Aaron B. Bowman
The Bowman lab utilizes a combined approach of molecular genetics, biochemistry, cell and developmental biology to understand the role of gene-environment interactions between metal exposure and neurodegenerative diseases such as Huntington’s disease. The lab employs a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal cultures, and mouse models with the aim to define mechanisms of neuronal dysfunction and understand the basis of selective neuropathology, by characterizing the molecular function of disease genes and their interaction with environmental toxicants under both normal and pathological conditions. The lab’s primary focus is on environmental modulation of neurodegenerative disorders Parkinson’s Disease and Huntington’s Disease specifically.