{"id":38155,"date":"2017-12-21T01:00:00","date_gmt":"2017-12-21T06:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=32a6c43d278e0db84f41d6f9aaf52c50"},"modified":"2017-12-21T23:00:00","modified_gmt":"2017-12-22T04:00:00","slug":"efficacy-of-ns5a-inhibitors-against-hepatitis-c-virus-genotypes-1-7-and-escape-variants","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2017\/12\/efficacy-of-ns5a-inhibitors-against-hepatitis-c-virus-genotypes-1-7-and-escape-variants\/","title":{"rendered":"Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1\u20137 and Escape Variants"},"content":{"rendered":"<p>Inhibitors of the hepatitis C virus (HCV) NS5A protein are a key component of effective treatment regimens, but the genetic heterogeneity of HCV has limited the efficacy of these agents and mutations lead to resistance. We directly compared the efficacy of all clinically relevant NS5A inhibitors against HCV genotype 1\u20137 prototype isolates and resistant escape variants, and investigated the effects of pre-existing resistance-associated substitutions (RAS) on HCV escape from treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inhibitors of the hepatitis C virus (HCV) NS5A protein are a key component of effective treatment regimens, but the genetic heterogeneity of HCV has limited the efficacy of these agents and mutations lead to resistance. We directly compared the efficac&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2017\/12\/efficacy-of-ns5a-inhibitors-against-hepatitis-c-virus-genotypes-1-7-and-escape-variants\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-38155","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/38155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=38155"}],"version-history":[{"count":25,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/38155\/revisions"}],"predecessor-version":[{"id":38934,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/38155\/revisions\/38934"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=38155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=38155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=38155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}