Home » PrePub Compounds » BAI8462

BAI8462

 

 

M Wt. 287
Formula: C15H17N3OS
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Phenotype

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Descriptor

Anatomical Features BAI8462

AxisReduced length, Curved ventrally
BloodAbsent
Blood circulationAbsent
BrainNormal
CloacaAbsent
EyeNormal
Eye pigmentationAbsent
ForebrainReduced size
Fourth ventricleReduced size
HeadReduced size
HeartReduced size
Heart contractionAbnormal, bradycardia
LocomotionMovement-loss
MelanocyteAbsent
Midbrain hindbrain boundaryPresent
NotochordReduced length
Otic placodeReduced size
OtolithNormal
PericardiumSwollen
Post-vent regionReduced size
SomiteAbnormal
Third VentricleNormal
TrunkNormal
TailReduced length
Whole organismAbnormal color, reduced length
YolkIncreased size

Cheminformatics

Molinspiration

GPCR ligand                   -0.37
Ion channel modulator    -0.83
Kinase inhibitor               -0.47
Nuclear receptor ligand  -1.13
Protease inhibitor            -0.68
Enzyme inhibitor             -0.24

ChemProt TC>0.95

SMAD 3 =0.56

Lasso

Category Target PDB ID Score
Metalloenzymes ACE, angiotensin-converting enzyme 1o86 0.03
Nuclear Hormone Receptors PPARg, peroxisome proliferator activated receptor 1fm9 0.03
Serine Proteases FXa, factor Xa 1f0r 0.02

 Confirmed Pathway

 

Confirmed Target


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