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Research Articles

Salomon Carlos , Das Saumya , Erdbrügger Uta , Kalluri Raghu , Lim Kiang , Olefsky M , Rice E , Sahoo Susmita , Tao Andy , Vader Pieter , Wang Qun , Weaver M , Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement Endocr Rev. 2022 Apr 21; PMID: 35446389 [PubMed].

Barman B, Sung BH, Krystofiak E, Ping J, Ramirez M, Millis B, Allen R, Prasad N, Chetyrkin S, Calcutt MW, Vickers K, Patton JG, Liu Q, Weaver AM. VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites. Dev Cell. 2022 Apr 25;57(8):974-994.e8. doi: 10.1016/j.devcel.2022.03.012. Epub 2022 Apr 13. PMID: 35421371; PMCID: PMC9075344.

Abner JJ, Franklin JL, Clement MA, Hinger SA, Allen RM, Liu X, Kellner S, Wu J, Karijolich J, Liu Q, Vickers KC, Dedon P, Weaver AM, Coffey RJ, Patton JG. Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m6A consensus sequences. Heliyon. 2021 Dec 2;7(12):e08519. doi: 10.1016/j.heliyon.2021.e08519. PMID: 34934837; PMCID: PMC8654799.

Lim AR, Vincent BG, Weaver AM, Rathmell WK. Sunitinib and Axitinib increase secretion and glycolytic activity of small extracellular vesicles in renal cell carcinoma. Cancer Gene Ther. 2021 Jun 4:10.1038/s41417-021-00345-1. doi: 10.1038/s41417-021-00345-1. Epub ahead of print. PMID: 34088993; PMCID: PMC8642495.

Patel MR, Weaver AM. Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling. Cell Rep. 2021 Mar 9;34(10):108829. doi: 10.1016/j.celrep.2021.108829. PMID: 33691102; PMCID: PMC8002899.

Huang C, Chen L, Savage SR, et al. Clinical Proteomic Tumor Analysis Consortium. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell. 2021 Mar 8;39(3):361-379.e16. doi: 10.1016/j.ccell.2020.12.007. Epub 2021 Jan 7. PMID: 33417831; PMCID: PMC7946781.

Altei WF, Pachane BC, Dos Santos PK, Ribeiro LNM, Sung BH, Weaver AM, Selistre-de-Araújo HS. Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles. Cell Commun Signal. 2020 Sep 25;18(1):158. doi: 10.1186/s12964-020-00630-w. PMID: 32988382; PMCID: PMC7520983.

Harris LA, Beik S, Ozawa PMM, Jimenez L, Weaver AM. Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution. Curr Opin Syst Biol. 2019 Oct;17:24-34. doi: 10.1016/j.coisb.2019.09.005. Epub 2019 Sep 16. PMID: 32642602; PMCID: PMC7343346.

Sung BH, von Lersner A, Guerrero J, Krystofiak ES, Inman D, Pelletier R, Zijlstra A, Ponik SM, Weaver AM. A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells. Nat Commun. 2020 Apr 29;11(1):2092. doi: 10.1038/s41467-020-15747-2. PMID: 32350252; PMCID: PMC7190671.

Weaver AM, Patton JG. Argonautes in Extracellular Vesicles: Artifact or Selected Cargo? Cancer Res. 2020 Feb 1;80(3):379-381. doi: 10.1158/0008-5472.CAN-19-2782. Epub 2019 Nov 29. PMID: 31784424; PMCID: PMC7002258.

Barman, B, Ping, J, Krystofiak, E, Allen, R, Prasad, N, Vickers, K, Patton, JG, Liu, Q, and Weaver, AM, “Biogenesis of RNA-containing extracellular vesicles at endoplasmic reticulum membrane contact sites.”

