Selected Publications

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Recent Publications

  1. MAP McGough, SM Shiels, LA Boller, KL Zienkiewicz, CL Duvall, JC Wenke, SA Guelcher. Poly(thioketal urethane) autograft extenders in an intertransverse process model of bone formation. Tissue Eng Part A. 2019 Jan 9. doi: 10.1089/ten.TEA.2018.0223. [Epub ahead of print].
  2. Carlisle, T Guda, DT Silliman, AJ Burdette, AD Talley, R Alvarez, D Tucker, R G Hale, SA Guelcher, P BrownBaer. Localized Low Dose rhBMP-2 is Effective at Promoting Bone Regeneration in a Pre-clinical Mandibular Segmental Defect Model. J Biomed Mater Res Pt. B. 2018 Sep 28. doi: 10.1002/jbm.b.34241. [Epub ahead of print].
  3. S Lu, MAP McGough, SM Shiels, KJ Zienkiewicz, AR Merkel, JP Vanderburgh, JS Nyman, JA Sterling, DJ Tennent, JC Wenke, SA Guelcher. Settable nanocrystalline hydroxyapatite/poly(ester urethane) bone cements provide mechanical stability and remodel in an ovine weight-bearing defect model. Biomaterials 179:29-45, 2018. PMC6065109.
  4. AD Talley, LA Boller, KN Kalpakci, DA Shimko, KJ Zienkiewicz, DL Cochran, SA Guelcher. Injectable, compression-resistant polymer/ceramic composite bone grafts maintain space and promote bone healing without membranes in a canine model of lateral ridge augmentation. Clin Oral Impl Res 29:592–602, 2018. PMC6152823
  5. I Gerges, M Tamplenizza, F Martello, C Recordati, C Martelli, L Ottobrini, M Tamplenizza, SA Guelcher, A Tocchio, C Lenardi. Exploring the Potential of Polyurethane-Based Soft Foam as Cell-Free Scaffolds for Soft Tissue Regeneration. Acta Biomaterialia 73:141-153, 2018.
  6. JP Vanderburgh, SA Guelcher, JA Sterling. 3D Bone Models to Study the Complex Physical and Cellular Interactions Between Tumor and the Bone Microenvironment. Journal of Cellular Biochemistry 119(7):5053-5059, 2018.
  7. JN Lockhart, TJ Spoonmore, MW McCurdy, BR Rogers, SA Guelcher, E Harth. Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth. ACS Appl Mater Interfaces 10(4):4050-4056, 2018. PMC5831121
  8. J Vanderburgh, S Fernando, A Merkel, JA Sterling, SA Guelcher. Fabrication of Trabecular Bone-Templated Tissue-Engineered Constructs by 3D Inkjet Printing. Adv Healthc Mater 6(22), 2017, doi: 10.1002/adhm.201700369. Epub 2017 Sep 11. PMC5815519
  9. P Patil, JR Martin, SM Sarett, AC Pollins, NL Cardwell, JM Davidson, SA Guelcher, LB Nanney, CL Duvall. Porcine Ischemic Wound Healing Model for Preclinical Testing of Degradable Biomaterials. Tissue Eng Pt. C 23(11):754-762, 2017. PMC5689114.
  10. S Shiels, AD Talley, KJ Zienkiewicz, K Kalpakci, D Shimko, SA Guelcher, JC Wenke. Injectable and compression-resistant low-viscosity polymer/ceramic composite carriers for rhBMP-2 in a rabbit model of posterolateral fusion: a pilot study. J Orthop Surg Res 11;12(1):107, 2017. PMC5504717
  11. KA Kwakwa, JP Vanderburgh, SA Guelcher, JA Sterling. Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments. Curr Osteopor Rep 15(4):247-254, 2017.
  12. S Lu, MAP McEnery, BR Rogers, JC Wenke, D Shimko, and SA Guelcher. Resorbable Nanocomposites with Bone-Like Strength and Enhanced Cellular Activity. J Mater Chem B 5:4198 – 4206, 2017. PMC6086367
  13. AD Talley, MAP McEnery, KN Kalpakci, KJ Zienkiewicz, DA Shimko, SA Guelcher. Remodeling of injectable, low-viscosity polymer/ceramic bone grafts in a sheep femoral defect model. Journal of Biomedical Materials Research B: Applied Biomaterials 105(8):2333-2343, 2017.
  14. AD Talley, BR Rogers, V Iakovlev, RF Dunn, SA Guelcher. Oxidation and degradation of polypropylene transvaginal mesh. J Biomater Sci Polym Ed 28(5):444-458, 2017.
  15. J Vanderburgh, JA Sterling, SA Guelcher. 3D printed biomimetic scaffolds for in vitro models of disease progression and drug screening. Ann Biomed Eng. 45(1):164-179, 2017. PMC5106334
  16. VV Iakovlev, SA Guelcher, R Bendavid. In vivo degradation of polypropylene: microscopic analysis of meshes explanted from 130 patients. Journal of Biomedical Materials Research B: Applied Biomaterials 105(2):237-248, 2017.
