{"id":30086,"date":"2017-06-19T16:00:00","date_gmt":"2017-06-19T21:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=a3a3d4df5da54fb4546b88440e40fe13"},"modified":"2017-06-19T16:00:00","modified_gmt":"2017-06-19T21:00:00","slug":"treatment-of-intestinal-fibrosis-in-experimental-inflammatory-bowel-disease-by-the-pleiotropic-actions-of-a-local-rho-kinase-inhibitor-2","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2017\/06\/treatment-of-intestinal-fibrosis-in-experimental-inflammatory-bowel-disease-by-the-pleiotropic-actions-of-a-local-rho-kinase-inhibitor-2\/","title":{"rendered":"Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor"},"content":{"rendered":"<p>Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn\u2019s disease (CD). Rho kinases (ROCKs) play multiple roles in TGF\u03b2-induced myofibroblast activation that could be therapeutic targets. Because systemic ROCK inhibition causes cardiovascular side effects, we evaluated the effects of a locally acting ROCK inhibitor (AMA0825) on intestinal fibrosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn\u2019s disease (CD). Rho kinases (ROCKs) play multiple roles in TGF\u03b2-induced myofibroblast activation that could be therapeutic targets. Because systemic ROCK inhibition &#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2017\/06\/treatment-of-intestinal-fibrosis-in-experimental-inflammatory-bowel-disease-by-the-pleiotropic-actions-of-a-local-rho-kinase-inhibitor-2\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-30086","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/30086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=30086"}],"version-history":[{"count":3,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/30086\/revisions"}],"predecessor-version":[{"id":30087,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/30086\/revisions\/30087"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=30086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=30086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=30086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}