More circadian rhythms detected by omics approaches
The S2 cell line is a popular Drosophila cell line, which is widely used in the fields of cell biology and biochemistry. By measuring a traditional reporter and canonical clock genes expression, it seemed that this cell line lacked a circadian rhythm. However, when omics approaches were applied, circadian rhythms were detected at all levels from gene expression to the metabolism.
Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes