Publications

Work from our Group

Selective demethylation of O-aryl glycosides by iridium-catalyzed hydrosilylation
Jones, C. A. H.; Schley, N. D.
Chem. Commun., 2021, 57, 5953–5956.
DOI: 10.1039/D1CC00496D
carb_dem

Reversible C(sp3)-Si Oxidative Addition of Unsupported Organosilanes: Effects of Silicon Substituents on Kinetics and Thermodynamics
Chapp, S. M.; Schley, N. D.
J. Am. Chem. Soc., 2021, 143, 5534–5539.
DOI: 10.1021/jacs.1c01564
silyl

Ligand-Driven Advances in Iridium-Catalyzed sp3 C–H Borylation: 2,2′-Dipyridylarylmethane
Jones, M. R.; Schley, N. D.
Synlett, 2021, 32, 845-850.
DOI: 10.1055/a-1344-1904
synpac

Product Inhibition in Nucleophilic Aromatic Substitution through DPPPent-Supported π-Arene Catalysis
Mueller, B. R. J.; Schley, N. D.
Dalton Transactions, 2020, 49, 10114–10119.
DOI: 10.1039/D0DT00786B
arene

Selectivity and Mechanism of Iridium-Catalyzed Cyclohexyl Methyl Ether Cleavage
Fast, C. D.; Jones, C. A. H.; Schley, N. D.
ACS Catalysis, 2020, 10, 11, 6450–6456.
DOI: 10.1021/acscatal.0c01718
Featured at Organic-chemistry.org: Highlights: Reduction
demeth

Group-Transfer Reactions of a Cationic Iridium Alkoxycarbene Generated by Ether Dehydrogenation
Chapp, S. M.; Schley, N. D.
Inorg. Chem., 2020, 59, 10, 7143–7149.
DOI: 10.1021/acs.inorgchem.0c00609
grptransf

Iridium-Catalyzed sp3 C–H Borylation in Hydrocarbon Solvent Enabled by 2,2′-Dipyridylarylmethane Ligands
Jones, M. R.; Fast, C. D.; Schley, N. D.
J. Am. Chem. Soc., 2020, 142, 14, 6488-6492.
DOI: 10.1021/jacs.0c00524
Featured at Organic-chemistry.org: Highlights: C-H functionalization
jonesboryl

Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes
Jones, C. A. H.; Schley, N. D.
Org. Biomol. Chem., 2019. 17, 1744-1748.
DOI: 10.1039/C8OB02298D
Invited submission – New Talent, 2019.
debenzy

Formation of a Delocalized Iridium Benzylidene with Azaquinone Methide Character via Alkoxycarbene Cleavage
Zhang, Y.; Mueller, B. R. J.; Schley, N. D.
Organometallics, 2018, 37 (12), pp 1825–1828.
DOI: 10.1021/acs.organomet.8b00249
azaqu

Evidence for reversible cyclometalation in alkane dehydrogenation and C-O bond cleavage at iridium bis(phosphine) complexes
Chapp, S. M.; Schley, N. D.
Organometallics, 2017, 36 (22), pp 4355–4358.
DOI: 10.1021/acs.organomet.7b00676
irallyl

Reversible alkoxycarbene formation by C–H activation of ethers via discrete, isolable intermediates
Zhang, Y.; Schley, N. D.
Chem. Commun., 2017, 53, 2130–2133.
DOI: 10.1039/C6CC09838J
dicarbene


Book Chapters and Perspectives

Pioneers and Influencers in Organometallic Chemistry: Professor Robert Crabtree’s Storied Career via an Unusual Journey to the Ivy League
Dobereiner, G. E.; Hazari, N.; Schley, N. D.
Organometallics 2021, 40, 295–301.
DOI: 10.1021/acs.organomet.0c00797


Collaborative Work

Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids
Huseman, E. D.; Byl, J. A. W.; Chapp, S. M.; Schley, N. D.; Osheroff, N.; Townsend, S. D.
ACS Central Science 2021, 7, 1327-1337.
DOI: 10.1021/acscentsci.1c00040

