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Publications
2017
- Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay and drug development technologies. 2017 Apr 5.
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Sheng C, Amiri-Kordestani L, Force T, Hong C, Wu C, Croce K, Kim G, Moslehi J. 21st Century Cardio-Oncology: Identifying Cardiac Safety Signals in the Era of Personalized Medicine Journal of American College of Cardiology: Basic to Translational Science. in press(2017).
2016
- Jiramongkolchai P, Owens P, Hong CC. Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition. Biochemical Society transactions. 2016 Aug 15;44(4). 1117-34.
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Hover LD, Owens P, Munden AL, Wang J, Chambless LB, Hopkins CR, Hong CC, Moses HL, Abel TW. Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma. Neuro-oncology. 2016 Jul;7(18). 928-938.
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Clark CR, Robinson JY, Sanchez NS, Townsend TA, Arrieta JA, Merryman WD, Trykall DZ, Olivey HE, Hong CC, Barnett JV. Common pathways regulate type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells. Cellular signalling. 2016 Mar 9.
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Hempel JE, Cadar AG, Hong CC. Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action. Bioorganic & medicinal chemistry letters. 2016 Mar 7.
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Tadokoro T, Gao X, Hong CC, Hotten D, Hogan BL. BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. Development (Cambridge, England). 2016 Jan 25.
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Williams CH, Hong CC. Zebrafish small molecule screens: Taking the phenotypic plunge. Computational and structural biotechnology journal. 14. 350-356.
2015
- Hover LD, Young CD, Bhola NE, Wilson AJ, Khabele D, Hong CC, Moses HL, Owens P. Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Cancer letters. 2015 Jul 30.
- Habib A, Polavarapu R, Karmali V, Guo L, Van Dam R, Cheng Q, Akahori H, Saeed O, Nakano M, Pachura K, Hong CC, Shin E, Kolodgie F, Virmani R, Finn AV. Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques. Atherosclerosis. 2015 Jun 19;241(2). 692-700.
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Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong* CC, Moses* HL. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene. *Co-senior authors; 2015 May 7;34(19). 2437-49.
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Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell reports. 2015 Apr 7;11(1). 43-50. NIHMSID: NIHMS669677.
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Williams H, Hong C. High content screening for modulators of cardiovascular or global developmental pathways in zebrafish. In: Chemical Biology: Methods and Protocols. Springer Press; 1263. 167-174.
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Hempel E, Hong C. Practical Strategies for Small Molecule Probe Development in Chemical Biology. In: Chemical Biology: Methods and Protocols. Springer Press; 1263. 209-223.
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Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC, Paria BC, Denton JS, Reese J. High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility. PloS one. 10(11). e0143243.
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Hempel JE, Williams CH, Hong CC. Preface. Chemical biology. Methods in molecular biology (Clifton, N.J.). 1263. v.
2014
- Fotinos A, Nagarajan N, Martins AS, Fritz DT, Garsetti D, Lee AT, Hong CC, Rogers MB. Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cells. Anticancer research. 2014 May;34(5). 2095-104.
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Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K. BMP pathway regulation of and by macrophages. PloS one. 9(4). e94119.
2013
- Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell reports. 2013 Sep 12;4(5). 898-904. NIHMSID: NIHMS514783.
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Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL. A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 2013 Jul;28(7). 1733-43.
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Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorganic & medicinal chemistry letters. 2013 Jun 1;23(11). 3248-52. NIHMSID: NIHMS466834.
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Engers W, Frist Y, Lindsley W, Hong C, Hopkins R. Development of a potent and ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor. Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information; 2013 Apr 12.
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Shelton EL, Galindo CL, Williams CH, Pfaltzgraff E, Hong CC, Bader DM. Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia. PloS one. 8(7). e69712.
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Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC, Moses HL. Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PloS one. 8(6). e67533.
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Langenfeld E, Hong CC, Lanke G, Langenfeld J. Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines. PloS one. 8(4). e61256.
2012
- Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS chemical neuroscience. 2012 Jun 20;3(6). 482-91.
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Saeed O, Otsuka F, Polavarapu R, Karmali V, Weiss D, Davis T, Rostad B, Pachura K, Adams L, Elliott J, Taylor WR, Narula J, Kolodgie F, Virmani R, Hong CC, Finn AV. Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2012 Feb;32(2). 299-307. NIHMSID: NIHMS343415.
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Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ. The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflammatory bowel diseases. 2012 Jan;18(1). 112-9. NIHMSID: NIHMS265539.
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Ao A, Hao J, Hopkins CR, Hong CC. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. PloS one. 7(7). e41627.
2011
- Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood. 2011 Nov 3;118(18). 4977-84.
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Cross EE, Thomason RT, Martinez M, Hopkins CR, Hong* CC, Bader* DM. Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors. ACS chemical biology. *Co-corresponding authors; 2011 Sep 16;6(9). 952-61. NIHMSID: NIHMS312854.
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Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood. 2011 Jul 21;118(3). 747-56. PMCID: PMC3142910.
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Ao A, Hao J, Hong CC. Regenerative chemical biology: current challenges and future potential. Chemistry & biology. 2011 Apr 22;18(4). 413-24. NIHMSID: NIHMS285706.
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Shi S, Hoogaars WM, De Gorter DJ, Van Heiningen SH, Lin HY, Hong CC, Kemaladewi DU, Aartsma-Rus A, Ten Dijke P, ‘t Hoen PA. BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model. Neurobiology of disease. 2011 Feb;41(2). 353-60. NIHMSID: NIHMS467999.
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Williams CH, Hong CC. Multi-step usage of in vivo models during rational drug design and discovery. International journal of molecular sciences. 12(4). 2262-74.
2010
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Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS chemical biology. 2010 Feb 19;5(2). 245-53. NIHMSID: NIHMS169068.
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Hao J, Williams CH, Webb ME, Hong CC. Large scale zebrafish-based in vivo small molecule screen. Journal of visualized experiments : JoVE.
2009
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Hong CC, Yu PB. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine & growth factor reviews. 20(5-6). 409-18. NIHMSID: NIHMS154872.
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Hong CC. Large-scale small-molecule screen using zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 486. 43-55.
2008
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Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nature medicine. 2008 Dec;14(12). 1363-9. NIHMSID: NIHMS187710.
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Hong CC, Kume T, Peterson RT. Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circulation research. 2008 Sep 12;103(6). 573-9. NIHMSID: NIHMS126759.
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Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KD. Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. The Journal of biological chemistry. 2008 Feb 15;283(7). 3877-88.
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Hao J, Daleo MA, Murphy CK, Yu PB, Ho JN, Hu J, Peterson RT, Hatzopoulos AK, Hong CC. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PloS one. 3(8). e2904.
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Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology. 2008 Jan;4(1). 33-41. NIHMSID: NIHMS44146.
