{"id":372866,"date":"2023-05-01T10:00:00","date_gmt":"2023-05-01T15:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=0fa0c4a67c3876b6b54692be10d2918d"},"modified":"2023-05-01T22:00:00","modified_gmt":"2023-05-02T03:00:00","slug":"a-rare-presentation-of-mycophenolate-mofetil-induced-segmental-colitis-masquerading-as-ischemic-colitis","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2023\/05\/a-rare-presentation-of-mycophenolate-mofetil-induced-segmental-colitis-masquerading-as-ischemic-colitis\/","title":{"rendered":"A RARE PRESENTATION OF MYCOPHENOLATE MOFETIL-INDUCED SEGMENTAL COLITIS MASQUERADING AS ISCHEMIC COLITIS"},"content":{"rendered":"<p>Mycophenolate mofetil (MMOF) is an immunosuppressive pro-drug commonly used to prevent rejection in recipients of solid organ transplants. It is hepatically converted to mycophenolic acid which then acts to reversibly inhibit inosine monophosphate dehydrogenase, thereby preventing B and T lymphocyte proliferation, B cell antibody formation, and leukocyte recruitment to sites of inflammation. Diarrhea is the most common gastrointestinal side effect of MMOF usage with up to 40% of renal transplant patients on MMOF reporting this symptom and colonoscopy not infrequently shows injurious changes that range from edema and erythema to ulcerations and diffuse colitis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mycophenolate mofetil (MMOF) is an immunosuppressive pro-drug commonly used to prevent rejection in recipients of solid organ transplants. It is hepatically converted to mycophenolic acid which then acts to reversibly inhibit inosine monophosphate dehy&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2023\/05\/a-rare-presentation-of-mycophenolate-mofetil-induced-segmental-colitis-masquerading-as-ischemic-colitis\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-372866","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/372866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=372866"}],"version-history":[{"count":23,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/372866\/revisions"}],"predecessor-version":[{"id":373444,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/372866\/revisions\/373444"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=372866"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=372866"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=372866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}