Electronic structure analysis and reactivity of the bimetallic bis-titanocene vinylcarboxylate complex, [(Cp2Ti)2(O2C3TMS2)].
Huh, D. N.; Maity, A.; Van Trieste, G. P.; Schley, N. D.; Powers, D. C.; Tonks, I. A.
Polyhedron 2021, 207, 115368.
DOI: 10.1016/j.poly.2021.115368

Di(indenyl)beryllium
Koby, R. F.; Schley, N. D.; Hanusa, T. P.
Angew. Chem. Int. Ed. 2021, 60, 21174-21178.
DOI: 10.1002/anie.202107980

Mechanochemical Formation, Solution Rearrangements, and Catalytic Behavior of a Polymorphic Ca/K Allyl Complex
Koby, R. F.; Doerr, A. M.; Rightmire, N. R.; Schley, N. D.; Brennessel, W. W.; Long, B. K.; Hanusa, T. P.
Chem. Eur. J. 2021, 27,8195-8202.
DOI: 10.1002/chem.202100589

How important are the intermolecular hydrogen bonding interactions in methanol solvent for interpreting the chiroptical properties?
Polavarapu, P. L.; Santoro, E.; Covington, C. L.; Johnson, J. L.; Puente, A. R.; Schley, N. D.; Kallingathodi, Z.; Prakasan, P. C.; Haleema, S.; Thomas, A. A.; Ibnusaud, I.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2021, 247, 119094
DOI: 10.1016/j.saa.2020.119094

High circularly polarized luminescence brightness from analogues of Shibasaki’s lanthanide complexes.
Deng, M.; Schley, N. D.; Ung, G.
Chem. Commun. 2020, 56, 14813-14816
DOI: 10.1039/D0CC06568D

Alkali-metal- and halide-free dinuclear mixed-valent samarium and europium complexes.
Mukthar, N. F. M.; Schley, N. D.; Ung, G.
Dalton Transactions 2020, 49, 16059-16061
DOI: 10.1039/D0DT01095B

Systematic evaluation of the electronic effect of aluminum-containing ligands in iridium–aluminum and rhodium–aluminum bimetallic complexes
Charles, R. M.; Taylor, N. S.; Mercado, A. A.; Frost, C. E.; Yokley, T. W.; Eckenhoff, W. T.; Schley, N. D.; DeYonker, N. J.; Brewster, T. P.
Dalton Transactions 2020, 49, 13029-13043
DOI: 10.1039/D0DT02472D

CO2 Capture by 2-(Methylamino)pyridine Ligated Aluminum Alkyl Complexes.
Yokley, T. W.; Tupkar, H.; Schley, N. D.; DeYonker, N. J.; Brewster, T. P.
Eur. J. Inorg. Chem. 2020, 2020, 2958-2967.
DOI: 10.1002/ejic.202000437

Study and modular synthesis of unsymmetrical bis(phosphino)pyrrole ligands.
Fokwa, H. D.; Vidlak, J. F.; Weinberg, S. C.; Duplessis, I. D.; Schley, N. D.; Johnson, M. W.
Dalton Transactions 2020, 49, 9957-9960.
DOI: 10.1039/D0DT02063J

Circularly Polarized Luminescence from Enantiopure C2-Symmetrical Tetrakis(2-pyridylmethyl)-1,2-diaminocyclohexane Lanthanide Complexes.
Ayers, K. M.; Schley, N. D.; Ung, G.
Inorg. Chem. 2020, 59, 11, 7657–7665.
DOI: 10.1021/acs.inorgchem.0c00628

Synthesis of Enantiopure Lanthanide Complexes Supported by Hexadentate N,N′-Bis(methylbipyridyl)bipyrrolidine and Their Circularly Polarized Luminescence.
Schnable, D.; Freedman, K.; Ayers, K. M.; Schley, N. D.; Kol, M.; Ung, G.
Inorg. Chem. 2020, 59, 8498-8504.
DOI: 10.1021/acs.inorgchem.0c00946

