Recent Articles

• Tateishi, Y., McCarty, K.D., Martin, M.V., and Guengerich, F.P. (2024, in press) ACS Catalysis. “Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4.
• Tateishi, Y., Webb, S.N., Li, B., Liu, L., Lindsey Rose, K., Leser, M., Patel, P., and Guengerich, F.P. (2024, in press) J. Biol. Chem. “Proteomics, Modeling, and Fluorescence Assays Delineate Cytochrome b₅ Residues Involved in Binding and Stimulation of Cytochrome P450 17A1 Lyase.”
• McCarty, K.D., Tateishi, Y., Hargrove, T.Y., Lepesheva, G.I., and Guengerich, F.P. (2024) Angew. Chem., Int. Ed. 320231771 “Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in Cytochrome P450 51A1 Sterol 14a-Demethylation.”
• McCarty, K.D., Liu, L., Tateishi, Y., Wapshott-Stehli, H.L., and Guengerich, F.P. (2023) J. Biol. Chem. 300, 105495. “The Multistep Oxidation of Cholesterol to Pregnenolone by Human Cytochrome P450 11A1 is Highly Processive.”
• Nagayoshi, H. Murayama, N., Kim, V., Kim, D., Takenaka, S., Yamazaki, H., Guengerich, F.P., and Shimada T. (2023) Chem. Res. Toxicol. 36, 1778-1788. “Oxidation of Naringenin, Apigenin, and Genistein by Human P450 1B.1 and Scutallaria P450 82D.1.
• Kojima, M., Machida, K., Cho, S., Watanabe, D., Seki, H., Shimoji, M., Imaoka, A., Yamazaki, H., Guengerich, F.P., Nakamura, K., Yamamoto, K., Akiyoshi, T., and Ohtani, H. (2023) Xenobiotica 53, 357-365. “The Influence of Temperature on the Metabolic Activity of CYP2C9, CYP2C19, and CYP3A4 Genetic Variants.”
• Spalenkova, A., Ehrlichova, M., Wei, S., Guengerich, F.P., and Soucek, P. (2023) J. Steroid Biochem. Mol. Biol. 232,106354. “Effects of 7-Ketocholesterol on Tamoxifen Efficacy in Breast Carcinoma Cell Line Models in vitro.”
• Glass, S.M., Tateishi, Y., Guengerich, F.P., and Wang H.-J. (2023) Arch. Biochem. Biophys 743, 109669. “3,4-Desaturation of Retinoic Acids by Cytochrome P450 27C1 Prevents P450-Mediated Catabolism.”
• McCarty, K.D., Sullivan, M.E., Tateishi, Y., Hargrove, T.Y., Lepesheva, G.I., and Guengerich, F.P. (2023) J. Biol. Chem.299, 104841. “Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1.”
• Jian, J.Y., McCarty, K.D., Byl, J.W., Guengerich, F.P., Neuman, K.C. and Osheroff, N. (2023) Nucl. Acids Res. 51, 3888-3902. “Basis for the Discrimination of Supercoil Handedness During DNA Cleavage by Human and Bacterial Type II Topoisomerases.”
• Yeom, M., Hong, J.-K., Shin, J.-H., Lee, Y., Guengerich, F.P., and Choi, J.-Y. (2023) Int. J. Mol. Sci. 24, 5198. “Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells.”
• Lee, S.-G., Kim, V., Lee, G.-H., Kim, C., Jeong, E., Guengerich, F.P., and Kim, D. (2023) J. Inorg. Biochem. 240, 112085 “Hydroxylation and Lyase Reactions of Steroids Catalyzed by Mouse Cytochrome P450 17A1 (Cyp17a1).”
• Chakraborty, S., Mallick, D., Goswami, M., Chakrabarty, A., Guengerich, F.P., and Chowdhury, G. (2022) J. Nat. Prod. 85, 2340-2350. “The Natural Products Withaferin A and Withanone from the Medicinal Herb Withania somnifera are Covalent Inhibitors of the SARS-Cov-2 Main Protease.” (Selected for Cover Art)
• Ghodke, P.P., Matse, J.H., Dawson, S., and Guengerich, F.P. (2022) Chem. Res. Toxicol. 35, 1805-1808. “Nucleophilic Thiol Proteins Bind Covalently to Abasic Sites in DNA.”
• Shimada, T., Nagayoshi, H., Murayama, N., Sawai, A., Kim, V., Kim, D., Yamazaki, H., Guengerich, F.P., and Takenaka, S. (2022) Xenobiotica 52, 134-145. “Oxidation of 3´-Methoxyflavone, 4´-Methoxyflavone, and 3´,4´-Demethoxyflavone and Their Derivatives Having 5,7-Dihydroxyl Groups by Human Cytochromes P450 1B1 and 2A13.”

