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Hijacking human proteins to better deliver anti-cancer drugs

Posted by on Monday, July 24, 2017 in News.

Powerful molecules can hitch rides on a plentiful human protein and signal tumors to self-destruct, a team of Vanderbilt University engineers found.

Their research gives oncologists a better shot at overcoming the problems of drug resistance, toxicity to patients and a host of other barriers to consistently achieving successful gene therapy for cancer. It is particularly promising for patients with triple-negative breast cancer, an aggressive type that makes up about 15-20 percent of cases.

Craig Duvall, associate professor of biomedical engineering, put the effectiveness of a specialized ribonucleic acid hitchhiking on the human protein albumin up against jetPEI nanoparticles, the mostly widely used synthetic carrier for the task of tumor gene silencing.

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