References and Articles

Recent Articles

  • Kloudova-Spalenkova, A., Ueng, Y-F., Wei, S., Kopeckova, K., Guengerich, F.P., and Soucek, P. (2020, in press) J. Steroid Biochem. Mol. Biol. “Plasma Oxysterol Levels in Luminal Subtype Breast Cancer Patients Are Associated with Clinical Data.”
  • Mast, N., Verwilst, P. Wilkey, C.J., Guengerich, F.P., and Pikuleva, I.A. (2019, in press) J. Med. Chem.In VitroActivation of CYP46A1 by Efavirenz-Related Compounds.” (selected for ACS Editors’ Choice)
  • Friggeri, L., Hargrove, T.Y., Wawrzak, Z., Guengerich, F.P., and Lepesheva, G.I. (2019) J. Med. Chem. 62, 10391-10401. “Validation of Human Cytochrome (CYP) 51A1 Druggability: Structure-guided Design, Synthesis, and Evaluation of Stoichiometric and Functionally Irreversible Inhibitors.”
  • Fekry, M., Xiao, Y., Berg, J.Z., and Guengerich, F.P. (2019) Drug Metab. Dispos. 47, 1325-1332. “A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty acid w-1 Hydroxylation Using an Untargeted Metabolomic Approach.”
  • Guengerich, F.P. (2019) Drug Metab. Dispos. 47, 1232-1239. “Kinetic Modeling of Steady-state Situations in Cytochrome P450 Enzyme Reactions.”
  • Reddish, M.J., and Guengerich, F.P. (2019) J. Biol. Chem. 294, 12975-12991. “Human Cytochrome P450 11B2 Produces Aldosterone by a Processive Mechanism Due to the Lactol Form of the Intermediate 18-Hydroxycorticosterone.”
  • Guengerich. F.P., Wilkey, C.J., and Phan, T.T.N. (2019) J. Biol. Chem. 294, 10928-10941. “Human Cytochrome P450 Enzymes Bind Drugs and Other Substrates Mainly Through Conformational Selection Modes.”
  • Chattopadhyay, M., Roy Chowdhury, A., Feng, T., Assenmacher, C.-A., Radaelli, E., Guengerich, F.P., and Avadhani, N.G. (2019) J. Biol. Chem. 294, 10336-10348. “Mitochondria-targeted Cytochrome P450 2D6 is Involved in Monomethylamine-induced Neuronal Damage in Mouse Models.”
  • Njuma, O.J., Su, Y., and Guengerich, F.P. (2019) J. Biol. Chem. 294, 10253-10265. “The Abundant DNA Adduct N7-Methyldeoxyguanosine Contributes to Miscoding During Replication by Human DNA Polymerase η.”
  • Guengerich, F.P., Wilkey, C.W., Glass, S.M., and Reddish, M.J. (2019) J. Biol. Chem. 294, 10028-10041. “Conformational Selection Dominates Binding of Steroids to Human Cytochrome P450 17A1.” (Selected as Editors Pick)
  • Nagayoshi, H., Murayama, N., Kakimoto, K., Tsujino, M., Takenaka, S., Katahira, J., Lim, Y.-R., Kim, D., Yamazaki, H., Komori, M., Guengerich, F.P., and Shimada, T. (2019) Chem. Res. Toxicol. 32, 1268-1280. “Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Respective Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes.”
  • Albertolle, M.E., Glass, S.M., Trefts, E., and Guengerich. F.P. (2019) J. Biol. Chem. 294, 6522-6530. “Isotopic Tagging of Oxidized and Reduced Cysteines (iTORC) for Detecting and Quantifying Sulfenic Acids, Disulfides, and Free Thiols in Cells.”
  • Su, Y., Ghodke, P.P., Egli, M., Li, L., Wang, Y., and Guengerich, F.P. (2019) J. Biol. Chem. 294, 6073-6081. “Human DNA Polymerase η Has Reverse Transcriptase Activity in Cellular Environments.”
  • Albertolle, M.E., Song, H., Wilkey, C.J., Segrest, J.P., and Guengerich, F.P. (2019) Chem. Res. Toxicol. 32, 484-492. “Role of Glutamine-451 in Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.”
  • Nagayoshi, H., Murayama, N., Kakimoto, K., Takenaka, S., Katahira, J., Lim, Y.-R., Kim, V., Kim, D., Yamazaki, H., Komori, M., Guengerich, F.P., and Shimada, T. (2019) Xenobiotica 49, 791-802. “Site-specific Oxidation of Flavanone and Flavone by Cytochrome P450 2A6 in Human Liver Microsomes.”
