{"id":1770,"date":"2019-01-02T13:49:29","date_gmt":"2019-01-02T18:49:29","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/vinsenews\/?p=1770"},"modified":"2019-01-02T13:53:49","modified_gmt":"2019-01-02T18:53:49","slug":"colloquium-decuzzi","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/vinsenews\/2019\/01\/colloquium-decuzzi\/","title":{"rendered":"VINSE Colloquium Series: “Multifunctional Nanoconstructs in Cancer, Cardiovascular and Chronic Inflammatory Diseases\u201d Dr. Paolo Decuzzi; the Italian Institute of Technology 01\/09\/2019"},"content":{"rendered":"
January 9, 2019\r\n\r\nPaolo Decuzzi\r\n<\/strong><\/pre>\n
Laboratory of Nanotechnology for Precision Medicine \r\nItalian Institute of Technology\r\nSenior Researcher and Professor\r\nDirector, Laboratory of Nanotechnology for Precision Medicine\r\n\r\n\u201cMultifunctional Nanoconstructs in Cancer, Cardiovascular and Chronic Inflammatory Diseases\u201d<\/strong>\r\n\r\n4:10 PM, 134 Featheringill Hall<\/strong>\r\nRefreshments served at 3:45\r\n\r\n<\/pre>\n
Abstract<\/strong><\/p>\n
Multifunctional nanoconstructs are particle-based nano-scale systems designed for the \u2018smart\u2019 delivery of therapeutic and imaging agents. The Laboratory of Nanotechnology for Precision Medicine at IIT-GE synthesizes polymeric nanoconstructs with different sizes<\/em>, ranging from a few tens of nanometers to a few microns; shapes<\/em>, including spherical, cubical and discoidal; surface<\/em> properties, with positive, negative, neutral coatings; and mechanical stiffness<\/em>, varying from that of cells to rigid, inorganic materials, such as iron oxide. These are the 4S parameters<\/em> \u2013 size, shape, surface, stiffness \u2013 which can be precisely tuned in the synthesis process enabling disease- and patient-specific designs of multifunctional nanoconstructs. In this lecture, the role of manipulating these 4S parameters over different temporal and length scales will be elucidated in the context of improving particle interaction with professional phagocytic cells, blood longevity and tissue specific accumulation. Applications to cancer, cardiovascular and chronic inflammatory diseases will be discussed.<\/p>\n
Bio<\/strong><\/p>\n
Paolo Decuzzi is a senior researcher and director of the Laboratory of Nanotechnology for Precision Medicine at the Italian Institute of Technology in Genova \u2013 Italy. Dr. Decuzzi earned his Ph.D. degree in Mechanical Engineering from the University of Naples \u2013 Federico II (Italy) in 2001, with a thesis on friction and adhesion at the nanoscale. In 2002, he was nominated Assistant Professor of Machine Design at the Politecnico di Bari. In 2005, he became Associate Professor in the School of Medicine of the University \u2018Magna Graecia\u2019. There, he co-founded BioNEM – the laboratory of BioNanotechnology and Engineering for Medicine – one of the first nano-engineering laboratories built in a School of Medicine.<\/p>\n
In October 2007, he joined The University of Texas Health Science Center in Houston as an Associate Professor of Biomedical Engineering. In October 2010, he moved to the Houston Methodist Hospital where he served as a Professor of Biomedical Engineering till July 2015. There, he founded the Center for the Rational Design of Multifunctional Nanoconstructs, with the financial support of the Cancer Prevention and Research Center of Texas and the US National Cancer Institute; and served first as the co-chair of the Nanomedicine Department and then as the interim chair of the Translational Imaging Department.<\/p>\n
In July 2014, Dr. Decuzzi was awarded a 5-year European Research Council \u201cConsolidator Grant\u201d to design, synthesize and develop nanoconstructs for imaging and therapy in brain cancer.<\/p>\n
Dr. Decuzzi has been a visiting scientist at the Department of Theoretical and Applied Mechanics at the University of Michigan – Ann Arbor (1998, 1999 and 2001); and visiting professor at the Princeton Material Institute \u2013 Princeton (2003); the Heart and Lung Institute at the Ohio State University\u00a0 (2003 and 2004); the University of Texas Health Science Center (2006).<\/p>\n
Dr. Decuzzi has published over 150 papers in international peer-reviewed journals, international conferences and book chapters. He holds over 5 patents in the field of Nanomedicine. He co-founded NEMB \u2013 NanoEngineering for Medicine and Biology \u2013 committee of the American Society for Mechanical Engineers and is involved in multiple dissemination activities to foster the collaboration between biomedical scientists and engineers. He serves on multiple NIH, NSF, ESF, and Italian Government study sections and his research activity is primarily supported by NIH, DOD, CPRIT in USA; ESF and ERC in EU.<\/p>\n
Decuzzi\u2019s lab mission is to i.<\/strong> rationally design polymeric nanoconstructs for multi-modal imaging and combination therapy in cancer, cardiovascular and neurological diseases; ii.<\/strong> fabricate microfluidic chips for the rapid screening of novel molecular and nano-based therapeutic agents; iii.<\/strong> develop multi-scale, hierarchical computational models for predicting the transport and therapeutic efficacy of nanoconstructs; iv.<\/strong> organize dissemination activities at the interface between engineering and biomedical sciences; and v.<\/strong> promote the professional development of lab members in a highly multi-disciplinary environment.<\/p>\n","protected":false},"excerpt":{"rendered":"
January 9, 2019 Paolo Decuzzi Laboratory of Nanotechnology for Precision Medicine Italian Institute of Technology Senior Researcher and Professor Director, Laboratory of Nanotechnology for Precision Medicine \u201cMultifunctional Nanoconstructs in Cancer, Cardiovascular and Chronic Inflammatory Diseases\u201d 4:10 PM, 134 Featheringill Hall Refreshments served at 3:45 Abstract Multifunctional nanoconstructs are particle-based nano-scale systems designed for the \u2018smart\u2019…<\/p>\n","protected":false},"author":4798,"featured_media":1771,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,13],"tags":[23],"class_list":["post-1770","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vinse-colloquium","category-events","tag-vinse-colloquium"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/1770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/users\/4798"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/comments?post=1770"}],"version-history":[{"count":2,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/1770\/revisions"}],"predecessor-version":[{"id":1773,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/1770\/revisions\/1773"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/media\/1771"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/media?parent=1770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/categories?post=1770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/tags?post=1770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}