17th Annual Nanoscience & Nanotechnology Forum – NanoDay! 10/19/16 – Keynote Speaker – Mark Saltzman
17th Annual Nanoscience and Nanotechnology Forum
Wednesday, October 19, 2016
A yearly forum for faculty, postdocs, and students engaged in nanoscience and nanotechnology research.
STUDENT LIFE CENTER
1:00 – 1:10 Welcome Sandra Rosenthal, Director of VINSE
1:10 – 1:20 New Tool in VINSE: Helios FIB SEM Anthony Hmelo, VINSE
1:20 – 1:40 Ultrafast Vibrational Spectroscopies to Probe Systems at the Interface of Biology and Nanotechnology Lauren Buchanan, Chemistry
1:40 – 2:00 Using Silicon Nanophotonics to Achieve Extreme Light-Matter Interaction Sharon Weiss, Electrical Engineering
2:00 – 2:20 Contact Thermal Resistance between Individual Carbon Nanotubes Deyu Li, Mechanical Engineering
FEATHERINGILL HALL
2:25 – 3:10 POSTER SESSION
3:10 – 3:30 The Optoelectronic Properties of Ternary I-III-VI2 Semiconductor Nanocrystals and Their Hybrids Alice Leach, Graduate Student, Interdisciplinary Materials Science
3:30 – 3:50 Low-dimensional Materials for Optoelectronics and Bioelectronics Yaqiong Xu, Electrical Engineering
3:50 – 4:10 Polymeric siRNA Nanocarriers for Breast Cancer Therapy Craig Duvall, Biomedical Engineering
4:20 – 5:00 POSTER SESSION
5:00 – 6:00 KEYNOTE SPEAKER Polymer Nanoparticles for Drug Delivery, Gene Editing, and Cell Targeting W. Mark Saltzman, Biomedical Engineering, Yale University
6:00 RECEPTION AND POSTER AWARDS
Abstract. The primary goal of nanomedicine—using materials such as polymer nanoparticles—is to improve clinical outcomes. For example, targeted nanoparticles can be engineered to reduce non-productive distribution while improving diagnostic and therapeutic efficacy. Paradoxically, as the field has matured, the notion of ‘targeting’ has been minimized to the concept of increasing affinity of a nanoparticle for its target, and most applications have focused on intravenous delivery, where this kind of targeting is most difficult to achieve. Here, I present examples of alternate approaches, in which nanoparticle design is used for treatment of brain tumors, targeted correction of a single-gene disorder, long-lasting, safe prevention of UV-mediated DNA damage in skin, and antibody-mediated targeting of inflamed endothelium. These examples all involve targeted nanoparticles, but with unique designs that guide their biological activity.
Bio. Mark Saltzman is an engineer and educator. Dr. Saltzman’s research in the fields of drug delivery, biomaterials, nanobiotechnology, and tissue engineering is described in over 250 research papers and 15 patents. He is the author of three textbooks: Biomedical Engineering (Second Edition, 2015), Tissue Engineering (2004), and Drug Delivery (2001).
The grandson of Iowa farmers, Mark Saltzman earned degrees in chemical engineering (B.S. Iowa State University 1981 and M.S. MIT 1984) and medical engineering (Ph.D. MIT 1987). He served on the faculty at Johns Hopkins (1987-1996), Cornell (1996-2002), where he was the first BP Amoco/H. Laurance Fuller Chair, and Yale, where he has been the Goizueta Foundation Professor since 2002. He was named the founding chair of the Yale’s Department of Biomedical Engineering in 2003, and served in that role until 2015.
Dr. Saltzman has been recognized for his excellence in research and teaching. He received the Mines Medal (2014); the Camille and Henry Dreyfus Foundation Teacher-Scholar Award (1990); the Allan C. Davis Medal (1995); the Controlled Release Society Young Investigator Award (1996); and the Professional Progress in Engineering Award from Iowa State University (2000). He has been elected a Fellow of the National Academy of Inventors (2014); Fellow of the American Institute for Medical and Biological Engineering (1997); a Fellow of the Biomedical Engineering Society (2010); a Member of the Connecticut Academy of Science & Engineering (2012); and a Member of the National Academy of Medicine (2014).
Dr. Saltzman has taught dozens of college courses including Heat & Mass Transfer, Material & Energy Balances, Engineering of Drug Delivery, Physiological Systems, and Molecular Transport & Intervention in the Brain. His course Frontiers of Biomedical Engineering is available to everyone through Open Yale Courses (http://oyc.yale.edu).