Algal Toxin Goniodomin A Binds Potassium Ion Selectively Yielding a Conformationally Altered Complex Having Biological Consequences.
Tainter, C. J.; Schley, N. D.; Harris, C. M.; Stec, D. F.; Song, A. K.; Balinski, A.; May, J. C.; McLean, J. A.; Reece, K. S.; Harris, T. M.,
Journal of Natural Products, 2020, 83, 4, 1069–1081.
DOI: 10.1021/acs.jnatprod.9b01094

Synthesis and Electronic Characterization of Iridium-Aluminum and Rhodium-Aluminum Heterobimetallic Complexes Bridged by 3-Oxypyridine and 4-Oxypyridine.
Charles III, R. M.; Tupkar, H.; Helland, S. D.; Mercado, A. A.; Eckenhoff, W. T.; Schley, N. D.; DeYonker, N. J.; Brewster, T. P.
Eur. J. Inorg. Chem. 2020, 2020, 1192-1198.
DOI: 10.1002/ejic.201901317

An η3-Bound Allyl Ligand on Magnesium in a Mechanochemically Generated Mg/K Allyl Complex.
Koby, R. F.; Doerr, A. M.; Rightmire, N. R.; Schley, N. D.; Long, B. K.; Hanusa, T. P.
Angew. Chem. Int. Ed. 2020, 59, 9542-9548.
DOI: 10.1002/anie.201916410

Rhodium and iridium NNO-Scorpionate complexes: synthesis, structure, and reactivity with aluminum alkyls.
Yokley, T. W.; Schley, N. D.; Brewster, T. P.
Inorg. Chim. Acta 2020, 506, 119529.
DOI: 10.1016/j.ica.2020.119529

Yellow Circularly Polarized Luminescence from C1‐Symmetrical Copper(I) Complexes
Deng, M.; Mukthar, N. F. M.; Schley, N. D.; Ung, G.
Angew. Chem. Int. Ed., 2020, 59,1228–1231.
DOI: 10.1002/anie.201913672

Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism
Yousefi, R.; Struble, T. J.; Payne, J. L.; Vishe, M.; Schley, N. D.; Johnston, J. N.
J. Am. Chem. Soc., 2019, 141 (1), 618-625.
DOI: 10.1021/jacs.8b11793

Halide metathesis in overdrive: mechanochemical synthesis of a heterometallic group 1 allyl complex
Koby, R. F.; Rightmire, N. R.; Schley, N. D.; Hanusa, T. P.; Brennessel, W. W.
Beilstein Journal of Organic Chemistry 2019, 15, 1856-1863.
DOI: 10.3762/bjoc.15.181

Monometallic lanthanide salicylhydrazone complexes exhibiting strong near-infrared luminescence
Ayers, K. M.; Schley, N. D.; Ung, G.
Chem. Commun., 2019, 55, 8446–8449.
DOI: 10.1039/C9CC03934A

Hydrogen Activation and Hydrogenolysis Facilitated By Late-Transition-Metal–Aluminum Heterobimetallic Complexes.
Charles, R. M.; Yokley, T. W.; Schley, N. D.; DeYonker, N. J.; Brewster, T. P.
Inorganic Chemistry, 2019, 58, 12635-12645.
DOI: 10.1021/acs.inorgchem.9b01359

Synthesis and characterization of rhodium–aluminum heterobimetallic complexes tethered by a 1,3-bis(diphenylphosphino)-2-propanoxy group.
Li, Z.; Yokley, T. W.; Tran, S. L.; Zong, J.; Schley, N. D.; Brewster, T. P.
Dalton Transactions, 2019, 48, 8782-8790.
DOI: 10.1039/C9DT00938H

Solid State Structures, Solution Behavior, and Luminescence of Simple Tetrakis(2-pyridylmethyl)ethylenediamine Lanthanide Complexes.
Ayers, K. M.; Schley, N. D.; Ung, G.
European Journal of Inorganic Chemistry, 2019, 2019, 3769-3775.
DOI: 10.1002/ejic.201900609

Absolute Configurations of Naturally Occurring [5]-and [3]-Ladderanoic Acids: Isolation, Chiroptical Spectroscopy and Crystallography
Raghavan, V.; Johnson, J. L.; Stec, D. F.; Song, B.; Zajac, G.; Baranska, M.; Harris, C. M.; Schley, N. D.; Polavarapu, P. L.; Harris, T. M.
Journal of Natural Products, 2018, 81 (12), 2654–2666.
DOI: 10.1021/acs.jnatprod.8b00458.