Sato S, Vasaikar S, Eskaros A, et al. EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling. JCI Insight. 2019;4(23) PMCID: 31661464

Jimenez L, Yu H, Mckenzie A, Franklin JL, Patton JG, Liu Q, and Weaver AM “Quantitative proteomic analysis of small and large extracellular vesicles (EVs) reveals enrichment of adhesion proteins in small EVs.” J Proteome Res. 2019; PMCID: 30608700

Sung, BH and AM Weaver, “Exosome secretion promotes chemotaxis of cancer cells” Cell Adhesion & Migration, 11:187-195, 2017. PMCID: 5351719

Sinha, S, Hoshino, D, Hong, NH, Kirkbride, KC, Grega-Larson, N, Seiki, M, Tyska, MJ, and Weaver AM, “Cortactin promotes exosome secretion by controlling branched actin dynamics.” J. Cell Biol., 214:197-213,2016. PMCID: PMC4949450

McKenzie, AJ, Hoshino, D, Hong, NH, Cha, DJ, Franklin, JL, Coffey, RJ, Patton, JG, and Weaver AM, “Kras-Mek signaling controls ago2 sorting into exosomes”, Cell Reports, 15:978-987, 2016. PMCID: PMC4857875

Koshikawa, N, Hoshino, D, Taniguchi, H, Minegishi, T, Tomari, T, Nam, S-O, Aoki, M, Sueta, T, Nakagawa, T, Miyamoto, S, Nabeshima, K, Weaver, AM, and M. Seiki., “EphA2 proteolysis converts it from a tumor suppressor to an oncoprotein”, Cancer Research, 75:3327-3339, 2015.PMCID: PMC4682662

Hong, NH*, Qi, A, and Weaver, AM, “PI(3,5)P2 controls branched actin dynamics at late endosomes by regulating cortactin-actin interactions”, J. Cell Biology, 210: 753-769, 2015. PMCID: PMC4555817.

Cha, DJ, Franklin, JL, Dou, Y, Liu Q, Higginbotham, JN, Beckler, MD, Weaver, AM, Vickers, K, Prasad, N, Levy, S, Zhang, B ,Coffey, RJ, and Patton, JG, “KRAS-dependent sorting of miRNA to exosomes”, eLife, 2015. doi: 10.7554/eLife.07197. PMCID: PMC4510696

Sung BH, Ketova T, Hoshino D, Zjilstra A#, and Weaver, AM#, “Directional cell movement through tissues is controlled by exosome secretion.” Nature Communications. 6:7164, 2015. #equal contribution and co-corresponding authors. PMCID:PMC4435734

Young, CD, Zimmerman, LJ, Hoshino, D, Formisano, L, Hanker, AB, Gatza, ML, Morrison, MM, Moore, PD, Whitwell, CA, Dave, B, Stricker, T, Bhola, NE, Silva, GO, Patel, P, Brantley-Sieders, DM, Levin, M, Horiates, M, Palma, NA, Wang, K, Stephens, PJ, Perou, CM, Weaver, AM, O’Shaughnessy, JA, Chang, JC, Park, BH, Lieblder, DC, Cook, RS, Arteaga, CL. “Activating PIK3CA mutations induce an EGFR/ERK paracrine signaling axis in basal-like breast cancer.” Molecular Cellular Proteomics, 14:1959-1976, 2015. PMCID: PMC4587316

French, CL, YE, F, Revetta, F, Zhang, B, Coffey, RJ, Washington, MK, Deane, NG, Beauchamp, RD, and Weaver, AM, “Linking patient outcome to high throughput protein expression data identifies regulators of colorectal adenocarcinoma aggressiveness”, F1000Research 2015, 4:99 PMCID: PMC4457132

Wirtz, ED, Hoshino, D, Maldonado, A, Tyson, DR, and Weaver, AM, “Response of Head and Neck Squamous Cell Carcinoma Cells Carrying PIK3CA Mutations to Selected Targeted Therapies”, JAMA Otolaryngol Head Neck Surg, 141:543-549, 2015. PMCID: PMC4474763

Cleghorn, WM, Branch, KM, Kook, S, Arnette, C, Bulus, N, Zent R, Kaverina I, Gurevich, EV, Weaver, AM, Gurevich, VV. “Arrestins regulate cell spreading and motility via focal adhesion dynamics.” Molecular Biology of the Cell. 26:622-635, 2015. PMCID: PMC4325834

