-human-gastric-glands\/","title":{"rendered":"EGF and BMPs govern differentiation and patterning in human gastric glands"},"content":{"rendered":"<p>The homeostasis of the gastrointestinal epithelium relies on cell regeneration and differentiation into distinct lineages organised inside glands and crypts. Regeneration depends on WNT\/\u03b2-Catenin pathway activation, but to understand homeostasis and its dysregulation in disease we need to identify the signalling microenvironment governing cell differentiation. By using gastric glands as a model, we have identified the signals inducing differentiation of surface mucus-, zymogen- and gastric acid- producing cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The homeostasis of the gastrointestinal epithelium relies on cell regeneration and differentiation into distinct lineages organised inside glands and crypts. Regeneration depends on WNT\/\u03b2-Catenin pathway activation, but to understand homeostasis and it&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2021\/05\/egf-and-bmps-govern-differentiation-and-patterning-in-human-gastric-glands\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-274702","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/274702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=274702"}],"version-history":[{"count":26,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/274702\/revisions"}],"predecessor-version":[{"id":275250,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/274702\/revisions\/275250"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=274702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=274702"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=274702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}