Solvent Dependent Sensitization of Ytterbium and Neodymium via an Intramolecular Excimer
Deng, M.; Schley, N. D.; Ung, G.
Inorg. Chem. 2018, 57 (24), pp 15399–15405.
DOI: 10.1021/acs.inorgchem.8b02709

Mechanochemically driven transformations in organotin chemistry: stereochemical rearrangement, redox behavior, and dispersion-stabilized complexes
Koby, F. R.; Hanusa, T. P.*; Schley, N. D.
J. Am. Chem. Soc., 2018, 140 (46), pp 15934–15942.
DOI: 10.1021/jacs.8b09862

Synthesis, Structure, and Reactivity of Palladium Proazaphosphatrane Complexes Invoked in C–N Cross-Coupling.
Matthews, A. D.; Gravalis, G. M.; Schley, N. D.; Johnson, M. W.
Organometallics 2018, 37 (18), pp 3073–3078.
DOI: 10.1021/acs.organomet.8b00453

Synthesis and Characterization of Heterobimetallic Iridium–Aluminum and Rhodium–Aluminum Complexes
Brewster, T. P.; Nguyen, T. H.; Li, Z.; Eckenhoff, W. T.; Schley, N. D.; DeYonker, N. J.
Inorg. Chem. 2018, 57 (3), pp 1148–1157.
DOI: 10.1021/acs.inorgchem.7b02601


Prior to Vanderbilt

Nickel-Catalyzed Negishi Arylations of Propargylic Bromides: A Mechanistic Investigation.
Schley, N. D.; Fu, Gregory C.
J. Am. Chem. Soc., 2014, 136 (47), 16588–16593.
DOI: 10.1021/ja508718m

Hydrogen-Transfer Catalysis with Cp*Ir-III Complexes: The Influence of the Ancillary Ligands.
Hintermair, U.; Campos, J.; Brewster, T. P.; Pratt, L. M.; Schley, N. D.; Crabtree, R. H.
ACS Catalysis 2014, 4, 99–108.
DOI: 10.1021/cs400834q

Domain Structure for an Amorphous Iridium-Oxide Water-Oxidation Catalyst Characterized by X-Ray Pair Distribution Function Analysis.
Huang, J.; Blakemore, J. D.; Fazi, D.; Kokhan, O.; Schley, N. D.; Crabtree, R. H.; Brudvig, G. W.; Tiede, D. M.
Phys. Chem. Chem. Phys. 2014, 16, 1814–1819.
DOI: 10.1039/C3CP54878C

Characterization of an Amorphous Iridium Water-Oxidation Catalyst Electrodeposited from Organometallic Precursors.
Blakemore, J. D.; Mara, M. W.; Kushner-Lenhoff, M. N.; Schley, N. D.; Konezny, S. J.; Rivalta, I.; Negre, C. F. A.; Snoeberger, R. C.; Kokhan, O.; Huang, J.; Stickrath, A.; Tran, L. A.; Parr, M. L.; Chen, L. X.; Tiede, D. M.; Batista, V. S.; Crabtree, R. H.; Brudvig, G. W.
Inorg. Chem. 2013, 52, 1860–1871.
DOI: 10.1021/ic301968j

Effects of Aqueous Buffers on Electrocatalytic Water Oxidation with an Iridium Oxide Material Electrodeposited in Thin Layers from an Organometallic Precursor.
Kushner-Lenhoff, M. N.; Blakemore, J. D.; Schley, N. D.; Crabtree, R. H.; Brudvig, G. W.
Dalton Trans. 2013, 42, 3617–3622.
DOI: 10.1039/C2DT32326E