Riching, KM, Cox, BL, Salick, MR, Pehlke, C, Riching, AS, Ponik, SM, Mass, BR, Crone, WC, Jiang, Y, Weaver, AM, Eliceiri, KW, Keely, PJ. “3D collagen alignment limits protrusions to enhance breast cancer cell persistence.” Biophysical Journal, 107:2546-2558, 2014. PMCID: PMC4255204

Lee. B, Zhou, X, Riching, K, Eliceiri, KW, Keely PJ, Guelcher SA, Weaver, AM, Jiang, Y. “A three-dimensional computational model of collagen network mechanics.” PLOS One, 9(11): e111896, 2014. PMCID: PMC4227658

Ryzhov, S, Sung, BH, Zhang, Q, Weaver, AM, Gumina, RJ, Biagioni, I, And Feokstitov, I, “Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation”, Purinergic Signaling, 10(3): 477-486, 2014. PMCID: PMC4152448

Hoshino, D, Kirkbride, KC, Costello, K, Clark, ES, Sinha, S, Grega-Larson, N, Tyska, MJ, and Weaver, AM, “Exosome secretion is enhanced by invadopodia and drives invasive behavior”, Cell Reports,  5:1159-1168, 2013. PMCID:PMC3873329

Benesh, EC, Miller, PM, Pfaltzgraff, ER, Grega-Larson, NE, Hager, HA, Sung, BH,  Qu, X, Baldwin, HS, Weaver, AM# and Bader, DM#, “Bves and NDRG4 regulate directional cell migration through autocrine extracellular matrix deposition”, MBOC, 24:3496-3510, 2013. # Co-corresponding authors. PMCID: PMC3826988

Bryce, NS, Reynolds, AB, Koleske, AJ, and Weaver, AM, “WAVE2 regulates epithelial morphology and cadherin isoform switching”, PLOS One, 8:e64533,2013.  PMCID: PMC3654908

Hoshino, D, Jourquin, J, Emmons, SW, Miller, T, Goldgof, M, Costello, K, Tyson, DR, Brown, B, Lu, Y, Prasad, NK, Zhang, B, Mills, GB, Yarbrough, WG, Quaranta, V, Seiki, M, Weaver, AM, “Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCa Invasive Signaling Axis”, Science Signaling, 5: 1-14, 2012. PMCID: PMC3583194

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Branch, KM, Hoshino, D, Weaver, AM, “Adhesion rings surround invadopodia and promote maturation”, Biology Open, Advance Online Publication June 15, 2012. PMCID: PMC3507228

Kirkbride, KC, Hong, NH, French, CL, Clark, ES, Jerome, WG, Weaver, AM, “Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects golgi morphology”, Cytoskeleton, 69: 625-643, 2012. PMCID: PMC3746372

Sung, BH, Xiaodong, Xu, Kaverina, I,  and Weaver, AM, “Cortactin Controls Cell Motility and Lamellipodial Dynamics by Regulating ECM Secretion”,  Current Biology, 21:1-10, 2011. PMCID: PMC3175319

Parekh, A, Ruppender, NS, Branch, KM, Sewell, MK, Lin, J, Boyer, PD, Candiello, J, Merryman, WD, Guelcher, SA, Weaver, AM, “Sensing and modulation of invadopodia across a wide range of rigidities”, Biophysical Journal, 100:573-82, 2011. PMCID: PMC3030182

Potdar, AA, Jeon, J, Weaver, AM, Quaranta, V, and Cummings, PT, “Human Mammary Epithelial Cells Exhibit A Bimodal Correlated Random Walk Pattern”, PLOS One, 5:e9636, 2010. PMCID: PMC2835765

Rejniak, KA, Wang, SE, Bryce, N, Chang, H, Parvin, B, Jourquin, J, Gray, J, Arteaga, CL, Weaver, AM, Quaranta, V, Anderson, ARA, “Linking Changes in Epithelial Morphogenesis to the Underlying Cancer Mutations Using Computational Modeling”, PLOS Comp Biol, 6: e1000900, 2010. PMCID: PMC2928778

