Home » PrePub Compounds » LH1299

LH1299

 

M Wt. 266
Formula: C16 H14 N2 S
Smiles:

Phenotype

Descriptor

Anatomical Features AR1299

AxisReduced length
BloodPresent
Blood circulationAbsent, pooling
BrainAbnormal
CloacaAbsent
EyeReduced size
Eye pigmentationReduced amount
ForebrainReduced size
Fourth ventricleNormal
HeadReduced size
HeartAbnormal, reduced size
Heart contractionAbnormal
LocomotionReduced amount
MelanocyteReduced amount
Midbrain hindbrain boundaryPresent
NotochordReduced width, reduced length
Otic placodeReduced size
OtolithNormal
PericardiumSwollen
Post-vent regionAbsent
SomiteAbnormal
Third VentricleReduced size
TrunkReduced length
TailAbsent
Whole organismReduced length
YolkIncreased size

Cheminformatics

Molinspiration

Bioactivity score v2016.03
GPCR ligand                     -0.14
Ion channel modulator      -0.06
Kinase inhibitor                  0.11
Nuclear receptor ligand    -0.22
Protease inhibitor             -0.31
Enzyme inhibitor               0.05

ChemProt TC>0.97

N/A

Lasso

Category Target PDB Code LASSO Score
Kinases P38 MAP, P38 mitogen activated protein 1kv2 0.94
Kinases VEGFr2, vascular endothelial growth factor receptor 1vr2 0.85
Kinases PDGFrb, platelet derived growth factor receptor kinase N/A 0.71

Confirmed Pathway Activity

Synergist

Wnt signaling (EC2X): Does not potentiate

Confirmed Targets


Recent Comments

Archives

Categories

Meta