Selected Publications

Poorman ME, Chaplin VL, Wilkens K, Dockery MD, Giorgio TD, Grissom WA, Caskey CF. (2016). “Open-source, small-animal magnetic resonance-guided focused ultrasound system”. J Ther Ultrasound. 4: 29.

Miller SE, Bell CS, McClain MS, Cover TL, Giorgio TD. (2016). “Dynamic Computational Model of Symptomatic Bacteremia to Inform Bacterial Separation Treatment Requirements”. PLoS ONE 11(9): e0163167. doi:10.1371/journal.pone.0163167

Miller S, Bell C, Mejias R, McClain M, Cover T, Giorgio TD. (2016). “Colistin-Functionalized Nanoparticles for the Rapid Capture of Acinetobacter baumannii”. J. Biomed. Nanotechnol., 12, 1806-1819.

Ortega RA, Barham W, Sharman K, Tikhomirov O, Giorgio TD, Yull FE. (2016). “Manipulating the NF-KB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions”. Int. J. Nanomedicine, 11, 2163–2177.

Miteva M, Kirkbride KC, Kilchrist KV, Li H, Nelson CE, Gupta MK, Giorgio TD and Duvall CL. (2015). “Tuning PEGylation of Mixed Micelles to Overcome Intracellular and Systemic siRNA Delivery Barriers”. Biomaterials, 38:97-107. [html]

Li H, Miteva M, Kirkbride K, Cheng M, Nelson C, Simpson E, Duvall CL, & Giorgio TD. (2014). “Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery”. Biomacromolecules, (in press). [html]

Pensabene V, Patel PP, Williams P, Cooper TL, Kirkbride KC, Giorgio TD, & Tulipan NB. (2014) “Repairing Fetal Membranes with a Self-adhesive Ultrathin Polymeric Film: Evaluation in Mid-gestational Rabbit Model.” Ann. of Biomed. Eng. [html]

Ortega RA, Barham WJ, Kumar B, Tikhomirov O, McFadden I, Yull FE & Giorgio TD. (2014) “Biocompatible Mannosylated Endosomal-Escape Nanoparticles Enhance Selected Delivery of Short Nucleotide Sequences to Tumor Associated Macrophages.” Nanoscale. [html]

Yu SS, Lau CM, Barham WJ, Onishko HM, Nelson CE, Li H, Smith CA, Yull FE, Duvall CL, & Giorgio TD. (2013) “Macrophage-Specific RNAi Targeting via ‘Click’, Mannosylated Polymeric Micelles.” Molecular Pharmaceutics, (in press). [html]

Li H, Yu SS, Miteva M, Nelson CE, Werfel T, Giorgio TD, & Duvall CL. (2013) “Matrix Metalloproteinase Responsive, Proximity-Activated Polymeric Nanoparticles for siRNA Delivery.” Adv Funct Mater. [html]

Evans BC, Nelson CE, Yu SS, Kim AJ, Li H, Nelson HM, Giorgio TD, & Duvall CL. (2013) “Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs.” J Visualized Exp. [html]

Ortega RA & Giorgio TD. (2012) “A mathematical model of superparamagnetic iron oxide nanoparticle magnetic behavior to guide the design of novel nanomaterials.” J Nanoparticle Res, 14 (12): 1282. [html] [pdf]

Zachman AL, Crowder SW, Ortiz O, Zienkiewicz KJ, Bronikowski CM, Yu SS, Giorgio TD, Guelcher SA, Kohn JB, & Sung HJ. (2012) “Pro-angiogenic and anti-inflammatory regulation by functional peptides loaded in polymeric implants for soft tissue regeneration.” Tissue Engineering A (in press). [html] [pdf]

Yu SS, Lau CM, Thomas SN, Jerome WG, Maron DJ, Dickerson JH, Hubbell JA, & Giorgio TD. (2012) “Size- and Charge-Dependent Non-Specific Uptake of PEGylated Nanoparticles by Macrophages.” Int J Nanomedicine, 7: 799-813. [html] [pdf]

Gupta MK, Walthal JM, Venkataraman R, Crowder SW, Jung DK, Yu SS, Feaster TK, Giorgio TD, Hong CC, Baudenbacher FJ, Hatzopoulos AK, & Sung HJ. (2011) “Combinatorial Polymer Electrospun Matrices Promote Physiologically-Relevant Cardiomyogenic Stem Cell Differentiation.” PLoS ONE, 6(12): e28935. [html] [pdf]

