Publications

1. Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nat Commun. 2019 10(1):187. doi: 10.1038/s41467-018-08129-2
2. Grandjean JM, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing. in print at ACS Chemical Biology, BioRxiv. Dec. 2018. doi: https://doi.org/10.1101/499046
3. [PREPRINT] Plate, L, Rius, B, Nguyen B, Genereux JC, Kelly, JW, Wiseman, RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. BioRxiv. July 2018. doi: https://doi.org/10.1101/381525
4. Paxman, RJ, Plate, L, Blackwood EA, Glembotski, CC, Powers, ET, Wiseman, RL, Kelly, JW. A Small Molecule that Preferentially Activates the ATF6 Pathway of the Unfolded Protein Response is Metabolically Activated to Selectively Modify Endoplasmic Reticulum Proteins. Elife. 2018 7: e37168. doi: 10.7554/eLife.37168
5. Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal. 2018 11(517). pii: eaan5785. doi: 10.1126/scisignal.aan5785
6. Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. “Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. J Am Chem Soc. 2018 140(1): 200-210. doi: 10.1021/jacs.7b08366
7. Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Sci Transl Med. 2017 407 pii: eaam7621. doi: 10.1126/scitranslmed.aam7621
8. Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly
   JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone
   ERdj3/DNAJB11 assembles and functions as a tetramer. EMBO J. 2017 36(15). pii:
   e201695616. doi: 10.15252/embj.201695616.
9.  Plate L, Wiseman RL. Regulating Secretory Proteostasis through the Unfolded
   Protein Response: From Function to Therapy. Trends Cell Biol. 2017 Jun 21. pii:
   S0962-8924(17)30085-5. doi: 10.1016/j.tcb.2017.05.006. [Epub ahead of print]
10. Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK. Regulated
    in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and
    Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of
    Experimental Osteoarthritis. Arthritis Rheumatol. 2017 69 (7):1418-1428. doi:
    10.1002/art.40104.
11. Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC,
    Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P,
    Hodder P, Wiseman RL, Kelly JW. Small molecule proteostasis regulators that
    reprogram the ER to reduce extracellular protein aggregation. Elife. 2016 Jul
    20;5. pii: e15550. doi: 10.7554/eLife.15550.
12. Plate L, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control.
    Elife. 2016 Jul 20;5. pii: e18431. doi: 10.7554/eLife.18431.
13. Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A,
    Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly
    JW. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through
    Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. J Am Chem Soc.
    2016 Jun 15;138(23):7353-64. doi: 10.1021/jacs.6b02960.
14. Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL.
    Unfolded protein response activation reduces secretion and extracellular
    aggregation of amyloidogenic immunoglobulin light chain. Proc Natl Acad Sci U S
    A. 2014 Sep 9;111(36):13046-51. doi: 10.1073/pnas.1406050111.
15. Plate L, Marletta MA. Phosphorylation-dependent derepression by the response
    regulator HnoC in the Shewanella oneidensis nitric oxide signaling network. Proc
    Natl Acad Sci U S A. 2013 Nov 26;110(48):E4648-57. doi: 10.1073/pnas.1318128110.
16. Plate L, Marletta MA. Nitric oxide-sensing H-NOX proteins govern bacterial
    communal behavior. Trends Biochem Sci. 2013 Nov;38(11):566-75. doi:
    10.1016/j.tibs.2013.08.008.
17. Ivanisevic J, Zhu ZJ, Plate L, Tautenhahn R, Chen S, O’Brien PJ, Johnson CH,
    Marletta MA, Patti GJ, Siuzdak G. Toward ‘omic scale metabolite profiling: a dual
    separation-mass spectrometry approach for coverage of lipid and central carbon
    metabolism. Anal Chem. 2013 Jul 16;85(14):6876-84. doi: 10.1021/ac401140h.
18. Plate L, Marletta MA. Nitric oxide modulates bacterial biofilm formation
    through a multicomponent cyclic-di-GMP signaling network. Mol Cell. 2012 May
    25;46(4):449-60. doi: 10.1016/j.molcel.2012.03.023.
19. Weinert EE, Plate L, Whited CA, Olea C Jr, Marletta MA. Determinants of
    ligand affinity and heme reactivity in H-NOX domains. Angew Chem Int Ed Engl.
    2010;49(4):720-3. doi: 10.1002/anie.200904799.
20. Carlson HK, Plate L, Price MS, Allen JJ, Shokat KM, Marletta MA. Use of a
    semisynthetic epitope to probe histidine kinase activity and regulation. Anal
    Biochem. 2010 Feb 15;397(2):139-43. doi: 10.1016/j.ab.2009.10.009.
21. Hassan AQ, Wang Y, Plate L, Stubbe J. Methodology to probe subunit
    interactions in ribonucleotide reductases. Biochemistry. 2008 Dec
    9;47(49):13046-55. doi: 10.1021/bi8012559.
22. Gianolio DA, Philbrook M, Avila LZ, Young LE, Plate L, Santos MR, Bernasconi
    R, Liu H, Ahn S, Sun W, Jarrett PK, Miller RJ. Hyaluronan-tethered opioid depots:
    synthetic strategies and release kinetics in vitro and in vivo. Bioconjug Chem.
    2008 Sep;19(9):1767-74. doi: 10.1021/bc8000479.