Recent Articles

• Lee, S.-G., Kim, V., Lee, G.-H., Kim, C., Jeong, E., Guengerich, F.P., and Kim, D. (2023) J. Inorg. Biochem. 240, 112085 “Hydroxylation and Lyase Reactions of Steroids Catalyzed by Mouse Cytochrome P450 17A1 (Cyp17a1).”
• Chakraborty, S., Mallick, D., Goswami, M., Chakrabarty, A., Guengerich, F.P., and Chowdhury, G. (2022) J. Nat. Prod. 85, 2340-2350. “The Natural Products Withaferin A and Withanone from the Medicinal Herb Withania somnifera are Covalent Inhibitors of the SARS-Cov-2 Main Protease.” (Selected for Cover Art)
• Ghodke, P.P., Matse, J.H., Dawson, S., and Guengerich, F.P. (2022) Chem. Res. Toxicol. 35, 1805-1808. “Nucleophilic Thiol Proteins Bind Covalently to Abasic Sites in DNA.”
• Shimada, T., Nagayoshi, H., Murayama, N., Sawai, A., Kim, V., Kim, D., Yamazaki, H., Guengerich, F.P., and Takenaka, S. (2022) Xenobiotica 52, 134-145. “Oxidation of 3´-Methoxyflavone, 4´-Methoxyflavone, and 3´,4´-Demethoxyflavone and Their Derivatives Having 5,7-Dihydroxyl Groups by Human Cytochromes P450 1B1 and 2A13.”
• Hargrove, T., Wawrzak, Z., Rachakonda, G., Nes, W.D., Villalta, F., Guengerich, F.P., and Lepesheva, G.I. (2021) J. Med. Chem. 64, 17511-17522. “Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri are Accompanied by Resistance to Inhibition.”
• Glass, S.M., Webb, S.N., and Guengerich, F.P. (2021) Arch. Biochem. Biophys. 714, 109076. “Binding of Cytochrome P450 27C1, a Retinoid Desaturase, to its Accessory Protein Adrenodoxin.”
• Ghodke, P.P., and Guengerich, F.P. (2021) J. Biol. Chem. 297, 101124. “DNA Polymerases h and k Bypass N2-Guanine-O6-Alkylguanine DNA Alkyltransferase Crosslinked DNA-Peptides.”
• Glass, S. M., and Guengerich, F. P. (2021) J. Biol. Chem. 297, 101142. “Cellular Retinoid-Binding Proteins Transfer Retinoids to Human Cytochrome P450 27C1 for Desaturation.”
• Akiyoshi, T., Naitou, R., Imaoka, A., Miyazaki, M., Guengerich, F.P., Nakamura, K., Yamamoto, K., and Ohtani, H. (2021) Int. J. Clin. Pharmacol. Ther. 59, 745-752. “Time-dependent Inhibition of CYP3A4-mediated Midazolam Metabolism by Macrolide Antibiotics in CYP3A4 Genetic Variants: Comparison with Testosterone Metabolism”
• Guengerich, F.P., McCarty, K.D., Chapman, J.G., and Tateishi, Y. (2021) J. Biol. Chem. 297, 100969. “Stepwise Binding of Inhibitors to Human Cytochrome P450 17A1 and Relevance to Kinetics of Inhibition of Androgen Biosynthesis.” (Editors’ Pick)
• Kim, D., Kim, V., Tateishi, Y., and Guengerich, F.P. (2021) Drug Metab. Dispos. 49, 902-909. “Cytochrome b5 Binds Tightly to Several Human Cytochrome P450 Enzymes”
• Nagayoshi, H., Murayama, N., Takenaka, S., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F.P., and Shimada, T. (2021) Xenobiotica 51, 995-1009. “Roles of Cytochrome P450 2A6 in the Oxidation of Flavone by Human Liver Microsomes.”
• Ghodke, P.P., Mali, J.R., Patra, A., Rizzo, C.J., Guengerich, F.P., and Egli, M. (2021) J. Biol. Chem. 296, 100642. “Enzymatic Bypass and Structural Basis of Miscoding Opposite the DNA Adduct 1,N2-Ethenodeoxyguanosine By Human DNA Translesion Polymerase η.”
• Kim, D., Kim, V., McCarty, K.D., and Guengerich, F.P. (2021) J. Biol. Chem. 296, 100571. “Tight Binding of Cytochrome b5 to Cytochrome P450 17A1 is a Critical Feature of Stimulation of C21 Steroid Lyase Activity and Androgen Synthesis.”
• Ghodke, P.P., Gonzalez-Vasquez, G., Wang, H., Johnson, K.A., Sedgeman, C.A., and Guengerich, F.P. (2021) J. Biol. Chem. 296, 100449. “Enzymatic Bypass of an N6-Deoxyadenosine DNA-Ethylene Dibromide-Peptide Crosslink by Translesion DNA Polymerases.”
