VINSE Colloquium Series: “Silicon-integrated nano-dialysis platform for monitoring brain chemistry” Dr. Yurii Vlasov, University of Illinois 12/9/2022
Dr. Yurii Vlasov
John Bardeen Endowed Chair in Electrical and Computer Engineering and Physics
University of Illinois
Noon, FGH 134
Lunch served to first 60 attendees
Abstract. Monitoring local concentrations of neurochemicals with high temporal and chemical resolution in-vivo is critical for correlating neural circuit functionality to behavior and for treatment of neurological disorders. Adopting best practices of the microelectronics industry, the developed silicon microfluidics technology is based on verified library of standard components including deeply scaled silicon microfluidic channels, ultra-low flow pL-scale nanodialysis with droplet microfluidics, integrated electrochemical cells, that are augmented with drug delivery, electrophysiology, and optogenetic stimulation. Developed nanodialysis probes demonstrate attomole level of detection with superior temporal and spatial resolution.
Time permits, I will touch upon couple of other complementary activities in my lab aimed at reverse engineering the brain: in-vivo neurobiological experiments with massive recording and manipulation of brain activity, and development of machine-learning algorithms to analyze these large neural datasets.
Bio. Dr. Yurii Vlasov is a John Bardeen Chair in Electrical and Computer Engineering at the University of Illinois at Urbana-Champaign. At the UIUC he established the Integrated Neurotechnology lab devoted to development of advanced engineering approaches aimed at reverse engineering of brain circuits. Prior to joining UIUC in 2016, Vlasov held various research and managerial positions with IBM Research developing silicon nanophotonics. Under his leadership the technology has been deployed for manufacturing to enable high-performance optical connectivity. Vlasov has been elected to the National Academy of Engineering, and a Fellow of OSA, APS, IEEE.