The Stone Research Group in the Vanderbilt Univers

Selected Publications

Reference

Kowal, E.A., Katapati, S., Turo, M., Tretyakova, N., Stone, M. P. “Major Groove Orientation of the (2S)-N6-(2-hydroxy-3-buten-1-yl)-2′-Deoxyadenosine DNA Adduct Induced by 3,4-epoxy-1-Butene.” (2014) Chemical Research in Toxicology.  (27): 1675-1686.

Kowal, E.A., Seneviratne, U., Wickramaratne, S., Doherty, K., Cao, X., Tretyakova, N.Y., Stone, M. P. “Structures of Exocyclic S,S- and R,R N6,N6-(2,3-Dihydroxy-1,4-butadiyl)-2′-deoxyadenosine Adducts Induced by 1,2,3,4-Diepoxybutane.” (2014) Chemical Research in Toxicology. (27): 805-817.

Stavros, K.M., Hawkins, E.K., Rizzo, C.J., Stone, M. P. “Base-Displaced Intercalation of the N2-2-Amino-3-methylimidazo[4,5-f]quinoline-dG Adduct in the NarI Recognition Sequence.” ( 2014) Nucleic Acids Research. (42): 3450-3463.

Kowal, E. A., Lad, R. R., Pallan, P. S., Dhummakupt, E., Wawrzak, Z., Egli, M., Sturla, S. J., Stone, M. P.  “Recognition of O-6-benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.” (2013) Nucleic Acids Research. 41 (15): 7566-7576.

Shanmugam, G., Minko, I. G., Banerjee, S., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Lloyd, R. S., Egli, M., Stone, M. P. “Ring-Opening of the gamma-OH-PdG Adduct Promotes Error-Free Bypass by the Sulfolobus solfataricus DNA Polymerase Dpo4.” (2013) Chemical Research in Toxicology. 26 (9): 1348-1360.

Szulik, M. W., Voehler, M. W., Ganguly, M., Gold, B., Stone, M. P. “Site-Specific Stabilization of DNA by a Tethered Major Groove Amine, 7-Aminomethyl-7-deaza-2 ‘-deoxyguanosine.” (2013) Biochemistry. 52 (43): 7659-7668.

Ganguly, M., Szulik, M. W., Donahue, P. S., Clancy, K., Stone, M. P. “Thermodynamic Signature of DNA Damage: Characterization of DNA with a 5-Hydroxy-2 ‘-deoxycytidine center dot 2 ‘-Deoxyguanosine Base Pair.” (2012) Biochemistry. 51 (9): 2018-2027.

Huang, H., Das, R. S., Basu, A. K., Stone, M. P. “Structures of (5 ‘ S)-8,5 ‘-Cyclo-2 ‘-deoxyguanosine Mismatched with dA or dT.” (2012) Chemical Research in Toxicology.  25 (2): 478-490.

Banerjee, S., Christov, P. P., Kozekova, A., Rizzo, C. J., Egli, M., Stone, M. P. “Replication Bypass of the trans-4-Hydroxynonenal-Derived (6S,8R,11S)-1,N-2-Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IV.” (2012) Chemical Research in Toxicology. 25 (2): 422-435.

Ganguly, M., Szulik, M. W., Donahue, P. S., Clancy, K., Stone, M. P., Gold, B.
“Thermodynamic Signature of DNA Damage: Characterization of DNA with a 5-Hydroxy-2 ‘-deoxycytidine center dot 2 ‘-Deoxyguanosine Base Pair. Pharmazeutische Industrie.” (2012) Pharmazeutische Industrie 74 (2): 2018-2027.

Stone, M. P., Huang, H., Brown, K. L., Shanmugam, G. “Chemistry and Structural Biology of DNA Damage and Biological Consequences.” (2011)  Chemistry & BioDiversity. 8 (9): 1571-1615.

Kowal, E. A., Ganguly, M., Pallan, P. S., Marky, L. A., Gold, B., Egli, M., Stone, M. P. “Altering the Electrostatic Potential in the Major Groove: Thermodynamic and Structural Characterization of 7-Deaza-2 ‘-deoxyadenosine:dT Base Pairing in DNA.” (2011) Journal of Physical Chemistry B. 115 (47): 13925-13934.

Singh, S. K., Szulik, M. W., Ganguly, M., Khutsishvili, I., Stone, M. P., Marky, L. A., Gold, B.  “Characterization of DNA with an 8-oxoguanine modification.” (2011) Nucleic Acids Research. 39 (15): 6789-6801.

Huang, H., Wang, H., Qi, N., Lloyd, R.S., Harris, T.M., Rizzo, C.J., & Stone, M.P. “The Stereochemistry of trans-4-Hydroxynonenal-derived Exocyclic 1,N2-Deoxyguanosine Adducts Modulates Formation of Interstrand Cross-links in the 5′-CpG-3′ Sequence.” (2008) Biochemistry 47, 11457-11472. PMID: 18847226

Minko, I.G., Kozekov, I.D., Harris, T.M., Rizzo, C.J., Lloyd, R.S., & Stone, M.P.  “Chemistry and Biology of DNA Containing 1,N2-Deoxyguanosine Adducts of the alpha,beta-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal ” (2009) Chem. Res. Toxicol. 22, 759-778. 177 references. PMID: 19397281 PMCID: PMC2685875

Voehler, M.W., Eoff, R.L., McDonald, W. H., Guengerich, F.P., & Stone, M.P. “Modulation of the Structure, Catalytic Activity, and Fidelity of African Swine Fever Virus DNA Polymerase X by a Reversible Disulfide Switch.” (2009) J. Biol. Chem. 284, 18434-18444. PMID: 19419958 PMCID: PMC2709365

Xu, W., Merritt, W.K., Nechev, L.V., Harris,T.M., Harris, C.M., Lloyd, R.S., & Stone, M.P. “Solution Structure of the 1,4-Bis(2′-Deoxyadenosin-N6-yl)-2S,3S-butanediol Crosslinked Adduct Arising from Butadiene Diepoxide in the Human N-ras Codon 61 Sequence.” (2007) Chem. Res. Toxicol. 20, 187-198.

Cho, Y.-J., Jacob, J., Voehler, M., Kim, H.-Y., Kozekov, I., Harris, T.M., & Stone, M.P. “Stereochemistry Modulates the Stability of Reduced Interstrand Cross-Links Arising from R- and S-α-CH3-γ-OH-1,N2-Propano-2′-deoxyguanosine in the 5′-CpG-3′ DNA Sequence.” (2007) Biochemistry 46, 2608-2621.

Brown, K.L., Adams, T., Jasti, V.P., Basu, A.K., & Stone, M.P. Interconversion of the cis-5R,6S- and trans-5R,6R-Thymine Glycol Adducts in Duplex DNA.” (2008) J. Am. Chem. Soc. 130, 11701-11710. PMID: 18681438

Brown, K.L., Adams, T., Jasti, V.P., Basu, A.K., & Stone, M.P.0 “Interconversion of the cis-5R,6S- and trans-5R,6R-Thymine Glycol Adducts in Duplex DNA.” (2008) J. Am. Chem. Soc. 130, 11701-11710. PMID: 18681438

Brown, K.L., Basu, A.K., & Stone, M.P. “The cis-(5R,6S)-Thymine Glycol Lesion Occupies the Wobble Position When Mismatched with Deoxyguanosine in DNA.” (2009) Biochemistry 48, 9722-9733. PMID: 19772348 PMCID: PMC2761728