• Yamaguchi, Y., Akiyoshi, T., Kawamura, G., Imaoka, A., Miyazaki, M., Guengerich, F.P., Nakamura, K., Yamamoto, K., and Ohtani, H. (2021) Drug Metab. Pharmacokinetics 38, 100384. “Comparison of the Inhibitory Effects of Azole Antifungals on Cytochrome P450 3A4 Genetic Variants.”
• Guengerich, F.P., McCarty, K.D., and Chapman, J.G. (2020) J. Biol. Chem. 296, 100223. “Kinetics of Cytochrome P450 3A4 Inhibition by Heterocyclic Drugs Defines a General Sequential Multistep Binding Process.”
• Guengerich, F.P., Child, S.A., Barckhausen, I.F., and Goldfarb, M. H. (2021) ACS Catalysis 11, 639-649. “Kinetic Evidence for an Induced Fit Mechanism in the Binding of the Substrate Camphor by Cytochrome P450cam.”
• Shimada, T., Nagayoshi, H., Murayama, N., Takenaka, S., Katahira, J., Kim, V., Komori, M., Yamazaki, H., and Guengerich, F.P. (2021) Xenobiotica 51, 139-154. “Liquid Chromatography-Tandem Mass Spectrometry Analysis of Oxidation of 2´-,3´-,4´-, and 6-Hydroxyflavones by Human Cytochrome P450 Enzymes.”
• Glass, S.M., Reddish, M.J., Child, S.A., Wilkey, C.J., Stec, D.F., and Guengerich, F.P. (2020) J. Steroid Biochem. Mol. Biol. Nov 12:105787. “Characterization of Human Adrenal Cytochrome P450 11B2 Products of Progesterone and Androstenedione Oxidation.”
• Ahmed, N., Chakrabarty, A., Guengerich, F.P., and Chowdhury, G. (2020) Chem. Res. Toxicol. 33, 2668-2674. “Protective Role of Glutathione Against Peroxynitrite-mediated DNA Damage During Acute Inflammation.”
• Child, S.A., Reddish, M.J., Glass, S.M., Goldfarb, M.H., Barckhausen, I.R., and Guengerich, F.P. (2020) Arch. Biochem. Biophys. 694, 108596. “Functional Interactions of Adrenodoxin with Several Human Mitochondrial Cytochrome P450 Enzymes.”
• Hargove, T. Y., Wawrzak, Z., Guengerich, F.P., and Lepesheva, G.I. (2020) J. Biol. Chem. 295, 9998-10007. “A Requirement for an Active Proton Delivery Network Supports a Compound I C-C Bond Cleavage in CYP 51 Catalysis.”
• Yeom, J., Hong, J.-K., Kim, J.-K., Guengerich, F. P., and Choi, J.-Y. (2020) Chem. Res. Toxicol. 33, 2120-2129. “Three human pol ι variants with impaired polymerase activity fail to rescue H2O2 hypersensitivity in POLI-deficient cells.”
• Nagayoshi, H., Murayama, N., Tsujino, M., Takenaka, S., Katahira, J., Kim, D., Komori, M., Yamazaki, H., Guengerich, F.P., and Shimada, T. (2020) Xenobiotica 50, 1158-1169. “Preference for O-demethylation reactions in the oxidation of 2´-, 3´-, and 4´-methoxyflavones by human cytochrome P450 enzymes.”
• Guengerich, F.P., and Fekry, M.I. (2020) ACS Catalysis 10, 5008-5022. “Methylene Oxidation of Alkyl Sulfates by Cytochrome P450BM-3 and a Role for Conformational Selection in Substrate Recognition.”
• Child, S.A., and Guengerich, F.P. (2020) J. Med. Chem. 63, 6513-6522. “Multi-Step Binding of the Non-steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity.”
• Ghodke, P.P., and Guengerich, F.P. (2020) J. Biol. Chem. 295, 6092-6107. “Impact of 1,N6-Ethenoadenosine, a Damaged Ribonucleotide in DNA, on Translesion Synthesis and Repair.”

• Kloudova-Spalenkova, A., Ueng, Y-F., Wei, S., Kopeckova, K., Guengerich, F.P., and Soucek, P. (2020) J. Steroid Biochem. Mol. Biol. 197, 105566. “Plasma Oxysterol Levels in Luminal Subtype Breast Cancer Patients Are Associated with Clinical Data.”
• Mast, N., Verwilst, P. Wilkey, C.J., Guengerich, F.P., and Pikuleva, I.A. (2020) J. Med. Chem. “In Vitro Activation of CYP46A1 by Efavirenz-Related Compounds.” (selected for ACS Editors’ Choice)

Review Articles

• Guengerich, F.P. (2023) Drug Metab. Dispos. 51, 99-104. “Drug Metabolism: A Half-Century Plus of Progress, Continuing Needs, and New Opportunities.”
