Research Articles

Sung, BH and AM Weaver, “Exosome secretion promotes chemotaxis of cancer cells” Taylor & Francis online.10.1080/19336918.2016.1273307 PMID:28129015

Sinha, Seema et al. “Cortactin Promotes Exosome Secretion by Controlling Branched Actin Dynamics.” The Journal of Cell Biology 214.2 (2016): 197–213. PMC. Web. 13 Feb. 2017.

Mckenzie AJ, Hoshino D, Hong NH, Cha DJ, Frankling JL, Coffey RJ, Patton JG, Weaver AM. “KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes.” Cell Reports, S2211-1247(16)30387-4, 2016. PMID: 27117408.

Koshikawa, N, Hoshino, D*, Taniguchi, H, Minegishi, T, Tomari, T, Nam, S-O, Aoki, M, Sueta, T, Nakagawa, T, Miyamoto, S, Nabeshima, K, Weaver, AM, and M. Seiki., “EphA2 proteolysis converts it from a tumor suppressor to an oncoprotein”, Cancer Research, 75:3327-3339, 2015.

Hong, NH*, Qi, A, and Weaver, AM, “PI(3,5)P2 controls branched actin dynamics at late endosomes by regulating cortactin-actin interactions”, J. Cell Biology, 210: 753-769, 2015. PMCID: PMC4555817.

Cha DJ, Franklin, JL, Dou, Y, Liu Q, Higginbotham, JN, Beckler, MD, Weaver, AM, Vickers, K, Prasad, N, Levy, S, Zhang, B ,Coffey, RJ, and Patton, JG, “KRAS-dependent sorting of miRNA to exosomes”, eLife, 2015. July 1;4. doi: 10.7554/eLife.07197. PMCID: PMC4510696

Sung BH, Ketova T, Hoshino D, Zjilstra A, and Weaver AM, “Directional cell movement through tissues is controlled by exosome secretion.” Nat Communications. 2015 May 13; 6:7164.  PMID: 25968605

Young CD, Zimmerman LJ, Hoshino D, Formisano L, Hanker AB, Gatza ML, Morrison MM, Moore PD, Whitwell CA, Dave B, Stricker T, Bhola NE, Silva GO, Patel P, Brantley-Sieders DM, Levin M, Horiates M, Palma NA, Wang K, Stephens PJ, Perou CM, Weaver AM, O’Shaughnessy JA, Chang JC, Park BH, Liebler DC, Cook RS, Arteaga CL. “Activating PIK3CA mutations induce an EGFR/ERK paracrine signaling axis in basal-like breast cancer.” Mol Cell Proteomics. 2015 May 7. pii: mcp.M115.049783. PMID: 25953087

Christi L. French, Fei Ye, Frank Revetta, Bing Zhang, Robert J. Coffey, Kay Washington, Natasha G. Deane, R. Daniel Beauchamp, Alissa M. Weaver. “Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness.” F1000 Research 2015 April 24. ID

Wirtz ED, Hoshino D, Maldonado AT, Tyson DR, Weaver AM. “Response of head and neck squamos cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies.” JAMA Otolaryngol Head Neck Surg. 2015 Apr 9. PMID: 25855885

Cleghorn WM, Branch KM, Kook S, Arnette C, Bulus N, Zent R, Kaverina I, Gurevich EV, Weaver AM, Gurevich VV. “Arrestins regulate cell spreading and motility via focal adhesion dynamics.” Mol Biol Cell. 2015 Feb 15;26(4):622-35. PMID: 25540425

Riching KM, Cox BL, Salick MR, Pehlke C, Riching AS, Ponik SM, Mass BR, Crone WC, Jiang Y, Weaver AM, Eliceiri KW, Keely PJ. “3D collagen alignment limits protrusions to enhance breast cancer cell persistence.” Biophys J. 2014 Dec 2;107(11):2546-58. PMID: 25468334

Lee B, Zhou X, Riching K, Eliceiri KW, Keely PJ, Guelcher SA, Weaver AM, Jiang Y. “A three-dimensional computational model of collagen network mechanics.”PLoS One. 2014 Nov 11;9(11):e111896. PMID: 25386649

Ryzhov S, Sung BH, Zhang Q, Weaver A, Gumina RJ, Biaggioni I, Feoktistov I, “Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation.” Purinergic Signal. 2014 Sep;10(3):477-86. PMID: 24584483

Hoshino, D, Kirkbride, KC, Costello, K, Clark, ES, Sinha, S, Grega-Larson, N, Tyska, MJ, and Weaver, AM, “Exosome secretion is enhanced by invadopodia and drives invasive behavior”, Cell Reports, Dec 12; 5(5): 1159-1168, 2013. PMID: 24290760

Emily C. Benesh, Paul M. Miller, Elise R. Pfaltzgraff, Nathan E. Grega-Larson, Hillary A. Hager, Bong Hwan Sung*, Xianghu Qu, H. Scott Baldwin, Weaver, AM# and DM Bader#, “Bves and NDRG4 regulate directional cell migration through autocrine extracellular matrix deposition”, MBOC, 24:3496-3510, 2013. # Co-corresponding authors. PMCID: PMC3826988