Liu, S, Yamashita, H, Weidow, B, Weaver, AM, Quaranta, V, “Laminin-332-b1 integrin interactions negatively regulate invadopodia”, J. Cell Phys., 223:134-42, 2010. PMCID: PMC3150482

Anderson, ARA, Hassanein, M, Branch, KM, Lu, J, Lobdell, NA, Maier, J, Basanta, D, Weidow, B, Narasanna, A, Arteaga, CL, Reynolds, AB, Quaranta, V, Estrada, L, Weaver, AM, “Microenvironmental independence associated with tumor progression”, Cancer Research, 69: 8797-8806, 2009, PMCID: PMC2783510

Clark, ES, Brown, B, Whigham, AS, Kochaishvili, A, Yarbrough, WG, Weaver, AM, “Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon”, Oncogene, 28:431-44, 2009. PMCID: PMC2709457

Alexander, NR, Branch, KM, Parekh, A, Clark, ES, Iwueke, IC, Guelcher, SA, Weaver, AM, “Extracellular matrix rigidity promotes invadopodia activity”, Current Biology, 18:1295-1299, 2008. PMCID: PMC2555969

Potdar, AA, Lu, J, Jeon, J, Weaver, AM, Cummings, PT, “Bimodal Analysis of Mammary Epithelial Cell Migration in Two Dimensions”, Annals of Biomed Engineer, 37:230-245, 2009. PMCID: PMC3586332

Jeon, J, Alexander, NR, Weaver, AM, Cummings, PT, “Protrusion of a virtual model lamellipodium by actin polymerization: a coarse-grained Langevin Dynamics model”, Journal of Stastical Physics, 133:79-00, 2008. PMCID: PMC2846375

Wang, SE, Hinow, P, Bryce, N, Weaver, AM, Estrada, L, Arteaga, C, Webb, G F, “A mathematical model quantifies proliferation and motility effects of TGFb on cancer cells”, Computational and Mathematical Methods in Medicine, DOI: 10.1080/17486700802171993, 2009. Not a PubMed J.

Wegner, AM, Nebhan, CA, Hu, L, Majumdar, D, Meier, KM, Weaver, AM, Webb, DJ, “N-WASp and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses”, Journal of Biological Chemistry, 283:15912-20, 2008. PMCID: PMC2414292

Enderling, H, Alexander, NR, Clark, ES, Branch, KM, Estrada, E, Crooke, C, Jourquin, J, Lobdell, N, Zaman, M, Anderson, ARA, Weaver, A.M., “Dependence of invadopodia function on collagen fiber spacing and crosslinking:  computational modeling and experimental evidence”, 95:2203-18, Biophysical Journal, 2008. PMCID: PMC2517013

Clark, ES and AM Weaver, “A new role for cortactin in invadopodia: protease secretion”, European Journal of Cell Biology, 87:581-90, 2008. PMCID: PMC2566933

Clark, ES, Whigham, A, Yarbrough, W, Weaver, AM, “Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia”, Cancer Research, 67:4227-4235, 2007. PMID: 17483334

Anderson, ARA, Weaver, AM, Cummings, PT, Quaranta, V, “Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment”, Cell, 127:905-915, 2006. PMID: 17129778

Bryce, NS, Clark, ES, Leysath, JL, Currie, JC, Webb, DJ, Weaver, AM, “Cortactin promotes cell motility by enhancing lamellipodial persistence”, Current Biology,15:1276-1285,2005. PMID: 16051170

Brabek, J, Constancio, SS, Shin, N-Y, Pozzi, A, Weaver, AM, Hanks, SK, “CAS promotes invasiveness of Src-transformed cells”, Oncogene, 23:7406-7415, 2004. PMID: 15273716

Review Articles

Sung BH, Parent CA, Weaver AM. Extracellular vesicles: Critical players during cell migration. Dev Cell. 2021 Jul 12;56(13):1861-1874. doi: 10.1016/j.devcel.2021.03.020. Epub 2021 Apr 2. PMID: 33811804; PMCID: PMC8282723.

