Greenplate AR, Johnson DB, Roussel M, Savona MR, Sosman JA, Puzanov I, Ferrell PB*, Irish JM*. Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti–PD-1 Therapy, Cancer Immunology Research 2016. PMC4891280. Pubmed. DOI. *Co-corresponding.
► This peer-reviewed research study describes a case report where systems immune monitoring with mass cytometry revealed unexpected emergence of malignant myelodysplastic syndrome (MDS) blast cells in the blood of a melanoma patient. The multidimensional mass cytometry panel enabled the blasts to be characterized in detail without analysis of a new sample by mining the existing data.