Review Articles

• Rendic, S.P., and Guengerich, F.P. (2024, in press) Arch. Toxicol. “Bioactivation of Drugs to Potentially Toxic Products Catalyzed by Human Drug-Metabolizing Enzymes.”
• Guengerich, F.P. (2024, in press) Drug Metab. Dispos. “Cytochrome P450 Enzymes as Drug Targets in Human Disease.”
• Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Harman, C., and Taylor, S.V. (2024, in press) Food Technol. “Recent Progress in the Consideration of Flavoring Ingredients under the Food Additives Amendment. 29. GRAS Flavoring Substances.”
• Guengerich, F.P. (2024) J. Biol. Chem., 105625. “Reflection: Ninety-eight Semesters of Cytochrome P450 Enzymes and Related Topics—What Have I Taught and Learned?”
• Davidsen, J.M., Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Rosol T.J., and Taylor, S.V. (2023) Food Chem. Toxicol. 182, 114040. “In Response to the Letter to the Editor from Xiao Regarding Our Article “FEMA GRAS Assessment of Natural Flavor Complexes: Asafetida Oil, Garlic Oil, and Onion Oil.”
• Guengerich, F.P., Tateishi, Y., and McCarty, K.D. (2023) Med. Chem. Res. 32, 1263-1277. “Mechanisms of Cytochrome P450 Catalysis: C-C Bond Cleavage Reactions and Roles of Iron-Oxygen Complexes.
• Guengerich, F.P., McCarty, K.D., Tateishi, Y., and Liu, L., (2023) Methods Enzymol. 689, 39-63. “Steroid 17a-Hydroxylase/17,20-Lyase (Cytochrome P450 17A1).”
• Rosol, T.J., Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Davidsen, J.M., Harman, C.L., Ramanan, D., and Taylor, S.V. (2023) Food Chem. Toxicol. 175, 113697. “FEMA GRAS Assessment of Natural Flavor Complexes: Lemongrass Oil, Chamomile Oils, Citronella Oil, and Related Flavoring Ingredients.”
• Gooderham, N.J., Cohen, S.M., Eisenbrand, G., Fukushima, S., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Rosol, T.J., Davidsen, J.M., Harman, C.L., Ramanan, D., and Taylor, S.V. (2023) Food Chem. Toxicol. 179, 113940. “FEMA GRAS Assessment of Natural Flavor Complexes: Sage Oil, Davana Oil, and other Related Flavoring Ingredients.”
• Rietjens, I.M.C.M., Cohen, S.M., Eisenbrand, G., Fukushima, S. Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rosol, T.J., Davidsen, J.M., Harman, C.L., and Taylor, S.V. (2023) Food Chem. Toxicol. 174, 113643. “FEMA GRAS Assessment of Natural Flavor Complexes: Allspice, Anise Fennel-derived and Related Flavoring Ingredients.”
• Davidsen, J.M., Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Rosol, T.J., Harman, C.L., Ramanan, D., and Taylor, S.V. (2023) Food Chem. Toxicol. 173, 113580. “FEMA GRAS Assessment of Natural Flavor Complexes: Asafetida Oil, Onion Oil, and Garlic Oil.”
• Davidsen, J.M., Rietjens, I.M.C.M., Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rosol, M., Harman, C.L., and Taylor, S.V. (2023) Food Chem. Toxicol. 175, 113646“FEMA GRAS Assessment of Basil, Nutmeg, Parsley, Tarragon and Related Allylalkoxybenzene Derivative-Containing Natural Flavor Complexes: Flavoring Ingredients.”
• Guengerich, F.P. (2023) J. Inorg. Biochem. 247, 112328. “Michael R. Waterman and Cytochrome P450.”
• Guengerich, F.P. (2023) Drug Metab. Dispos. 51, 99-104. “Drug Metabolism: A Half-Century Plus of Progress, Continuing Needs, and New Opportunities.”
• Cohen, S.M., Eisenbrand, G., Fukushima, S. Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Rosol, T.J., Harman, C., Davidsen, J.M., Rumanan, D., and Taylor, S.V. (2022) Food Toxicol. 76, 58-72. “GRAS 30 Flavoring Substances.”
• Guengerich, F.P. (2022) Arch. Biochem. Biophys. 109177. “The Discovery of a Role of Cytochrome b₅ in Cytochrome P450 Reactions.” (Commentary on Hildebrandt, A., and Estabrook, R.W. (1971) Arch. Biochem. Biophys. 143, 66-79.)
• Rendic, S., Crouch, R.D., and Guengerich, F.P. (2022) Arch. Toxicol. 96, 2145-2246. “Roles of Selected Non-P450 Human Oxidoreductase—Enzymes in Protective and Toxic Effects of Chemicals: Review and Compilation of Reactions.”
• Guengerich, F.P., Masters, B.S.S., and Morohashi, K. (2022) ASBMB Today 21, 8. “In Memorium: Tsuneo Omura.”
• Guengerich, F.P. (2022) ASBMB Today 21, 7. “In Memorium: Michael Waterman.”
• Guengerich, F.P. (2022) Biomolecules Therapeut. 30, 1-18. “Inhibition of Cytochrome P450 Enzymes by Drugs: Molecular Basis and Practical Applications.”