Yu SS, Koblin RL, Zachman AL, Perrien DS, Hofmeister LH, Giorgio TD, Sung HJ. (2011) “Physiologically-Relevant Oxidative Degradation of Oligo(proline)-Crosslinked Polymeric Scaffolds.” Biomacromolecules, 12(12): 4357–4366. [html] [pdf]

Yu SS, Ortega RA, Reagan BW, McPherson JA, Sung HJ, Giorgio TD. (2011) “Emerging Applications of Nanotechnology for the Diagnosis and Management of Vulnerable Atherosclerotic Plaques.” Wiley Interdiscip Rev Nanomed Nanobiotech, 3(6): 620-646. [html][pdf]

Sewell SL, Higgins MM, Bell CS, Giorgio TD. (2011) “Quantification of Quantum Dot Concentration using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS).” J. Biomed. Nanotech., 7(5): 685-690. [html]

Bell CS, Yu SS, Giorgio TD. (2011) “The MultiStrata Nanoparticle: A FeOx/Au Core/Shell Enveloped in a Silica-Gold Shell.”Small, 7(9): 1158-1162. [html] [pdf]

Yu SS, Scherer RL, Ortega RA, Bell CS, O’Neil CP, Hubbell JA, & Giorgio TD. (2011) “Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs).” J. Nanobiotech., 9: 7. [html] [pdf]

Thomas SN, O’Neil CP, van der Vlies AJ, Yu SS, Giorgio TD, Swartz MA, Hubbell JA. (2011) “Engineering complement activation on polypropylene sulfide vaccine nanoparticles.” Biomaterials, 32(8): 2194-2203. [html] [pdf]

Soman CP, Giorgio TD. (2009) “Sensitive and multiplexed detection of proteomic antigens via quantum dot aggregation.”Nanomedicine: Nanotechnology, Biology and Medicine, 5(4): 402-409. [pdf]

Sewell SL, Giorgio TD. (2009) “Synthesis and enzymatic cleavage of dual-ligand quantum dots.” Materials Sci & Eng C, 29: 1428-1432. [pdf]

Soman CP, Giorgio TD. (2009) “Kinetics of molecular recognition mediated nanoparticle self-assembly.” Nano Res, 2:78-84. [pdf]

Smith RA, Giorgio TD. (2008) “Quantitative measurement of multifunctional quantum dot binding to cellular targets using flow cytometry.” Cytometry A, 75(5):465-474. [html] [pdf]

Salaklang J, Steitz B, Finka A, O’Neil CP, Moniatte M, van der Vlies AJ, Giorgio TD, Hofmann H, Hubbell JA, Petri-Fink A. (2008) “Superparamagnetic nanoparticles as a powerful systems biology characterization tool in the physiological context.”Angew Chem Intl Ed, 47(41):7857-60. [html] [pdf]

Smith RA, Sewell SL, Giorgio TD. (2008) “Proximity-activated nanoparticles: in vitro performance of specific structural modification by enzymatic cleavage.” Int J Nanomedicine, 3(1): 95-103. [html] [pdf]

Soman CP, Giorgio TD. (2008) “Quantum dot self-assembly for protein detection with sub-picomolar sensitivity.”Langmuir, 24(8):4399-404. [html] [pdf]

Bírol G, McKenna AF, Smith DH, Giorgio TD, Brophy SP. (2007) “Development of Challenge-Based Educational Modules in the Biotechnology Domain.” Int J Eng Education, 23(1): 171-183. [html]

Kuhn SJ, Hallahan DE, Giorgio TD. (2006) “Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system.” Ann Biomed Eng, 34: 51-58. [html] [pdf]

Kuhn SJ, Finch SK, Hallahan DE, Giorgio TD. (2006) “Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix.” Nano Lett, 6: 306-312. [html] [pdf]

Harris SS, Giorgio TD. (2005) “Convective flow increases lipoplex delivery rate to in vitro cellular monolayers.” Gene Therapy, 12: 512-520. [html] [pdf]

Smith RA, Giorgio TD. (2004) “Quantitation and kinetics of CD51 surface receptor expression: implications for targeted delivery.” Ann Biomed Eng, 32: 635-644. [html] [pdf]

Smith RA, Giorgio TD. (2004) “Cell-based screening: a high throughput flow cytometry platform for identification of cell-specific targeting molecules.” Comb Chem High Throughput Screen, 7: 141-151. [html]

Wyatt SK, Giorgio TD. (2004) “DNA delivery to cells in culture using cationic liposomes.” Methods Mol Biol, 245: 83-94.