Symmetrical Hydrogen Bonds in Iridium(III) Alkoxides with Relevance to Outer Sphere Hydrogen Transfer.
Schley, N. D.; Halbert, S.; Raynaud, C.; Eisenstein, O.; Crabtree, R. H.
Inorg. Chem. 2012, 51 (22), 12313–13323.
DOI: 10.1021/ic301601c

Mild, Reversible Reaction of Iridium(III) Amido Complexes with Carbon Dioxide.
Dobereiner, G. E.; Wu, J.; Manas, M. G.; Schley, N. D.; Takase, M. K.; Crabtree, R. H.; Hazari, N.; Maseras, F.; Nova, A.
Inorg. Chem. 2012, 51 (18), 9683–9693.
DOI: 10.1021/ic300923c

A Comparison of Amorphous Iridium Water-Oxidation Electrocatalysts Prepared from Soluble Precursors.
Blakemore, J. D.; Schley, N. D.; Kushner-Lenhoff, M. N.; Winter, A. M.; D’Souza, F.; Crabtree, R. H.; Brudvig, G. W.
Inorg. Chem. 2012, 51 (14), 7749–7763.
DOI: 10.1021/ic300764f

Ultrafast Photodriven Intramolecular Electron Transfer from an Iridium-Based Water-Oxidation Catalyst to Perylene Diimide Derivatives.
Vagnini, M. T.; Smeigh, A. L.; Blakemore, J. D.; Eaton, S. W.; Schley, N. D.; D’Souza, F.; Crabtree, R. H.; Brudvig, G. W.; Co, D. T.; Wasielewski, M. R.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109 (39), 15651–15656.
DOI: 10.1073/pnas.1202075109

Characterization of an Activated Iridium Water Splitting Catalyst Using Infrared Photodissociation of H2 Tagged Ions.
Garand, E.; Fournier, J. A.; Kamrath, M. Z.; Schley, N. D.; Crabtree, R. H.; Johnson, M. A.
Phys. Chem. Chem. Phys. 2012, 14, 10109–10113.
DOI: 10.1039/C2CP41490B

Electron-Rich CpIr(biphenyl-2,2′-diyl) Complexes with π-Accepting Carbon Donor Ligands.
Graeupner, J.; Brewster, T. P.; Blakemore, J. D.; Schley, N. D.; Thomsen, J. M.; Brudvig, G. W.; Hazari, N.; Crabtree, R. H.
Organometallics 2012, 31, 7158–7164.
DOI: 10.1021/om300696t

Axially Chiral Dimeric Ir and Rh Complexes Bridged by Flexible NHC Ligands.
Ashley, J. M.; Farnaby, J. H.; Hazari, N.*; Kim, K. E.; Luzik Jr, E. D.; Meehan, R, E.; Meyer, E. B.; Schley, N. D.; Schmeier T. J.; Tailor, A. N.
Inorg. Chim. Acta. 2012, 380, 399–410.
DOI: 10.1016/j.ica.2011.11.034

Oxidative Synthesis of Amides and Pyrroles via Dehydrogenative Alcohol Oxidation by Ruthenium Diphosphine Diamine Complexes.
Schley, N. D.; Dobereiner, G. E.; Crabtree, R. H.
Organometallics 2011, 30 (15), 4174–4179.
DOI: 10.1021/om2004755

Distinguishing Homogeneous from Heterogeneous Catalysis in Electrode-Driven Water Oxidation with Molecular Iridium Complexes.
Schley, N. D.; Blakemore, J. D.; Subbaiyan, N. K.; Incarvito, C. D.; D’Souza, F.; Crabtree, R. H.; Brudvig, G. W.
J. Am. Chem. Soc. 2011, 133 (27), 10473–10481.
DOI: 10.1021/ja2004522
Highlighted: Meyer, T. J., Nat. Chem. 2011, 3, 757–758. DOI: 10.1038/nchem.1161

Thiocyanate Linkage Isomerism in a Ruthenium Polypyridyl Complex.
Brewster, T. P.; Ding, W.; Schley, N. D.; Hazari, N.; Batista, V. S.; Crabtree, R. H.
Inorg. Chem. 2011, 50, 11938−11946.
DOI: 10.1021/ic200950e

