Recent Publications

Shi SQ, Mahoney CE, Houdek P, Zhao W, Anderson MP, Zhuo X, Beaudet A, Sumova A, Scammell TE, Johnson CH.Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a. Front Behav Neurosci. 2022 Mar 23;16:837523.

Ralph MR, Shi SQ, Johnson CH, Houdek P, Shrestha TC, Crosby P, O’Neill JS, Sládek M, Stinchcombe AR, Sumová A. Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice. PLoS Comput Biol. 2021 17(5):e1008987. PMID: 34048425

Shi SQ, Johnson CH. Circadian biology and sleep in monogenic neurological disorders and its potential application in drug discovery. Current Opinion in Behavioral Sciences. 2019 25: 23-30. In this review article, we summarized circadian and sleep phenotypes in monogenic neurological disorders including Angelman, Huntington, Fragile X, and Rett syndromes. In addition, we discussed possible genotype-phenotype interactions of the biological clock in those diseases.

Shi SQ*, White MJ*, Borsetti HM*, Pendergast JS, Hida A, Ciarleglio CM, de Verteuil PA, Cadar AG, Cala C, McMahon DG, Shelton RC, Williams SM, Johnson CH. Molecular Analyses of Circadian Gene Variants Reveal Sex-dependent Links Between Depression and Clocks. Translational Psychiatry. 2016 Mar 1;6: e748 *equal contribution. PMID: 26926884 In this paper, combining medical record and big data analysis of genomics in Major Depressive Disorder (MDD), we explored possible functions of  SNPs of circadian genes in MDD. 

Shi SQ, Bichell TJ, Ihrie R, Johnson CH. Ube3A Imprinting Impairs Circadian Robustness in Angelman Syndrome Models. Current Biology. 2015 25(5):537-45. PMID: 25660546

Shi SQ, Ansari T, Wasserman DH, McGuinness OP, Johnson CH. Circadian Disruption Leads to Insulin Resistance and Obesity. Current Biology. 2013 23(5):372-381. PMID: 23434278.

Shi SQ, Hida A, McGuinness OP, Wasserman DH, Yamazaki S, Johnson CH. Circadian Clock Gene Bmal1 Is Not Essential; Functional Replacement with its Paralog, Bmal2. Current Biology. 2010 20(4):316-21. PMID: 20153195.

Yang J , Cumberbatch D, Centanni S , Shi SQ, Winder D , Webb D, Johnson CH Coupling Optogenetic Stimulation with NanoLuc-based Luminescence (BRET) Ca++ Sensing. Nature Communications 2016 Oct 27; 7:13268 PMID: 27786307.