Monthly Archives: July 2020

On March 27, Nashville resident Bill Boyce, 73, earned the unwelcome distinction of becoming the first patient intubated on Vanderbilt University Medical Center’s dedicated COVID-19 unit. He spent 28 days under the vigilant care of the inpatient COVID-… Continue reading →

The news about remdesivir, the investigational anti-viral drug that has shown early promise in the fight against COVID-19, keeps getting better. Continue reading →

A snapshot of some of the numbers that help tell the story of COVID-19 at Vanderbilt. Continue reading →

Five months into the COVID-19 pandemic, Vanderbilt University Medical Center continues to receive numerous generous donations, large and small, from individuals, corporations, non-profits and other benefactors. Continue reading →

As part of their video series on dealing with the pandemic, Dr. William Schaffner and Dr. Tom Talbot discuss practical risk assessment of everyday activities in reducing the risk of spreading COVID-19. Continue reading →

Among 249 front-line health care workers who cared for COVID-19 patients during the first month of the pandemic in Tennessee, 8% tested positive for COVID-19 antibodies by serology testing, suggesting they had contracted COVID-19 in the first several w… Continue reading →

Excess and unresolved endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6) is one of the signaling mediators of ER stress. We studied the pathways that regula… Continue reading →

Alterations in the gut microbiome have been associated with the severity of nonalcoholic fatty liver disease (NAFLD). These studies focused exclusively on the bacteria in the microbiome; we investigated changes in the viral microbiome (virome) in patie… Continue reading →

The mechanisms by which macrophages regulate intestinal epithelial cell (IEC) barrier properties are poorly understood. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) protects the IEC barrier from inflammation-induced disruption and regulates… Continue reading →