{"id":361891,"date":"2022-11-16T16:00:00","date_gmt":"2022-11-16T21:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=8fc541ff8204fb636748ba735682f3f5"},"modified":"2022-11-16T23:00:00","modified_gmt":"2022-11-17T04:00:00","slug":"n-glycosylation-regulates-intrinsic-ifn-%ce%b3-resistance-in-colorectal-cancer-implications-for-immunotherapy","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2022\/11\/n-glycosylation-regulates-intrinsic-ifn-%ce%b3-resistance-in-colorectal-cancer-implications-for-immunotherapy\/","title":{"rendered":"N-glycosylation regulates intrinsic IFN-\u03b3 resistance in colorectal cancer: implications for immunotherapy."},"content":{"rendered":"<p>Advanced colorectal carcinoma (CRC) is characterized by a high frequency of primary immune evasion and refractoriness to immunotherapy. Given the importance of IFN-\u03b3 in CRC immunosurveillance, we investigated whether and how acquired IFN-\u03b3 resistance in tumor cells would promote tumor growth, and whether IFN-\u03b3 sensitivity could be restored.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Advanced colorectal carcinoma (CRC) is characterized by a high frequency of primary immune evasion and refractoriness to immunotherapy. Given the importance of IFN-\u03b3 in CRC immunosurveillance, we investigated whether and how acquired IFN-\u03b3 resistance i&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2022\/11\/n-glycosylation-regulates-intrinsic-ifn-%ce%b3-resistance-in-colorectal-cancer-implications-for-immunotherapy\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-361891","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/361891","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=361891"}],"version-history":[{"count":25,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/361891\/revisions"}],"predecessor-version":[{"id":362197,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/361891\/revisions\/362197"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=361891"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=361891"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=361891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}