Irish Lab

A central goal of our research at Vanderbilt is to understand how changes at the single cell level alter signaling in healthy cells and lead to therapy resistant populations in human diseases.  In the Irish Lab, we use new tools and computational approaches to do basic and translational research in human cancer and immunology.

Incoming graduate students: Yes, we are open for rotations!

In addition to making discoveries at the frontier of human genetics and immunology, we aspire to use knowledge of cell signaling to create therapeutic technologies and to guide clinical decisions.  In the long term, great potential exists to detect disease earlier and to tailor a patient’s therapy to the biological alterations detected in the cells of their disease.  By better understanding biological systems which control development and cell-cell interactions in healthy and diseased contexts, we can learn to program cells to become therapeutic agents or target malignant signaling events to specifically kill cancer cells.

Jonathan Irish & The Irish Lab

Publications: Google Scholar | Pubmed
(Also see news feed on the right of this page for publication highlights.)

Mass cytometry: Looking for mass cytometry support?  The Irish lab operates two cores than can help.  New users should check out the fee-for-service Cancer & Immunology Core (CIC).  Advanced users at Vanderbilt may wish to join the Mass Cytometry Center of Excellence (MCCE).

Affiliations: The Irish lab’s primary affiliation is the Department of Cell & Developmental Biology (CDB) at Vanderbilt University, School of Medicine.  Dr. Irish holds a secondary appointment in the Department of Pathology, Microbiology & Immunology (PMI) at Vanderbilt University Medical Center.  Graduate students from IGP/CPB can select from diverse Programs matching their interests and training needs.

The Irish lab is also part of the Vanderbilt-Ingram Cancer Center (VICC), the Center for Quantitative Sciences (CQS), the Vanderbilt University Institute for Imaging Sciences (VUIIS), the Vanderbilt Center for Immunobiology (VCI),  the  Vanderbilt Institute of Infection, Immunology and Inflammation (VI4), and the Vanderbilt Institute of Chemical Biology (VICB).