  17. SA Cannonier, CB Gonzales, K Ely, SA Guelcher, JA Sterling. Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in Oral Squamous Cell Carcinoma. Oncotarget 7(46):76062-76075, 2016. PMC5340177
  18. JR Martin, CE Nelson, MK Gupta, F Yu, KM Hocking, JM Davidson, SA Guelcher, CL Duvall. Local delivery of PHD2 siRNA from ROS-degradable scaffolds to promote diabetic wound healing. Adv Healthc Mater 5(21):2751-2757, 2016. PMC5152672
  19. MAP McEnery, S Lu, MK Gupta, KJ Zienkiewicz, JC Wenke, K Kalpakci, D Shimko, CL Duvall, SA Guelcher. Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength. RSC Advances 6(111):109414 – 109424, 2016. PMC5123593
  20. S Hendrix, TJ Spoonmore, AD Wilde, NE Putnam, ND Hammer, DJ Snyder, SA Guelcher, EP Skaar, JE Cassat. Repurposing the nonsteroidal anti-inflammatory drug diflunisal as an osteoprotective, anti-virulence therapy for Staphylococcus aureus Antimicrob Agents Chemother 60(9):5322-30, 2016. PMC4997817
  21. EJ Adolph, R Guo, JM Davidson, SA Guelcher, LB Nanney. Injected Biodegradable Polyurethane Scaffolds Delay Wound Contraction and Promote Healing of Full-Thickness Excisional Wounds in Pigs. Journal of Biomedical Materials Research B: Applied Biomaterials 104(8):1679-1690, 2016. PMC4837087
  22. PS Thayer, SS Verbridge, LA Dahlgren, S Kakar, SA Guelcher, AS Goldstein. Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells. J Biomed Mater Res A 104(8):1894-901, 2016.
  23. R Guo, AR Merkel, S Lu, JA Sterling, SA Guelcher. Substrate modulus regulates osteogenic differentiation of rat mesenchymal stem cells through integrin B1 and BMP receptor type IA. J Mater Chem B Mater Biol Med. 4(20):3584-3593, 2016. PMC4991780
  24. AD Talley, KN Kalpakci, KJ Zienkiewicz, DL Cochran, SA Guelcher. Effects of rhBMP-2 Dose and Ceramic Composition on New Bone Formation and Space Maintenance in a Canine Mandibular Ridge Saddle Defect Model. Tissue Engineering Part A 22(5-6):469-79, 2016. PMC4800273
  25. EM Prieto, AD Talley, NR Gould, KJ Zienkiewicz, SJ Drapeau, KN Kalpakci, SA Guelcher. Effects of Particle Size and Porosity on In Vivo Remodeling of Settable Allograft Bone/Polymer Composites. Journal of Biomedical Materials Research Part B: Applied Biomaterials 103(8):1641-51, 2015. PMC4496323
  26. R Guo, A Merkel, JA Sterling, JM Davidson, SA Guelcher. Substrate Modulus of 3D-Printed Scaffolds Regulates the Regenerative Response in Subcutaneous Implants through the Macrophage Phenotype and Wnt Signaling. Biomaterials 73:85-95, 2015. PMC4846647
  27. R Guo, S Lu, JM Page, AR Merkel, S Basu, JA Sterling, and SA Guelcher. Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation. Adv Healthc Mater 4(12):1826-32, 2015. PMC4558627
  28. AJ Harmata, S Uppuganti, M Granke, SA Guelcher, JS Nyman. Compressive fatigue and fracture toughness behavior of injectable, settable bone cements. Journal of the Mechanical Behavior of Biomedical Materials 51:345-355, 2015. PMC4581977
  29. RD Cardwell, JA Kluge, PS Thayer, SA Guelcher, LA Dahlgren, DL Kaplan, AS Goldstein. Static and cyclic mechanical loading of mesenchymal stem cells on elastomeric, electrospun polyurethane meshes. J Biomech Eng. 137(7):071010, 2015. PMC4462860
  30. JM Page, AR Merkel, NS Ruppender, UC Dadwal, S Cannonier, R Guo, S Basu, SA Guelcher, JA Sterling. Altering adsorbed proteins or cellular gene expression in bone-metastatic cancer cells affects PTHrP and Gli2 without altering cell growth. Data in Brief 4:440-6, 2015. PMC4534584
  31. JM Page, AR Merkel, NS Ruppender, UC Dadwal, S Cannonier, R Guo, S Basu, SA Guelcher, JA Sterling. Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin beta3 and TGF-beta receptor type II. Biomaterials 64:33-44, 2015. PMC4681301
  32. R Guo, CL Ward, JM Davidson, CL Duvall, JC Wenke, SA Guelcher. A Transient Cell-Shielding Method for Viable MSC Delivery within Hydrophobic Scaffolds Polymerized In Situ. Biomaterials 54:21-33, 2015. PMC440966

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