Bryce, NS, Reynolds, AB, Koleske, AJ, and Weaver, AM, “WAVE2 regulates epithelial morphology and cadherin isoform switching”, PLOS One, 8:e64533,2013.  PMCID: PMC3654908

Hoshino, D., Jourquin, J., Emmons, S.W., Miller, T., Goldgof, M., Costello, K. Tyson, D.R., Brown, b., Lu, Y., Prasad, N.K., Zhang, B., Mills, G.B., Yarbrough, W.G., Quaranta, V., Seiki, M., Weaver, A.M., “Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCa Invasive Signaling Axis”, Science Signaling, 5: 1-14, 2012. PMCID: PMC3583194

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Branch, KM, Hoshino, D, Weaver, AM, “Adhesion rings surround invadopodia and promote maturation”, Biology Open, Advance Online Publication June 15, 2012. PMCID: PMC3507228

Kirkbride, KC, Hong, NH, French, CL, Clark, ES, Jerome, WG, Weaver, AM, “Regulation of Late Endosomal/Lysosomal Maturation andTrafficking by Cortactin Affects Golgi Morphology”, Cytoskeleton, 69: 625-643, 2012. PMCID: PMC3746372

Sung, BH, Xiaodong Xu, Irina Kaverina, and Weaver, A.M., “Cortactin Controls Cell Motility and Lamellipodial Dynamics by Regulating ECM Secretion”,  Current Biology, 21:1-10, 2011. PMCID: PMC3175319

Parekh, A, Ruppender NS, Branch, KM, Sewell, MK, Lin, Jun, Boyer, PD, Candiello, J, Merryman, WD, Guelcher, SA, Weaver, AM, “Sensing and modulation of invadopodia across a wide range of rigidities”, Biophysical Journal, 100:573-82, 2011. PMCID: PMC3030182

Potdar, A.A., Jeon, J., Weaver, A.M., Quaranta, V., and Cummings, P.T., “Human Mammary Epithelial Cells Exhibit A Bimodal Correlated Random Walk Pattern”, PLOS One, 5:e9636, 2010. PMCID: PMC2835765

Rejniak, K.A., Wang, S.E., Bryce, N., Chang, H., Parvin, B., Jourquin, J., Gray, J., Arteaga, C.L., Weaver, A.M., Quaranta, V., Anderson, A.R.A., “Linking Changes in Epithelial Morphogenesis to the Underlying Cancer Mutations Using Computational Modeling”, PLOS Comp Biol, 6: e1000900, 2010. PMCID: PMC2928778

Liu, S., Yamashita, H., Weidow, B., Weaver, A.M., Quaranta, V., “Laminin-332-b1 integrin interactions negatively regulate invadopodia”, J. Cell Phys., 223:134-42, 2010. PMCID: PMC3150482

Anderson, A.R.A., Hassanein, M., Branch, K.M., Lu, J., Lobdell, N.A., Maier, J., Basanta, D., Weidow, B., Narasanna, A, Arteaga, CL, Reynolds, A.B., Quaranta, V., Estrada, L., Weaver, A.M., “Microenvironmental independence associated with tumor progression”, Cancer Research, 69: 8797-8806, 2009, PMCID: PMC2783510

Clark, E.S., Brown, B., Whigham, A.S., Kochaishvili, A., Yarbrough, W.G., Weaver, A.M., “Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon”, Oncogene, 28:431-44, 2009. PMCID: PMC2709457

Alexander, N.R., Branch, K.M., Parekh, A., Clark, E.S., Iwueke, I.C., Guelcher, S.A., Weaver, A.M., “Extracellular matrix rigidity promotes invadopodia activity”, Current Biology, 18:1295-1299, 2008. PMCID: PMC2555969

Potdar, A.A., Lu, J., Jeon, J., Weaver, A.M., Cummings, P.T., “Bimodal Analysis of Mammary Epithelial Cell Migration in Two Dimensions”, Annals of Biomed Engineer, 37:230-245, 2009. PMCID: PMC3586332

Jeon, J., Alexander, N.R., Weaver, A.M., Cummings, P.T., “Protrusion of a Virtual Model Lamellipodium by Actin Polymerization:  A Coarse-grained Langevin Dynamics Model”, Journal of Statistical Physics, 133:79-100, 2008. PMCID: PMC2846375

Wang, S.E., Hinow, P., Bryce, N., Weaver, A.M., Estrada, L., Arteaga, C., Webb, G. F., “A mathematical model quantifies proliferation and motility effects of TGFb on cancer cells”, Computational and Mathematical Methods in Medicine, DOI: 10.1080/17486700802171993, 2009. Not a PubMed J.

