Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic disease of the esophagus that involves fibroblast activation and progression to fibrostenosis. Cytokines produced by T-helper 2 (Th2) cells and transforming growth factor beta 1 (TGFB1) contribute to development of EoE, but other cytokines involved in pathogenesis are unknown. We investigate the effects of TNF superfamily member 14 (TNFSF14, also called LIGHT) on fibroblasts in EoE.