The Advanced Therapeutics Laboratory applies “smart”, environmentally-responsive polymers to develop novel approaches for overcoming pharmacological barriers. A variety of projects are currently underway to develop polymeric systems that respond to one or more stimuli such as pH, temperature, oxidative stress, and enzymatic activity. We also employ nucleic acid and protein engineering strategies toward development of new carrier-free genetic medicines. Technologies currently under development are aimed at tissue protection/repair, drug targeting / controlled release, and development of experimental therapeutics against currently undruggable targets. Medical application areas include cancer, wound healing and tissue regeneration, osteoarthritis, degenerative ophthalmological diseases, and reduction of procedure-associated vascular intimal hyperplasia. For more specific project information please reference the ‘Research’ tab.