Wegner, A.M., Nebhan, C.A., Hu, L., Majumdar, D., Meier, K.M., Weaver, A.M., Webb, D.J., “N-WASp and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses”, Journal of Biological Chemistry, 283:15912-20, 2008. PMCID: PMC2414292

Enderling, H., Alexander, N.R., Clark, E.S., Branch, K.M., Estrada, E., Crooke, C., Jourquin, J., Lobdell, N., Zaman, M., Anderson, A.R.A., Weaver, A.M., “Dependence of invadopodia function on collagen fiber spacing and crosslinking:  computational modeling and experimental evidence”, 95:2203-18, Biophysical Journal, 2008. PMCID: PMC2517013

Clark, E.S. and A.M. Weaver, “A new role for cortactin in invadopodia:  protease secretion”, European Journal of Cell Biology, 87:581-90, 2008. PMCID: PMC2566933

Clark, E.S., Whigham, A., Yarbrough, W., Weaver, A.M., “Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia”, Cancer Research, 67:4227-4235, 2007. PMID: 17483334

Anderson, A.R.A., Weaver, A.M., Cummings, P.T., Quaranta, V., “Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment”, Cell, 127:905-915, 2006. PMID: 17129778

Bryce, N.S., Clark, E.S., Leysath, J.L., Currie, J.C., Webb, D.J., Weaver, A.M., “Cortactin promotes cell motility by enhancing lamellipodial persistence”, Current Biology,15:1276-1285,2005. PMID: 16051170

Brabek, J., Constancio, S.S., Shin, N.-Y., Pozzi, A., Weaver, A.M., Hanks, S.K., “CAS promotes invasiveness of Src-transformed cells”, Oncogene, 23:7406-7415, 2004. PMID: 15273716

Review Articles

Patton, JG, Franklin, JL, Weaver, AM, Vickers, K, Zhang, B, Coffey, RJ, Ansel, KM, Blelloch, R, Gga, A, Huang, B, L’Etoille, N, Raffai, RL, Lai, CP, Krichevsky, AM, Mateescu, B, Greiner, VJ, Hunter, C, Voinnet, O, and MT McManus, “Biogenesis, delivery, and function of extracellular RNA” from special issue: Extracellular RNA Communication Consortium,  Journal of Extracellular Vesicles, 4: 27494, 2015.

Parekh, A and AM Weaver, “Regulation of invadopodia by mechanical signaling”, special review issue: Mechanosensing via Cell-Matrix Adhesions 2016, Experimental Cell Research, in press, 2015.

Hoshino, D., Branch, K.M., and A.M. Weaver, “Signaling inputs to invadopodia and podosomes”, Commentary for Journal of Cell Science, 126:2979-89, 2013. PMID: 23843616

A.M. Weaver, Page, J.M., Guelcher, S.A. and A. Parekh, “Synthetic and Tissue-Derived Models for Studying Rigidity Effects on Invadopodia Activity”, Methods in Molecular Biology, 1046:171-189, 2013. PMID: 23868588

Sung, B.H. and A.M. Weaver, “Regulation of lysosomal secretion by cortactin drives fibronectin deposition and cell motility”, Perspective, Bioarchitecture, 1:257-260, 2011. PMCID: PMC3337126

Sung, B.H. and A.M. Weaver, “Cell-cell fusion: a new function for invadosomes”, Dispatch, Current Biology, 21:R121-123, 2011. PMCID: PMC3596881




Kirkbride, K.C., Sung, B.H., Sinha, S., and A.M. Weaver, “Cortactin a multifunctional regulator of cellular invasiveness”, Cell Adhesion and Migration, Mar 1;5(2), 2011. PMCID: PMC3084985

A.M. Weaver, “Regulation of Cancer Invasion by Reactive Oxygen Species and Tks Family Scaffold Proteins”, Perspective for Science Signaling, 2:pe56, 2009. PMCID: PMC2893140

Parekh, A. and A.M. Weaver, “Regulation of Cancer Invasiveness by the Physical Extracellular Matrix Environment”, Cell Adhesion and Migration, 3:288-292, 2009. PMCID: PMC2712813

A.M. Weaver, “Quick Guide to Invadopodia”, Current Biology, 18:R362-364, 2008. PMID: 18460310

A.M. Weaver, “Cortactin in tumor invasiveness”, Cancer Letters, 265:157-166, 2008. PMCID:PMC2460566

Weaver, A.M., “Invadopodia: specialized cell structures for cancer invasion”, Clin Exp Met, 23:97-105, 2006. PMID: 16830222

Quaranta, V., Weaver, A.M., Cummings, P.C., and Anderson, A.R.A. Mathematical modeling of cancer: The future of prognosis and treatment. Clin Chem Acta, 357:173-179, 2005. PMID: 15907826

Weaver, A.M., “Cytoskeletal interactions with the outside world”, Developmental Cell, 9:35-38, 2005. PMID: 16038069

Weaver, A.M., Young, M.E., Lee, W-l., and Cooper, J.A., “Integration of signals to the Arp2/3 complex”, Current Opinion in Cell Biology, 15:23-30, 2003. PMID: 12517700

Cooper, J.A., Wear, M.A., and Weaver, A.M., “Arp2/3 complex: Advances on the inner workings of a molecular machine”, Cell, 107:703-705, 2001. PMID: 11747805