November, 2018
Update: November 15, 2018
Nov. 15, 2018—Since the last progress update, we have produced a detailed design for the set of erlenmeyer flasks that will be used in the device along with finding possible sealing materials to create a sanitary and airtight seal. We have also identified the permeable filters that will be used. The next step will be to attain...
Co-culturing and Synthetic Microbiomes
Nov. 12, 2018—Shi, Y. , Pan, C. , Wang, K. , Chen, X. , Wu, X. , Chen, C. A. and Wu, B. (2017) Synthetic multispecies microbial communities reveals shifts in secondary metabolism and facilitates cryptic natural product discovery. Environ Microbiol, 19: 3606-3618. doi: 10.1111/1462-2920.13858. Kim, H. J., Lee, J., Choi, J. H., Bahinski, A., Ingber, D....
Project-Specific Importance
Nov. 12, 2018—Donovan S, M, Comstock S, S. (2017), Human Milk Oligosaccharides Influence Neonatal Mucosal and Systemic Immunity. Ann Nutr Metab 2016;69(suppl 2):41-51. doi: 10.1159/000452818 Flint, H. J., Duncan, S. H., Scott, K. P. and Louis, P. (2007), Interactions and competition within the microbial community of the human colon: links between diet and health. Environmental Microbiology, 9: 1101-1111....
Other Research Applications
Nov. 12, 2018—Wu, H., Tremaroli, V., & Bäckhed, F. (2015). Linking microbiota to human diseases: a systems biology perspective. Trends in Endocrinology & Metabolism, 26(12), 758-770. Wilson B, Rossi M, Kanno T, et al (2018), PWE-126 Low fodmap diet effect on IBS gastrointestinal microbiome and metabolites and prediction of response Gut;67:A181-A182. Zitvogel, L., Daillere, R., Roberti, M. P., Routy, B., & Kroemer,...
Update: November 6, 2018
Nov. 6, 2018—Within the past week, our group completed a literature review of relevant papers for co-culture devices for the study of microbiomes. The key papers in the field have been highlighted below. 1. Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device[1] Kim H.J. et al designed a protocol to replicate...
Update: November 1, 2018
Nov. 1, 2018—Recent progress in producing a co-culture device for microbiomes has led to preliminary computer-aided drawings (CADs) of our device design ideas. At this point in our project, we have not made a decision on whether we would like to make our device in glass petri dishes or in connected erlenmeyer flasks. Both options come with...