  • Kakimoto, K., Murayama, N., Takenaka, S., Nagayoshi, H., Lim, Y-R., Kim, V., Kim, D., Yamazaki, H., Komori, M., Guengerich, F.P., and Shimada, T. (2019) Xenobiotica 49,131-142. “Cytochrome 450 2A6 and Other Human P450 Enzymes in the Oxidation of Flavone and Flavanone.”
  • Friggeri, L., Hargrove, T., Rachakonda, G., Blobaum, A., Fisher, P., de Oliveira, G., Soeiro, M., Lindsley, C., Villalta, F., Guengerich, F.P., and Lepesheva, G. (2018) J. Med. Chem. 61, 10910-10921. “Sterols 14α-Demethylase Structure-based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.”
  • Hargrove, T.Y., Wawrzak, Z., Fisher, P.M., Child, S.A., Guengerich, F.P., Waterman, M.R., and Lepesheva, G.I. (2018) J. Biol. Chem. 293, 19344-19353. “Binding of a Physiological Substrate Causes Large Scale Conformational Reorganization in Cytochrome P450 51.”
  • Sausville, L.N., Gangadhariah, M.H., Chiusa, M., Mei, S., Wei, S., Zent, R., Luther, J.M., Shuey, M.M., Capdevila, J.H., Falck, J.R., Guengerich, F.P., Williams, S.M., and Pozzi, A. (2018) Cancer Res. 78, 4865-4877. “The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acids Production.”
  • Friggeri, L., Hargrove, T.Y. Wawrzak, Z., Blobaum, A.L., Lindsley, C., Villalta, F., Nes, W.D., Botta, M., Guengerich, F.P., and Lepesheva, G.I. (2018) J. Med. Chem. 61, 5679-5691. “Sterol 14α-Demethylase Structure-Based Design of VNI ((R)-N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives to Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.”
  • Murayama, N., Suemizu, H., Uehara, S., Kusama, T., Mitsui, M., Kamiya, Y., Shimizu, M., Guengerich, F.P., and Yamazaki, H. (2018) J. Toxicol. Sci. 43, 369-375. “Association of Pharmacokinetic Profiles of Lenalidomide in Human Plasma Simulated using Pharmacokinetic Data in Humanized-liver Mice with Liver Toxicity Detected by Human Serum Albumin RNA.”
  • Albertolle, M.E., Phan, T.T.N., Pozzi, A., and Guengerich, F.P. (2018) Mol. Cell. Proteomics 17, 889-900. “Sulfenylation of Human Liver and Kidney Cytochromes P450 and Other Drug Metabolizing Enzymes as a Response to Redox Alteration.”
  • Gonzalez, E., Johnson, K.M., Pallan, P.S., Phan, T.T.N., Zhang, W., Lei, L., Wawrzak, Z., Yoshimoto, F.K., Egli, M., and Guengerich, F.P. (2018) J. Biol. Chem. 293, 541-566. “Inherent Steroid 17α,20-Lyase Activity in Defunct Cytochrome P450 17A Enymes.”
  • Su, Y., Egli, M., and Guengerich, F.P. (2017) J. Biol. Chem. 292,18044-18051. “Human DNA Polymerase η Accomodates RNA for Strand Extension.”
  • Soucek, P., Vrana, D., Ueng, Y.-F., Wei, S., Kozevuikovona, R., and Guengerich, F.P. (2018) Clin. Chem. Lab. Med. 56, e78-e81. “Selective Changes in Cholesterol Metabolite Levels in Plasma of Breast Cancer Patients After Tumor Removal.”
  • Shimada, T., Murayama, N., Kakimoto, K., Takenaka, S., Lim, Y.-R., Yeom, S., Kim, D., Yamazaki, H., Guengerich, F.P., and Komori, M. (2018) Xenobiotica  48, 565-575. “Oxidation of 1-Chloropyrene by Human CYP1 Family and CYP2A Subfamily Cytochrome P450 Enzymes: Catalytic Roles of Two CYP1B1 and Five CYP2A13 Allelic Variants.”
  • Marsch, G.A., Carlson, B.T., Rogers, T.E., and Guengerich, F.P. (2018) J. Biomolec. Struct. Dynam. 36, 841-860.  “7,8-Benzoflavone Binding to Human Cytochrome P450 3A4 Reveals Complex Fluorescence Quenching, Suggesting Binding at Multiple Sites.”

