{"id":346896,"date":"2022-07-06T13:00:00","date_gmt":"2022-07-06T18:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=5c13747fc015c1ef2a2a1c3aead6aa85"},"modified":"2022-07-06T23:00:00","modified_gmt":"2022-07-07T04:00:00","slug":"using-human-induced-pluripotent-stem-cell-derived-organoids-to-identify-new-pathologies-in-patients-with-pdx1-mutations","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2022\/07\/using-human-induced-pluripotent-stem-cell-derived-organoids-to-identify-new-pathologies-in-patients-with-pdx1-mutations\/","title":{"rendered":"Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations"},"content":{"rendered":"<p>Two patients with homozygous mutations in PDX1 presented with pancreatic agenesis, chronic diarrhea and poor weight gain, the causes of which were not identified through routine clinical testing. We aim to perform a deep analysis of the stomach and intestine using organoids derived from induced pluripotent stem cells from PDX1188delC\/188delC patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two patients with homozygous mutations in PDX1 presented with pancreatic agenesis, chronic diarrhea and poor weight gain, the causes of which were not identified through routine clinical testing. We aim to perform a deep analysis of the stomach and int&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2022\/07\/using-human-induced-pluripotent-stem-cell-derived-organoids-to-identify-new-pathologies-in-patients-with-pdx1-mutations\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-346896","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/346896","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=346896"}],"version-history":[{"count":26,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/346896\/revisions"}],"predecessor-version":[{"id":347164,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/346896\/revisions\/347164"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=346896"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=346896"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=346896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}