- Conjugation of lipophilic albumin-binding moiety to siRNA improves carrier-free in vivo pharmacokinetics and mediates prolonged gene silencing in tumors
Presented by: Samantha Sarett, Biomedical Engineering (Duvall) - Tagging synaptic vesicles for single molecule imaging with monovalent quantum dot-aptamer conjugates
Presented by: Kristina Kitko, Interdisciplinary Materials Science (Zhang) - A Transferable Multi-Resolution Coarse-Grained Model for Amorphous Silica Nanoparticles
Presented by: Andrew Summers, Chemical Engineering (McCabe/Cummings) - Evaluating the role of polymer structure on cell uptake and endosomal escape of nanopolyplexes for peptide drug delivery
Presented by: Eric Dailing, Biomedical Engineering (Duvall) - Scalable Fabrication of Shape-Engineered Porous Silicon Nanoparticles by Direct Imprintation
Presented by: Joshua Fain, Electrical Engineering (Weiss) - Spatiotemporal Control of Morphogen Delivery to Stem Cells in a Large-Scale Hydrogel
Presented by: Brian O’Grady, Interdisciplinary Materials Science (Bellan) - Development of Dual Release Drug Delivery Platforms
Presented by: Laken Kendrick, Chemistry (Harth) - Carbon Nanotube Reinforced Multifunctional Energy Storage Composites
Presented by: Andrew Westover, Interdisciplinary Materials Science (Pint) - Targeted Nanoparticles for Delivery of siRNA to Sites of Early Onset Post-Traumatic Osteoarthritis
Presented by: Sean Bedingfield, Biomedical Engineering (Duvall) - Surface-Initiated Polymerization of Ionic Liquids: Effect of Anion on Ion Transfer in Surface-Tethered Poly(Ionic Liquids)
Presented by: Ian Njoroge, Chemical Engineering (Jennings) - Femtosecond Optical Modulation with VO2-Si Hybrid Devices
Presented by: Kent Hallman, Physics (Haglund) - Electronic interaction of dithiocarbamate ligands with nanorods for hole transport to an attached metal center
Presented by: Andrew La Croix, Chemistry (Macdonald) - Characterization of bonding between superhard ceramics and polymer substrate
Presented by: Ranganathan Parthasarathy, TSU (Ouyang/Lukehart) - pH-Responsive Polymersomes for Immunotherapeutic Targeting of the STING Pathway
Presented by: Daniel Shae, Chemical Engineering (Wilson) - Excipients for the lyoprotection and long term storage of peptide nano-polyplexes
Presented by: Brian Evans, Biomedical Engineering/Vascular Surgery (Duvall) - Dual Drug Delivery: Precise Nanohydrogels Via Liposome Master Templates
Presented by: Jacob Lockhart, Chemistry (Harth) - Photocatalytic Photosystem I/PEDOT Composite Films Prepared by Vapor Phase Polymerization
Presented by: Maxwell Robinson, Chemical Engineering (Jennings) - Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes
Presented by: Kameron Kilchrist, Biomedical Engineering (Duvall) - Probing the Cellular Uptake of DNA Functionalized Gold Nanoparticles with Cell and Lipid Vesicle Models
Presented by: Alexis Wong, Chemistry (Wright) - Scattering Promotes Phonon Transport across the Kink in Boron Carbide Nanowires
Presented by: Qian Zhang, Mechanical Engineering (Li) - Tunable Metasurfaces Based on Vanadium Dioxide
Presented by: Zhihua Zhu, Electrical Engineering (Valentine/Haglund) - Resistance-Temperature Effect of Carbon Black / Polydimethylsiloxane Composite
Presented by: Jing Xu, TSU (Ouyang) - Validation of a Galectin-8 Reporter as a Measure of Nanocarrier Endosomal Escape and Biologic Drug Intracellular Bioavailability
Presented by: Somtochukwu Dimobi, Biomedical Engineering (Duvall) - Phase Coexistence and Strain in a Phase-Change Material Probed via s-SNOM
Presented by: Christina McGahan, Physics and Astronomy (Haglund) - Dual Mode Signal Amplification with Hemin Nanoparticles
Presented by: Lauren Gibson, Chemistry (Wright) - RNAi Nanomedicine Selectively Inhibits Rictor/mTORC2 and Improves Therapeutic Efficacy of Lapatinib In Vivo
Presented by: Thomas Werfel, Biomedical Engineering (Duvall) - Single Quantum Dot Tracking Reveals Statin-Induced Changes in Membrane Dynamics of Serotonin Transporters in Midbrain Neurons
Presented by: Danielle Bailey, Interdisciplinary Materials Science (Rosenthal/Zhang) - Stimulating Pulmonary Immunity via Intranasal Delivery of Nanoparticle Vaccines
Presented by: Frances Knight, Biomedical Engineering (Wilson) - Dual-Mode Crystal-Bound and Surface-Bound Passivation of Quantum Dots
Presented by: Michael Turo, Chemistry (Macdonald) - Band-Edge Exciton Dynamics in Zinc Oxide Nanowires and Nanopopcorn
Presented by: Claire Marvinney, Interdisciplinary Materials Science (Haglund) - Zwitterionic siRNA polyplex coronas improve nanoparticle pharmacokinetics and tumor gene silencing in vivo
Presented by: Meredith Jackson, Biomedical Engineering (Duvall/Giorgio)1st year IGPMS rotation posters submissions
- Capillary filling of carbon nanotubes for next generation batteries
Presented by: Kate Moyer, Interdisciplinary Materials Science (Pint) - Ultrafast Second Harmonic Generation from Vanadium Dioxide Nanostructures
Presented by: Ryan Nolen, Interdisciplinary Materials Science (Haglund)