The Tate Lab


OrcID: Ann Tate

*indicates corresponding author; 1Maiden name;  2Undergraduate student.


Asgari, D.* and Tate, A.T.* 2024. Positioning of negative feedback loops within immune signaling pathways influences host fitness through noise in AMP expression. BioRxiv. DOI:

Martin, R.A. and Tate, A.T.*. 2023. Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signaling networks. BioRxiv. DOI:

Birnbaum, S.S.L, Schulz, N.K.E., and Tate, A.T.*. 2022. Interactions among evolved pesticide resistance and pesticide exposure on immunity against pathogens. BioRxiv. DOI:

Birnbaum, S.S.L*, Schulz, N.K.E., Garrett, D.S., and Tate, A.T.*. 2022Experimental evolution of insect resistance to two pesticide classes reveals mechanistic diversity and context-dependent fitness costs. BioRxiv. DOI:


Critchlow, J.T., Prakash, A., Zhong, K.Y.², and Tate, A.T.*. 2024. Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling. PLoS Pathogens. 20(2): e1012049. DOI:


Schulz, N.K.E.*, Stewart, C.M.2, and Tate, A.T.*. 2023. Female investment in terminal reproduction or somatic maintenance depends on infection dose. Ecological Entomology. 48(6):714- 724. DOI:

Williams, A., Ngo, T.M., Figueroa, V.² and Tate, A.T.* 2023. The effect of developmental pleiotropy on the evolution of insect immune genes. Genome Biology and Evolution. 15(3):evad044. DOI:

Martin, R.A. and Tate, A.T.* 2023. Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution. PLoS Computational Biology. 19(4): e1010445 DOI:

Chora, Â.F., S. Marques, J.L. Gonçalves, P. Lima, D. Gomes da Costa, D. Fernandez-Ruiz, M.I. Marreiros, P. Ruivo, T. Carvalho, R.M. Ribeiro, K. Serre, W.R. Heath, B. Silva-Santos, A.T. Tate, and M.M. Mota. 2023. Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis. Immunity. 56(3): 592-605.


Tate, A.T.* and Van Cleve, J. 2022. Bet-hedging in innate and adaptive immune systems, Evolution, Medicine, & Public Health. 10(1):256-265.

Rovenolt, F.H.2 and Tate, A.T.* 2022. The impact of coinfection dynamics on host competition and coexistence. The American Naturalist. 199(1):91-107. DOI: 10.1086/717180

Lazzaro, B. and Tate, A.T. 2022. Balancing sensitivity, risk, and immunopathology in immune regulation. Current Opinion in Insect Science. 50:100874. DOI:

Tate, A.T.* and Schulz, N.K.E. 2022. The within-host ecology of insects and their parasites: integrating experiments and mathematical models. Current Opinion in Insect Science. 49:37-41 . DOI: 10.1016/j.cois.2021.11.001.


Tate, A.T.*, Perry, A.2, Jent, D.G. 2021. Larvae and adults exhibit contrasting patterns of immune gene expression and infection resistance in wild flour beetle populations. Ecological Entomology. 46(5):1230-1235. DOI: 10.1111/een.13066.


Gitschlag, B. L., Tate, A.T., and Patel, M.R. 2020. Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection. eLife 9:e56686. DOI: 10.7554/eLife.56686

Greischar, M.A., Alexander, H.K., Bashey, F., Bento, A.I., Bhattacharya, A., Bushman, M., Childs, L.M., Daversa, D.R., Day, T., Faust, C.L., Gallagher, M.E., Gandon, S., Glidden, C.K., Halliday, F.W., Hanley, K.A., Kamiya, T.,, Read, A.F., Schwabl, P., Sweeny, A.R., Tate, A.T., Thompson, R.N., Wale, N., Wearing, H.J., Yeh, P., and Mideo, N. 2020. Evolutionary consequences of feedbacks between within-host competition and disease control. Evolution, Medicine, & Public Health. 1(2020):30-34. DOI: 10.1093/emph/eoaa004


Jent, D.G, Perry, A. 2, Critchlow, J.T., Tate, A.T.2019. Natural variation in the contribution of microbial density to inducible immune dynamics. Molecular Ecology. 28:5360-5372. DOI: 10.1111/mec.15293.

Critchlow, J., Norris, A., Tate, A.T.* 2019. The legacy of larval infection on immunological dynamics over metamorphosis. Philosophical Transactions of the Royal Society B. 374(1783): 20190066. DOI: 10.1098/rstb.2019.0066.

