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F. Peter Guengerich

F. Peter Guengerich
Harry Pearson Broquist Professor of Biochemistry
Ph.D., Vanderbilt University, 1973 (Biochemistry)

Major areas of interest include the metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA.  Several approaches are being used to understand the catalytic mechanisms of the human cytochrome P450 enzymes, including site-directed and random mutagenesis, kinetic analysis, isotope effects, and substrate-activity relationships.  One major area of interest is the identification of reactions catalyzed by the “orphan” P450s, those in humans and also Streptomyces that do not have characterized functions yet. Work on halogenated hydrocarbons is done with trichloroethylene, ethylene dibromide, and methylene dihalides and the adducts they form.  Glutathione transferase-mediated bioactivation is under investigation, as well as in the case of some bifunctional electrophiles.  Studies on the polymerases involve the use of modified oligonucleotides, steady-state and pre-steady-state kinetics, and physical approaches such as x-ray diffraction. A major goal is to understand how carcinogen-DNA adducts cause polymerases to stall and misincorporate bases.

Recent Publications

Related Links:
Research Laboratory Web Page
ISI Web of Knowledge
International Conference on Cytochrome P450

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Please note:

If you used any Center resources (i.e., facility core services, pilot project funding), please be sure to cite the Center grant:
This [project/publication] was supported [in part] by the Center in Molecular Toxicology, NIH P30 ES000267.

For work supported by the Center's training grant, please use the following citation:
This [project/publication] was supported [in part] by the Training Program in Environmental Toxicology, NIH T32 ES007028.

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