Doxie DB, Greenplate AR, Gandelman JS, Diggins KE, Roe CE, Dahlman KB, Sosman JA, Kelley MC, Irish JM. BRAF and MEK inhibitor therapy eliminates nestin expressing melanoma cells in human tumors. Pigment Cell & Melanoma Research 2018 May 19. PMCID in progress. Pubmed. DOI.
► This peer-reviewed research revealed dramatic changes in the cellular composition of melanoma tumors that occur in vivo in patients treated with BRAF and MEK inhibitors and revealed a new, clinically-relevant melanoma cell type. This study was the first to apply mass cytometry to serial samples of the same solid tumor over time during treatment. This work resulted from a collaboration between surgeon Mark Kelley and the Irish lab that was led by graduate student Deon Doxie and followed Deon’s award-winning co-first author methods manuscript in Cytometry B.