Review Articles

  • Cohen, S.M., Rietjens, I.M.C.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Smith, R.L., Bastaki, M., Davidsen, J.M., Harman, C.L., McGowen, M.M., and Taylor, S.V. (2019, in press) Food Chem. Toxicol.“GRAS Affirmation of Mint, Buchu, Dill, and Caraway Natural Flavor Complexes Used as Flavoring Ingredients.”
  • Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Harman, C., and Taylor, S.V. (2019, in press) Food Technol. “Recent Progress in the Consideration of Flavoring Ingredients under the Food Additives Amendment. 29. GRAS Flavoring Substances.”
  • Gooderham, N.J., Cohen, S.M., Eisenbrand, G., Fukishima, S., Guengerich, F.P., Hecht, S.S., Rietjens, I.M.C.M., Rosol, R.J., Bastaki, M., Linman, M.J., and Taylor, S.V. (2019, in press) Crit. Rev. Toxicol. “The Safety Evaluation of Food Flavoring Substances: The Role of Genotoxicity Studies.
  • Guengerich, F.P. (2019) Chem. Res. Toxicol. 32, 944-945. “Judy L. Bolton, 1962-2019.”
  • Gierasch, L.M., and Guengerich, F.P. (2019) J. Biol. Chem. 294,1635-1637. “Celebrating the Scientific Legacy of Herbert Tabor.”
  • Ghodke, P.P., Albertolle, M.E., Johnson, K.M., and Guengerich, F.P. (2019) Curr. Prot. Nucleic Acid Chem. 76, e74. “Synthesis and Characterization of Site-Specific O6-Alkylguanine DNA-Alkyltransferase-Oligonucleotide Crosslinks.”
  • Guengerich, F.P. (2019) J. Biol. Chem. 294, 1671-1680. “Cytochrome P450 Research and The Journal of Biological Chemistry.”
  • Gierasch, L.M., and Guengerich, F.P. (2018) J. Biol. Chem. 293, 18803. “Happy Centennial Birthday to Herb Tabor, Pillar of JBC.”
  • Guengerich, F.P. (2018) ACS Catalysis 8, 10964-10976. “Perspective: Mechanisms of Cytochrome P450-catalyzed Oxidations.”
  • Guengerich, F.P. (2018) ASBMB Today 17,6-7. “Retrospective. Minor J. Coon (1921-2018).”
  • Guengerich, F.P. and Avadhani, N.G. (2018) Adv. Exp. Med. Biol. 1032, 15-25. “Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens.”
  • Rendic, S., and Guengerich, F.P. (2018) Drug Metab. Rev. 50,256-342. “Human Cytochrome P450 Enzyme 5-51 as Targets of Drugs, Natural, and Environmental Compounds: Mechanisms, Induction, and Inhibition—Toxic Effects and Benefits.”
  • Albertolle, M.E., and Guengerich, F.P. (2018) J. Inorg. Biochem. 186,228-234. “The Relationships Between Cytochromes P450 and H2O2: Production, Reaction, and Inhibition.”
  • Guengerich, F.P. (2018) J. Biol. Chem. 293, 8720-8721. “Biological Chemistry Without Borders.”
  • Smith, R.L., Cohen, S.M., Fukushima, S., Gooderham, N.J., Hecht, S.S., Guengerich, F.P., Rietgens, I.M.C.M., Bastaki, M., Harman, C.L., McGowen, M.M., Valerio, L.G., Jr., and Taylor, S.V. (2018) Toxicol. Res. 7,618-646. “The Safety Evaluation of Food Flavoring Substances: The Role of Metabolic Studies.”
  • Cohen, S.M., Eisenbrand, G., Fukushima, S., Gooderham, N.J., Guengerich, F.P., Hecht, S.S., Rietgens, I.M.C.M., Davidsen, J.M., Harman, C.L., and Taylor, S.V. (2018) Food Chem. Toxicol. 113,171-178. “Updated Procedure for the Safety Evaluation of Natural Flavor Complexes Used as Ingredients in Food.”
  • Guengerich, F.P., and Yoshimoto, F.K. (2018) Chem. Rev. 118,6573-6655. “Formation and Cleavage of C-C Bonds by Enzymatic Oxidation Reactions.”
  • Guengerich, F.P. (2018) J. Biol. Chem. 293,4653-4663. “Introduction to Metals in Biology 2018. Copper Homeostasis and Utilization in Redox Enzymes.”
  • Rendic, S., and Guengerich, F.P. (2018) Curr. Drug Metab. 19,3-46. “Development and Uses of Offline and WEB-Searchable Databases. The Case of Benzo[a]pyrene.”

Back Home   

Links

July 2020
S M T W T F S
     
 1234
567891011
12131415161718
19202122232425
262728293031