{"id":38159,"date":"2017-12-21T01:00:00","date_gmt":"2017-12-21T06:00:00","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/richardpeek\/?guid=a0fbe5d7470f2f27a6747da36a176601"},"modified":"2017-12-21T23:00:00","modified_gmt":"2017-12-22T04:00:00","slug":"knockdown-of-anillin-actin-binding-protein-blocks-cytokinesis-in-hepatocytes-and-reduces-liver-tumor-development-in-mice-without-affecting-regeneration","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/richardpeek\/2017\/12\/knockdown-of-anillin-actin-binding-protein-blocks-cytokinesis-in-hepatocytes-and-reduces-liver-tumor-development-in-mice-without-affecting-regeneration\/","title":{"rendered":"Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice without Affecting Regeneration"},"content":{"rendered":"<p>Cytokinesis can fail during normal post-natal liver development, leading to polyploid hepatocytes. We investigated whether inhibiting cytokinesis in the liver; slows tumor growth without compromising the health of normal hepatocytes. We inhibited cytokinesis in cancer cells by knocking down anillin actin binding protein (ANLN), a cytoskeletal scaffolding protein that regulates cytokinesis and might promote tumorigenesis, in mice with liver disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cytokinesis can fail during normal post-natal liver development, leading to polyploid hepatocytes. We investigated whether inhibiting cytokinesis in the liver; slows tumor growth without compromising the health of normal hepatocytes. We inhibited cytok&#8230; <a href=\"https:\/\/my.vanderbilt.edu\/richardpeek\/2017\/12\/knockdown-of-anillin-actin-binding-protein-blocks-cytokinesis-in-hepatocytes-and-reduces-liver-tumor-development-in-mice-without-affecting-regeneration\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5910,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-38159","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/38159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/users\/5910"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/comments?post=38159"}],"version-history":[{"count":26,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/38159\/revisions"}],"predecessor-version":[{"id":38932,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/posts\/38159\/revisions\/38932"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/media?parent=38159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/categories?post=38159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/richardpeek\/wp-json\/wp\/v2\/tags?post=38159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}