Recent Articles

• Zhu, Z., Chung, Y.-M., Alyamani, M., Dai, Y., McCarty, K.D., Roberts, E., Sinha, S., Li, J., Li, X., Gad, E.M., Zhou, C., Shi, J., Burgess, R.A., Hargrove, T.Y., Lepesheva, G.I., Guengerich, F.P., Auchus, R.J., and Sharifi, N. (2025) Nature Commun.16, 10611.“A Bypass Gateway from Cholesterol to Sex Steroid Biosynthesis.”
• Elizondo, A.I., McCarty, K.D., Guengerich, F.P., Arman, HJ.D., and Yoshimoto, F.K. (2025) Org. Biomolec. Chem. 23 (42) 9457-9724. “A Synthesis of 1b-Hydroxytestosterone, a Metabolite of Xenobiotic Human Cytochrome P450 Enzymes, Beginning with a Borylation of Boldione.” (selected for cover art)
• McCarty, K.D., Tateishi, Y., and Guengerich, F.P. (2025) J. Biol. Chem. 301, 110378. “Cytochrome P450_BM-3 and P450 11A1 Retain Compound I (FeO³⁺) Chemistry with Electrophilic Substrates Poised for Compound 0 (Fe³⁺O₂¯) Reactions.”
• McCarty, K.D., and Guengerich, F.P. (2025) J. Am. Soc. Mass Spectrom. 36, 1702-1717.  “Mass Spectral Analysis of Sterols and Other Steroids in Different Ionization Modes: Sensitivity and Oxidation Artifacts.”
• Hong, J.-K., Yeom, M., Hwang, H.-Y., Mun, E., Woo, J.-H., Kim, Y., Shin, J.-H. Lee, Y., Kim, D., Guengerich. F.P., and Choi, J.-Y. (2025) Chem.-Biol. Interact.416, 111551. “Four Germline POLH Variants, Including Two Found in Skin Tumors, Impair DNA Polymerase h Function and Cellular Tolerance to UV Radiation and Cisplatin.”
• McCarty, K.D., and Guengerich, F.P. (2025) J. Biol. Chem. 301, 108168. “Liver Fatty Acid Binding Protein FABP1 Transfers Substrates to Cytochrome P450 4A11 for Catalysis.”
• Koinuma, K., Noto, K., Morita, T., Uekusa, Y., Kikuchi, H., Shimoji,  M., Seki, H., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K., Imaoka, A., Akiyoshi, T., and Ohtani, H. (2025) J. Pharmaceut. Sci. 114, 849-856. “Kinetics of the Inhibition of CYP3A4 and CYP2C19 Activity by Jabara Juice and Identification of the Responsible Inhibitory Components.”
• Tomar, R., Ghodke, P.P., Patra, A., Smyth, E., Ponatarelli, A., Copp, W.  Guengerich, F.P., Chaput, J.J., Wilds, C.J., Stone, M.P., and Egli, M. (2024) Biochemistry 63, 2425-2439. “DNA Replication Across a-L-(3′-2′)-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.”
• Tateishi, Y., McCarty, K.D., Martin, M.V., Yoshimoto, F.K., and Guengerich, F.P. (2024) Angew. Chem., Int. Ed. 63, e202406542. “Roles of Ferric Peroxide Anion Intermediates (Fe3+O2¯) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Model.”
• Hargrove, T.Y., Lamb, D.C., Wawrazk, Z., Hull, M.T., Kelloy, S.L., La Scola, B., Guengerich, F.P., and Lepesheva, G.I. (2024) J. Med. Chem. 67, 7443-7457. “Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14a-Demethylase as a Key Drug Target.”
• Uehara, S., Murayama, N., Higuchi, Y., Shimizu, M., Suemizu, H. Guengerich, F.P., and Yamazaki, H. (2024) Chem. Res. Toxicol. 37, 671-674. “In Vivo and
  In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH Cells.”
• Tateishi, Y., McCarty, K.D., Martin, M.V., and Guengerich, F.P. (2024) ACS Catalysis. 14, 2388-2394. “Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4.”
• Tateishi, Y., Webb, S.N., Li, B., Liu, L., Lindsey Rose, K., Leser, M., Patel, P., and Guengerich, F.P. (2024) J. Biol. Chem. 300, 105688. “Proteomics, Modeling, and Fluorescence Assays Delineate Cytochrome b₅ Residues Involved in Binding and Stimulation of Cytochrome P450 17A1 Lyase.”
• McCarty, K.D., Tateishi, Y., Hargrove, T.Y., Lepesheva, G.I., and Guengerich, F.P. (2024) Angew. Chem., Int. Ed. 320231771 “Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in Cytochrome P450 51A1 Sterol 14a-Demethylation.”