Tate, A.T.2019. The role of multiple infections on immunological variation in wild populations. mSystems. 4(3):e0009:19. DOI: 10.1128/mSystems.00099-19.


Shaw, D.K.*, Tate, A.T.*, Schneider, D.S., Levashina, E.A., Kagan, J.C., Pal, U., Fikrig, E., Pedra, J.H.F*. 2018. Vector immunity and evolutionary ecology: the harmonious dissonance. Trends in Immunology. 39(11):862-873. DOI: 10.1016/


Graham, A.L., and Tate, A.T. 2017. Insight: Are we immune, by chance? eLife. 6: e32783. DOI: 10.7554/eLife.32783

Metcalf, C.J.E., Tate, A.T., and Graham, A.L. 2017. Demographically framing trade-offs 
between sensitivity and specificity illuminates selection on immunity. 
Nature Ecology and Evolution. 1(11), 1766-1772. DOI: 10.1038/s41559-017-0315-3

Tate, A.T.* and Graham, A.L. 2017. Dissecting the contributions of time and microbe density to variation in immune gene expression. Proceedings of the Royal Society B. 284(1859). DOI: 10.1098/rspb.2017.0727

Luu, H.2 and Tate, A.T.* 2017. Recovery and immune priming modulate the evolutionary trajectory of infection-induced reproductive strategies. Journal of Evolutionary Biology. 30(9): 1748–1762. DOI: 10.1111/jeb.13138

Tate, A.T.*, Andolfatto, P., Demuth, J., and Graham, A.L. 2017. The within-host 
dynamics of infection in trans-generationally primed flour beetles. 
Molecular Ecology. 26(14), 3794-3807. DOI: 10.1111/mec.14088

Kennedy2, M., Graham, A.L, and Tate, A.T.* 2017. Relative contributions of environmental and maternal factors to trans-generational immune priming in T. castaneum. Ecological Entomology. 42(1):100-104. DOI: 10.1111/een.12357

Tate, A.T.* 2017. A general model for the influence of immune priming on disease prevalence. Oikos. 126(3): 350-360. DOI: 10.1111/oik.03274


Tate, A.T.* 2016. The interaction of immune priming with different modes of disease transmission. Frontiers in Microbiology. 7(1102). DOI: 10.3389/fmicb.2016.01102

Schneider, D.S. and Tate, A.T. 2016. Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties. Current Biology. 26(12): R503-505. DOI: 10.1016/j.cub.2016.05.016

Louie, A., Song, K.H., Hotson, A., Tate, A.T., and Schneider, D.S. 2016. How many parameters does it take to describe disease tolerance? PLoS Biology. 14(4), e1002435. DOI: 10.1371/journal.pbio.1002435

Torres, B.Y., Oliveira, J.H.M., Tate, A.T., Rath, P. Cumnock, K, and Schneider, D.S. 2016. Tracking resilience to infections by mapping disease space. PLoS Biology. 14(4), e1002436. DOI: 10.1371/journal.pbio.1002436

2015 and earlier

Tate, A.T.* and Graham, A.L. 2015. Dynamic patterns of parasitism and immunity across host development influence optimal strategies of resource allocation. The American Naturalist. 186(4): 495-512. DOI: 10.1086/682705

Tate, A.T.* and Graham, A.L. 2015. Trans-generational priming of resistance in wild flour beetles reflects the primed phenotypes of laboratory populations and is inhibited by co-infection with a common parasite. Functional Ecology. 29(8), 1059-1069. DOI: 10.1111/1365-2435.12411

Tate, A.T.* and Rudolf, V.H.W. 2012.  Impact of life stage – specific immune priming on invertebrate disease dynamics. Oikos 121(7): 1083-1092. DOI: 10.1111/j.1600-0706.2011.19725.x

Thomas, A.M.1 and Rudolf, V.H.W. 2010. Challenges of metamorphosis in invertebrate hosts: Maintaining parasite resistance across life-history stages. Ecological Entomology. 35(2): 200-205. DOI: 10.1111/j.1365-2311.2009.01169.x

Abbott, A.N., Guidry, T.V., Welsh, K.J., Thomas, A.M1., Kling, M.A., Hunter, R.L., Actor, J.K. 2009.11-Hydroxysteroid Dehydrogenases are regulated during the pulmonary granulomatous response to the Mycobacterial glycolipid Trehalose-6,6-dimycolate. Neuroimmunomodulation. 16(3):147-154.