Giorgio TD, Wyatt SK. (2004) “DNA delivery to cells in culture using PNA clamps.” Methods Mol Biol, 245: 53-66.

Hallahan DE, Geng L, Qu C, Scarfone S, Giorgio T, Donnelly E, Gao X, Clanton J. (2003) “Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels.” Cancer Cell, 3: 63-74.

Pfeiffer S, Zorn GL, Zhang JP, Farley SM, Giorgio TD, Robson SC, Azimzadeh AM, Pierson RN. (2003) “Hyperacute lung rejection in the pig-to-human model: platelet receptor inhibitors synergistically modulate complement activation and lung injury.” Transplantation, 75: 953-959.

Banks GA, Roselli RJ, Chen R, Giorgio TD. (2003) “A model for the analysis of nonviral gene therapy.” Gene Therapy, 10: 1766-1775. [html] [pdf]

Giorgio TD, Brophy SP, Birol G, McKenna AF, Smith HD. (2002) “Assessment of educational modules based on the “How people learn” framework delivered to biotechnology learners at two universities.” Conf Proc 2nd Joint EMBS-BMES, 3: 2642-2643. [html]

Hallahan DE, Qu S, Geng L, Cmelak A, Chakravarthy A, Martin W, Scarfone C, Giorgio T. (2001) “Radiation-mediated control of drug delivery.” Am J Clin Oncol, 24: 473-480.

James M, Giorgio TD. (2000) “Nuclear-associated plasmid, but not cell-associated plasmid, is correlated with transgene expression in cultured mammalian cells.” Mol Ther 1: 339-346.

Tseng W, Haselton, FR, Giorgio TD. (1999) “Mitosis activates transgene expression of plasmid delivered by cationic liposomes.” Biochimica Biophysica Acta, 1445: 53-64.

Tseng W, Haselton, FR, Giorgio TD. (1997) “Transfection by cationic liposomes using simultaneous single cell measurements of plasmid delivery and transgene expression.” J Biol Chem, 272: 25641-25647.

Tseng W, Haselton, FR, Giorgio TD. (1997) “Transfection by cationic liposomes using simultaneous single cell measurements of plasmid delivery and transgene expression.” J Biol Chem, 272(41): 25641-25647.

Montero GA, Giorgio TD, Schnelle KB. (1997) “Supercritical fluid extraction of contaminated soil.” J Environ Sci & HealthA32: 481-495.

Tseng W, Purvis NB, Haselton FR, Giorgio TD. (1996) “Cationic liposomal delivery of plasmid to endothelial cells measured by quantitative flow cytometry.” Biotech and Bioeng, 50: 548-554.

Montero GA, Giorgio TD, Schnelle KB. (1996) “Scale-up and economic analysis for the design of supercritical fluid extraction equipment for remediation of soil.” Environ Prog, 15: 112-121.

Giorgio TD, Yek SH. (1995) “The effect of bilayer composition on calcium ion transport facilitated by fluid shear stress.”Biochimica Biophysica Acta, 1239: 39-44.

Rozga J, Morsiani E, LePage E, Moscioni AD, Giorgio T, Demetriou AA. (1994) “Isolated hepatocytes in a bioartificial liver: a single group view and experience.” Biotech and Bioeng, 43: 645-653.

Purvis NB, Giorgio TD, Stelzer GT, Shults KE. (1994) “Shear-induced platelet activation measured by flow cytometry.” Ann NY Acad Sci, 714: 309-311.

Purvis NB, Giorgio TD. (1994) “Cell size and surface area determined by flow cytometry.” Ann NY Acad Sci, 714: 306-308.

Nicholson NS, Panzer-Knodle SG, King LW, Taite BB, Keller BT, Tjoeng FS, Engleman VW, Giorgio TD, Feigen LP. (1994) “SC-49992–a potent and specific inhibitor of platelet aggregation.” Thromb Res, 74(5): 523-35.

Rozga1 J, Williams F, Ro MS, Neuzil DF, Giorgio TD, Backfisch G, Moscioni AD, Hakim R, Demetriou AA. (1993) “Development of a bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells.”Hepatology, 17(2): 258-265.



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