• Guengerich, F.P. (2022) Arch. Biochem. Biophys. 109177. “The Discovery of a Role of Cytochrome b₅ in Cytochrome P450 Reactions.” (Commentary on Hildebrandt, A., and Estabrook, R.W. (1971) Arch. Biochem. Biophys. 143, 66-79.)
• Rendic, S., Crouch, R.D., and Guengerich, F.P. (2022) Arch. Toxicol. 96, 2145-2246. “Roles of Selected Non-P450 Human Oxidoreductase—Enzymes in Protective and Toxic Effects of Chemicals: Review and Compilation of Reactions.”
• Guengerich, F.P., Masters, B.S.S., and Morohashi, K. (2022) ASBMB Today 21, 8. “In Memorium: Tsuneo Omura.”
• Guengerich, F.P. (2022) ASBMB Today 21, 7. “In Memorium: Michael Waterman.”
• Guengerich, F.P. (2022) Biomolecules Therapeut. 30, 1-18. “Inhibition of Cytochrome P450 Enzymes by Drugs: Molecular Basis and Practical Applications.”
• Rye, K.-A., Davidson, N.O., Burlingame, A.L., and Guengerich, F.P. (2021) J. Biol. Chem. 297, 101243 (also published in J. Lipid Res. and Mol. Cell. Proteomics). “Working Toward Reducing Bias in Peer Review.”
• Guengerich, F.P., and Ghodke, P.P. (2021, in press) Genes Environ. (special issue honoring Dr. T. Sugiyama) “Etheno Adducts in Nucleic Acids—From tRNA Modifications to DNA Adducts and Back to Miscoding RNA Adducts.”
• Guengerich, F.P., and Ghodke, P.P. (2021) Genes Environ. 43, 24 (special issue honoring Dr. T. Sugiyama). “Etheno Adducts from tRNA Modifications to DNA Adducts and Back to Miscoding Ribonucleotides.”
• Rendic, S., and Guengerich, F.P. (2021) Arch. Toxicol 95, 395-472. “Human Family 1-4 Cytochrome P450 Enzymes Involved in the Metabolic Activation of Xenobiotic and Physiological Chemicals: An Update.”
• Rendic, S. and Guengerich, F.P. (2020) Curr. Drug Metab. 14, 1127-1135. “Metabolism and Drug Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters.”
• Guengerich, F.P. (2020) Toxicol. Res. 37, 1-23. “A History of the Role of Cytochrome P450 Enzymes in the Toxicity of Drugs.”
• Li, Z., Jiang, Y., Guengerich, F.P., Ma, L., Li, S., and Zhang, W. (2020) J. Biol. Chem 295,.833-849. “Engineering Cytochrome P450 Systems for Practical Catalysis.”
• Guengerich, F.P., Meanwell, N., Georg, G.I., and Wang, S. (2020) J. Med. Chem. 63, 6249-6250. “Introduction: Drug Metabolism and Toxicology Special Issue.”
• Gooderham, N.J., Cohen, S.M., Eisenbrand G., Fukushima, S., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Davidsen, J.M., Harman, C., Murray, I. J., and Taylor, S.V. (2020) Food Chem. Toxicol. 145, 111585. “FEMA GRAS Assessment of Natural Flavor Complexes: Clove, Cinnamon Leaf, and West Indian Bay Leaf-derived Flavoring Ingredients.”
• Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Bastaki, M., Davidsen, J.M., Harman, C.L., McGowen, M.M., and Taylor, S.V. (2020) Food Chem. Toxicol. 135, 110870. “FEMA GRAS Assesment of Natural Flavor Complexes: Mint, Buchu, Dill, and Caraway Derived Flavoring Ingredients.”
• Rietjens, I.M.C.M., Cohen, S.M., Eisenbrand G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rosol, T.J., Davidsen, J.M., Harman, C.L., Murray, I.J., and Taylor, S.V. (2020) Food Chem. Toxicol. 135, 110949. “FEMA GRAS Assessment of Natural Flavor Complexes: Cinnamonum and Myroxylon-derived Flavoring Ingredients.”
• Li, Z., Jiang, Y., Guengerich, F.P., Ma, L., Li, S., and Zhang, W. (2020) J. Biol. Chem 295,.833-849. “Engineering Cytochrome P450 Systems for Practical Catalysis.”
• Gooderham, N.J., Cohen, S.M., Eisenbrand, G., Fukishima, S., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Rosol, R.J., Bastaki, M., Linman, M.J., and Taylor, S.V. (2020) Crit. Rev. Toxicol. 50, 1-27. “The Safety Evaluation of Food Flavoring Substances: The Role of Genotoxicity Studies.”