Sato, S and AM weaver, “Extracellular vesicles: important collaborators in
cancer progression” Essays In Biochemistry, 10.1042, 2018. PMID: 29666212

Maas SL, Breakefield XO, Weaver AM, “Extracellular Vesicles: Unique Intercellular Delivery Vehicles.” Trends in Cell Biology. 2017 Mar;27(3):172-188. doi:   10.1016/j.tcb.2016.11.003. Epub 2016 Dec 13. PMCID: PMC5318253

Patton, JG, FranklWeaver Laboratory in, JL, Weaver, AM, Vickers, K, Zhang, B, Coffey, RJ, Ansel, KM, Blelloch, R, Gga, A, Huang, B, L’Etoille, N, Raffai, RL, Lai, CP, Krichevsky, AM, Mateescu, B, Greiner, VJ, Hunter, C, Voinnet, O, and MT McManus, “Biogenesis, delivery, and function of extracellular RNA” from special issue: Extracellular RNA Communication Consortium,  Journal of Extracellular Vesicles, 4: 27494, 2015. PMCID: PMC4553255

Parekh, A and AM Weaver, “Regulation of invadopodia by mechanical signaling”, Experimental Cell Research, 343:89-95, 2016. PMCID: PMC4851576

Hoshino, D, Branch, KM, and AM Weaver, “Signaling inputs to invadopodia and podosomes”, Commentary for Journal of Cell Science, 126:2979-89, 2013. PMCID: PMC3711196

Weaver, AM, Page, JM, Guelcher, SA and A. Parekh, “Synthetic and Tissue-Derived Models for Studying Rigidity Effects on Invadopodia Activity”, Methods in Molecular Biology, 1046:171-189, 2013. PMID: 23868588

Sung, B.H. and A.M. Weaver, “Regulation of lysosomal secretion by cortactin drives fibronectin deposition and cell motility”, Perspective, Bioarchitecture, 1:257-260, 2011. PMCID: PMC3337126

Sung, B.H. and A.M. Weaver, “Cell-cell fusion: a new function for invadosomes”, Dispatch, Current Biology, 21:R121-123, 2011. PMCID: PMC3596881

Kirkbride, KC, Sung, BH, Sinha, S, and AM Weaver, “Cortactin: a multifunctional regulator of cellular invasiveness”, Cell Adhesion and Migration, 5(2): 187-198,  2011. PMCID: PMC3084985

A.M. Weaver, “Regulation of Cancer Invasion by Reactive Oxygen Species and Tks Family Scaffold Proteins”, Perspective for Science Signaling, 2:pe56, 2009. PMCID: PMC2893140

Parekh, A. and A.M. Weaver, “Regulation of Cancer Invasiveness by the Physical Extracellular Matrix Environment”, Cell Adhesion and Migration, 3:288-292, 2009. PMCID: PMC2712813

A.M. Weaver, “Quick Guide to Invadopodia”, Current Biology, 18:R362-364, 2008. PMID: 18460310

A.M. Weaver, “Cortactin in tumor invasiveness”, Cancer Letters, 265:157-166, 2008. PMCID:PMC2460566

Weaver, A.M., “Invadopodia: specialized cell structures for cancer invasion”, Clin Exp Met, 23:97-105, 2006. PMID: 16830222

Quaranta, V, Weaver, AM, Cummings, PC, and Anderson, ARA, “Mathematical modeling of cancer: The future of prognosis and treatment”, Clin Chem Acta, 357:173-179, 2005. PMID: 15907826

Weaver, A.M., “Cytoskeletal interactions with the outside world”, Developmental Cell, 9:35-38, 2005. PMID: 16038069

Weaver, A.M., Young, M.E., Lee, W-l., and Cooper, J.A., “Integration of signals to the Arp2/3 complex”, Current Opinion in Cell Biology, 15:23-30, 2003. PMID: 12517700

Cooper, J.A., Wear, M.A., and Weaver, A.M., “Arp2/3 complex: Advances on the inner workings of a molecular machine”, Cell, 107:703-705, 2001. PMID: 11747805