Personalized Structural Biology

Publications

deletion hypothesis

Proposing a structural mechanism for a deletion mutant

  1. Konduri K, Gallant JN, Chae YK, Giles FJ, Gitlitz BJ, Gowen K, Ichihara E,Owonikoko TK, Peddareddigari V, Ramalingam SS, Reddy SK, Eaby-Sandy B, Vavalà T, Whiteley A, Chen H, Yan Y, Sheehan JH, Meiler J, Morosini D, Ross JS, StephensPJ, Miller VA, Ali SM, Lovly CM. EGFR Fusions as Novel Therapeutic Targets in Lung Cancer. Cancer Discov. 2016 Jun;6(6):601-11. doi:10.1158/2159-8290.CD-16-0075. Epub 2016 Apr 21. PubMed PMID: 27102076; PubMedCentral PMCID: PMC4893907.
  2. Gallant JN, Sheehan JH, Shaver TM, Bailey M, Lipson D, Chandramohan R, RedBrewer M, York SJ, Kris MG, Pietenpol JA, Ladanyi M, Miller VA, Ali SM, Meiler J,Lovly CM. EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driverin Lung Cancer That Is Clinically Responsive to Afatinib. Cancer Discov. 2015Nov;5(11):1155-63. doi: 10.1158/2159-8290.CD-15-0654. Epub 2015 Aug 18. PubMedPMID: 26286086; PubMed Central PMCID: PMC4631701.