Iridium-Catalyzed Hydrogenation of N-Heterocyclic Compounds under Mild Conditions by an Outer Sphere Pathway.
Dobereiner, G. E.; Nova, A.; Schley, N. D.; Hazari, N.; Miller, S. J.; Eisenstein, O.; Crabtree, R. H.
J. Am. Chem. Soc. 2011, 133 (19), 7547–7562.
DOI: 10.1021/ja2014983

An Iridium(IV) Species, [Cp*Ir(NHC)Cl]+, Related to a Water-Oxidation Catalyst.
Brewster, T. P.; Blakemore, J. D.; Schley, N. D.; Incarvito, C. D.; Hazari, N.; Brudvig, G. W.; Crabtree, R. H.
Organometallics 2011, 30 (5), 965–973.
DOI: 10.1021/om101016s

An Experimental-Theoretical Study of the Factors That Affect the Switch between Ruthenium-Catalyzed Dehydrogenative Amide Formation versus Amine Alkylation.
Nova, A.; Balcells, D.; Schley, N. D.; Dobereiner, G. E.; Crabtree, R. H.; Eisenstein, O.
Organometallics 2010, 29 (23), 6548–6558.
DOI: 10.1021/om101015u

Anodic Deposition of a Robust Iridium-Based Water-Oxidation Catalyst from Organometallic Precursors.
Blakemore, J. D.; Schley, N. D.; Olack, G. W.; Incarvito, C. D.; Brudvig, G. W.; Crabtree, R. H.
Chem. Sci. 2011, 2 (1), 94–98.
DOI: 10.1039/C0SC00418A

Half-Sandwich Iridium Complexes for Homogeneous Water-Oxidation Catalysis.
Blakemore, J. D.; Schley, N. D.; Balcells, D.; Hull, J. F.; Olack, G. W.; Incarvito, C. D.; Eisenstein, O.; Brudvig, G. W.; Crabtree, R. H.
J. Am. Chem. Soc. 2010, 132 (45), 16017–16029.
DOI: 10.1021/ja104775j

Cp* Iridium Complexes Give Catalytic Alkane Hydroxylation with Retention of Stereochemistry.
Zhou, M.; Schley, N. D.; Crabtree, R. H.
J. Am. Chem. Soc. 2010, 132 (36), 12550–12551.
DOI: 10.1021/ja1058247

Acyl Protection Strategy for Synthesis of a Protic NHC Complex via N-Acyl Methanolysis.
Dobereiner, G. E.; Chamberlin, C. A.; Schley, N. D.; Crabtree, R. H.
Organometallics 2010, 29 (21), 5728–5731.
DOI: 10.1021/om100452g

Iridium and Ruthenium Complexes with Chelating N-Heterocyclic Carbenes: Efficient Catalysts for Transfer Hydrogenation, beta-Alkylation of Alcohols, and N-Alkylation of Amines.
Gnanamgari, D.; Sauer, E. L. O.; Schley, N. D.; Butler, C.; Incarvito, C. D.; Crabtree, R. H.
Organometallics 2009, 28 (1), 321–325.
DOI: 10.1021/om800821q

Alcohol Cross-Coupling Reactions Catalyzed by Ru and Ir Terpyridine Complexes.
Gnanamgari, D.; Leung, C. H.; Schley, N. D.; Hilton, S. T.; Crabtree, R. H.
Org. Biomol. Chem. 2008, 6 (23), 4442–4445.
DOI: 10.1039/B815547J

Isomeric Forms of Heavier Main Group Hydrides: Experimental and Theoretical Studies of the [Sn(Ar)H]2 (Ar=terphenyl) System.
Rivard, E.; Fischer, R. C.; Wolf, R.; Peng, Y.; Merrill, W. A.; Schley, N. D.; Zhu, Z. L.; Pu, L.; Fettinger, J. C.; Teat, S. J.; Nowik, I.; Herber, R. H.; Takagi, N.; Nagase, S.; Power, P. P.
J. Am. Chem. Soc. 2007, 129 (51), 16197–16208.
DOI: 10.1021/ja076453m