Review Articles

• Guengerich, F. P. (2026, in press) in Recent Advances in Biotransformation of Drugs and Drug Candidates (Isin, E.M., and Walles, M., Eds.) Wiley, New York. “Historical Perspective on Drug Metabolism.”
• Norman, K.G., Kaufman, L.E., Greim, P., Loretz, L., Kowcz, A., Cohen, S.M., Scialli, A.R., Boobis, A.R., Jacobson-Kram, D., Schoeny, R., Rosol, T.J., Williams, G.M., Kaminski, N.E., Guengerich, F.P., and Nash, J.F. (2025) Crit. Rev. Toxicol. 55 (7), 716-734. “Comprehensive Review of Ensulizole Toxicology Data and Human Exposure Assessment for Personal Care Products.”
• Norman, K.G., Kaufman, L.E., D’Ruiz, C., Loretz, L., Kowcz, A., Cohen, S.M., Scialli, A.R., Boobis, A.R., Jacobson-Kram, D., Schoeny, R., Rosol, T.J., Williams, G.M., Kaminski, N.E., Guengerich, F.P., and Nash, J.F. (2025) Crit. Rev. Toxicol. 55 (6), 662-692. doi: 10:1080/10408444.2025.2535394. “Comprehensive Review of Avobenzone  Toxicology Data and Human Exposure Assessment for Personal Care Products.”
• Cohen, S.M., Rietjens, I.M.C.M., Levy, L., Berry, C., Boffetta, P., Boobis, A.R., Calabrese, E.J., Clewell, H., Cope, R., Cox, T., Dellarco, V., Dietrich, D., Dourson, M., Eaton, D.L., Fukushima, S., Gooderham, N.J., Goodman, J.I., Gori, G., Greim, H., Guengerich, F.P., Hagen, T., Hengstler, J.G., Jacobson-Kram, D., Klaassen, C., Klaunig, J.E., Lang, S., McClellan, R. O., Nebert, D..W., Paustenbach, D., Ramos, K., Rosol, T.J., and Wallace, K.B. (2025) Toxicol. Sci. 206, 1-3. “Chemical Risks and Children’s Health: Building on Progress Based on Science, Not Panic.”
• Cohen, S.M., Boobis, A.R., Jacobson-Kram, D., Schoeny, R., Rosol, T.J., Williams, G.M., Kaminski, N.E., Eichenbaum, G.M., Guengerich, F.P., and Nash, J.F. (2025) Crit. Rev. Toxicol. 55, 248-284. “Mode of Action Supports a Lack of Carcinogenic Potential of Six Organic UV Filters.” DOI:10.1080/10408444.2025.2462642.
• Guengerich, F.P. (2025, revised) Drug Metab. Rev. “Simplified Approaches to Kinetic Isotope Effects in Cytochrome P450-Catalyzed Reactions.”
• Guengerich, F.P. (2024) J. Biol. Chem. 300, 105625. “Reflection: Ninety-eight Semesters of Cytochrome P450 Enzymes and Related Topics—What Have I Taught and Learned?”
• Guengerich, F.P. (2024) Pharmacol. Rev. 76, 1104-1132. “Roles of Human Cytochrome P450 Enzymes in Drug Metabolism.”
• Rendic, S.P., and Guengerich, F.P. (2024) Arch. Toxicol. 98, 1581-1628. “Bioactivation of Drugs to Potentially Toxic Products Catalyzed by Human Drug-Metabolizing Enzymes.”
• Guengerich, F.P., Tateishi, Y., McCarty, K.D., and Yoshimoto, F.K. (2024) Int. J. Mol. Sci.25, 9020. “Recent Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations.”
• Guengerich, F.P. (2024) Drug Metab. Dispos. 52, 493-497. “Cytochrome P450 Enzymes as Drug Targets in Human Disease.”