Romario’s paper describing cooling-triggered release of an NSAID from an implantable device is published in ACS Biomaterials Science & Engineering!
Romario’s work shows how one can use relatively minor levels of cooling (achievable via application of an ice pack to the skin, for example) to cause a physically crosslinked thermoresponsive polymer within an implant to undergo a gel-to-sol transition and thereby release a sequestered payload (in this case Celecoxib, an NSAID). Very cool work! (Pun very much intended)
https://doi.org/10.1021/acsbiomaterials.5c00867