Janos L. Mathe

Immunization Content Management

Edited on 2018-08-22

Project Summary

Immunizations are one of the most cost-effective interventions for preventing morbidity and mortality. As vaccines, related clinical knowledge and requirements change, clinical applications must be updated in a timely manner to avoid practicing outdated medicine.

We use the Centers for Disease Control and Prevention (CDC) as a source for immunization knowledge for our Clinical Information Systems (CIS). After identifying knowledge management related gaps in the CDC’s content and email notification service, we utilized our knowledge management tool chain – called COMET – for facilitating automatic processing of the available immunization content to implement mature knowledge life-cycle management practices locally.

The implemented features include error and change tracking, content discovery and analytics, and tracking of dependencies to dependent downstream CISs. We demonstrate the creation of a tool that enables content curators to visualize, track, and implement immunization changes.

Example content query visualized via OrientDB’s graph editor

Example immunization content query visualized via OrientDB’s graph editor

Contribution

  • Domain analysis, documentation
  • Solution architecture design
  • Domain model development
  • ETL implementation to OrientDB graph database
  • Timeline visualization tool implementation to show the evolution of the ETL execution results
  • Design and implementation of a multi-dimensional versioning method for asset change tracking

Publications

Mathe, J.L.; Nelson, S.D.; Weinberg, S.T.; Lehmann, C.U.; Nadas, A.; Weitkamp, A.O. Leveraging Knowledge Representation to Maintain Immunization Clinical Decision Support, in: Proceedings of the AMIA Annual Symposium. Presented at the American Medical Informatics Association Annual Symposium Proceedings (AMIA Symposium), San Francisco, CA 2018.

Wen, H.; Mathe, J.L.; Weinberg, S.T.; Weitkamp, A.O.; Nelson, S.D. A single source of truth for knowledge management of immunization content. American Journal of Health-System Pharmacy (AJHP): Official Journal of the American Society of Health-System Pharmacists, Residents Edition 2018.

Mathe, J.L. Practical Knowledge Engineering for Clinical Decision Support. Presented at the Biomedical Informatics Seminar, Vanderbilt University 2018.

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Contact Information

e | janos.l.mathe@vumc.org
p | +1 (615) 875-8778
a | Rm 515B, Ste 500, Bld 3401WE