M.Wt: 399.5
Formula: C₂₄H₂₅N₅O
Smiles: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

Phenotype

 

 

SwissADME

 

 

Confirmed Pathway Activity

Antagonist

BMP signaling (IC50): 0.47 uM

Confirmed Targets

ALK2 (IC₅₀ = 0.15 uM)

KDR (IC₅₀ = 0.03 uM)

AMPK (IC₅₀ = 0.23 uM)

 

Additional Information

Publications

Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.Nat Chem Biol. 2008 Jan;4(1). 33-41.

Citations: 753 (May 2017)

Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS chemical biology. 2010 Feb 19;5(2). 245-53.

Citations: 194 (May 2017)

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