{"id":4365,"date":"2023-01-20T12:34:42","date_gmt":"2023-01-20T17:34:42","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/vinsenews\/?p=4365"},"modified":"2023-01-20T12:34:42","modified_gmt":"2023-01-20T17:34:42","slug":"diabetic-hyperglycemia-promotes-primary-tumor-progression-through-glycation-induced-tumor-extracellular-matrix-stiffening-published-in-science-advances-selected-as-vinse-spotlight-publication","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/vinsenews\/2023\/01\/diabetic-hyperglycemia-promotes-primary-tumor-progression-through-glycation-induced-tumor-extracellular-matrix-stiffening-published-in-science-advances-selected-as-vinse-spotlight-publication\/","title":{"rendered":"&#8220;Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening&#8221; published in Science Advances selected as VINSE Spotlight Publication"},"content":{"rendered":"<p><a href=\"https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/1669\/2023\/01\/WW_RK_2022_SA.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-4367\" src=\"https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/1669\/2023\/01\/WW_RK_2022_SA-650x296.png\" alt=\"WW_RK_2022_SA\" width=\"650\" height=\"296\" srcset=\"https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/1669\/2023\/01\/WW_RK_2022_SA-650x296.png 650w, https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/1669\/2023\/01\/WW_RK_2022_SA-300x136.png 300w, https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/1669\/2023\/01\/WW_RK_2022_SA-768x349.png 768w, https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/1669\/2023\/01\/WW_RK_2022_SA.png 1033w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/a><\/p>\n<p>About the authors: Co-first author, Wenjun Wang is an NIH NCI F99\/K00 Predoctoral Fellow in Biomedical Engineering advised by Prof. Cynthia Reinhart-King. Wenjun\u2019s research focuses on the mechanism of tumor progression at the RNA, cell, and tissue levels via alteration of tissue mechanical properties. Co-first author, Dr. Lauren Hapach earned her Ph.D. in Biomedical Engineering in 2021 under the direction of Prof. Cynthia Reinhart-King. In addition to this work, her dissertation investigated the role of intratumor heterogeneity in breast cancer metastasis. In recently published work, Wang, Hapach, and co-authors found that diabetic hyperglycemia promotes breast tumor growth, epithelial-to-mesenchymal transition (EMT) of tumor cells, and tumor extracellular matrix (ECM) stiffening through increased glycation, a non-enzymatic chemical reaction. Inhibition of glycation or the cells\u2019 ability to sense changes in tissue glycation in diabetic mice reduces these same metrics to a comparable level as control non-diabetic mice. Published in the journal <em>Science Advances, <\/em>this study describes a novel biomechanical mechanism by which hyperglycemia promotes breast tumor progression via glycation-mediated tumor ECM crosslinking and highlights the key role of ECM stiffening in the interaction between breast cancer and diabetes. This work also points to glycation inhibition as a promising potential adjuvant therapy for diabetic cancer patients.<\/p>\n<p><a href=\"https:\/\/www.vanderbilt.edu\/vinse\/sciadv.abo1673.pdf\">Read Article<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>About the authors: Co-first author, Wenjun Wang is an NIH NCI F99\/K00 Predoctoral Fellow in Biomedical Engineering advised by Prof. Cynthia Reinhart-King. Wenjun\u2019s research focuses on the mechanism of tumor progression at the RNA, cell, and tissue levels via alteration of tissue mechanical properties. Co-first author, Dr. Lauren Hapach earned her Ph.D. in Biomedical Engineering&#8230;<\/p>\n","protected":false},"author":3411,"featured_media":4367,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,35],"tags":[98,314,37,313],"class_list":["post-4365","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-spotlight-publications","tag-cindy-reinhart-king","tag-lauren-hapach","tag-spotlight-publication","tag-wenjun-wang"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/4365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/users\/3411"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/comments?post=4365"}],"version-history":[{"count":1,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/4365\/revisions"}],"predecessor-version":[{"id":4368,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/posts\/4365\/revisions\/4368"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/media\/4367"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/media?parent=4365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/categories?post=4365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/vinsenews\/wp-json\/wp\/v2\/tags?post=4365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}