Irish Lab Approach: Single cell systems biology for personalized medicine

Single cell systems biology for personalized medicine

Irish Lab
Vanderbilt University




A central goal of our research at Vanderbilt is to understand how changes at the single cell level alter signaling in healthy cells and lead to therapy resistant populations in human diseases.

In the Irish Lab, we use new tools and computational approaches to do basic and translational research in human cancer and immunology.

In addition to making discoveries at the frontier of human genetics and immunology, we aspire to use knowledge of cell signaling to create therapeutic technologies and to guide clinical decisions.  In the long term, great potential exists to detect disease earlier and to tailor a patient’s therapy to the biological alterations detected in the cells of their disease.  By better understanding biological systems which control development and cell-cell interactions in healthy and diseased contexts, we can learn to program cells to become therapeutic agents or target malignant signaling events to specifically kill cancer cells.

-Jonathan Irish & The Irish Lab

Featured publications:
- Characterizing phenotypes and signaling networks of single human cells by mass cytometry. Leelatian N, Diggins KE, Irish JM, Methods Mol Bio. 2015.

- Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B cells. Polikowsky HG, Wogsland CE, Diggins KE, Huse K, Irish JM, J Immunol. 2015.

Methods for discovery and characterization of cell subsets in high dimensional mass cytometry data. Diggins KE, Ferrell PB, Irish JM, Methods. 2015.

Beyond the age of cellular discovery. Irish JM, Nat Immunol. 2014.

High-dimensional single-cell cancer biology. Irish JM and Doxie DB, Curr Top Microbiol Immunol. 2014.