Membrane Scaffolding


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Speaker Schedule

8th International Meeting on Tetraspanins & Membrane Scaffolds
June 17-20, 2015
Vanderbilt University, Nashville, TN

Jennifer Gillette (University of New Mexico HSC), Andries Zijlstra (Vanderbilt University),
Xin Zhang (University of Oklahoma HSC), Shoshana Levy (Stanford University)

Wednesday, June 17th
2:00 – 9:00 pm            Registration
5:30 – 6:30 pm            Dinner at “The Commons”
7:00 pm                       Welcome Reception at “Stambaugh House” on the Peabody Campus

Thursday, June 18th
7:30 – 8:30 am            Breakfast at “The Commons”

8:45 am – 11:40 pm Membrane Scaffolds & Host Pathogens
Discussion Leader:  Annemiek van Spriel Light Hall room 214

8:45 – 9:15 am
María Yáñez-Mó, Servicio de Immunologia, Hospital de la Princesa,
Hospital Santa Critina, Instituto de Investigación Sanitaria La Princesa, Madrid, Spain
“CD81 modulates HIV-1 reverse transcription by controlling SAMHD1 activity”

9:15 – 9:35 am
Daniel Hochdorfer*, Institute of Virology University Medical Center, Ulm, Germany
“Tetraspanin CD151 promotes initial events of human cytomegalovirus infection”
*NIH R13 Travel Award Recipient

9:35 – 10:05 am
Jenny Tam, Departments of Medicine, Infectious Disease
Massachusetts General Hospital, Boston, USA
“Tetraspanin CD82 regulates Candida albicans induced LC3-associated phagocytosis (LAP) in macrophages”

10:05 – 10:25 am Coffee Break/Discussion Time

10:25 – 10:55 am
Markus Thali, Department of Microbiology & Molecular Genetics, College of Medicine and CALS, University of Vermont, USA
“Fusion regulation at the virological presynapse”

10:55 – 11:15 am
Jenny Ventress, Department of Infection and Immunity,
University of Sheffield Medical School, UK
“Development of tetraspanin-based therapies for Staphylococcus aureus infection”

11:15 – 11:45 am
Thomas Gallagher, Department of Microbiology and Immunology,
Loyola University Medical Center,
“Roles for transmembrane proteases and tetraspanin-enriched microdomains in enveloped virus entry”

12:00 – 1:00pm Lunch at “The Commons”


1:30 – 5:10 pm Membrane Scaffolds & Development
Discussion Leader:  Chris Stipp Light Hall room 214

1:30 – 2:10 pm
Eric Rubinstein, Inserm, U935, Institut André Lwoff, Université Paris-Sud, Villejuif, France
“TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization”

2:10 – 2:30 pm
Isabel Salas*, VIB Center for Biology of Disease & Center of Human Genetics and Leuven Institute for Neurodegenerative Diseases, KULeuven, Leuven, Gasthuisberg O&N, Belgium
“Role of Tspan6 in synaptic function”
*NIH R13 Travel Award Recipient

2:30 – 3:00 pm
Harald Junge, Department of Molecular, Cellular, & Developmental Biology, University of Colorado, Boulder, CO, USA
“TSPAN12 in beta-catenin signaling and retinal angiogenesis”

3:00 – 3:40 pm Coffee Break/Discussion Time Light Hall Lobby

3:40 – 4:10 am
Michael Tomlinson, School of Biosciences, University of Birmingham, Birmingham, UK
“Tspan9 and Tspan18 are required for normal platelet function”

4:10 – 4:40 am
Cindy Miranti, Laboratory of Integrin Signaling and Tumorigenesis, Van Andel Institute, Grand Rapids, MI, USA
“Defective Osteoclasts in CD82 Null Mice”

4:40 – 5:10 pm
Xin Zhang, Department of Physiology and Stephenson Cancer Center University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
“CD82 and Vascular Permeability”

5:30 – 6:30 pm            Dinner at “The Commons” on the Peabody Campus

7:00 – 9:00 pm            Posters and Social Hour in “Stambaugh House”


Friday, June 19th

7:30 – 8:30 am            Breakfast at “The Commons”

8:45 am – 12:30 pm
Membrane Scaffolds & Cancer
Discussion Leader:  Xin Zhang Note Change in location: Light Hall room 202

8:45 – 9:25 am
Martin Hemler, Dana-Farber Cancer Institute, Harvard University, Boston, MA, USA
“New insights into CD151 contributions to anti-cancer drug resistance”

9:25 – 9:45 am
Charlotte Maria (Lotte) de Winde*, Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
“Protection against development of B cell lymphoma by CD37”
*NIH R13 Travel Award Recipient

9:45 – 10:10 pm Coffee Break/Discussion Time

Note Change in location: Light Hall room 214

10:10 – 10:40 am
Chris Stipp
, Department of Biology and Department of Molecular Physiology & Biophysics, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA
“CD151 Promotes a3b1 Integrin-Dependent Organization of Carcinoma Cell Junctions and Restrains Collective Cell Invasion”

10:40 – 11:00 am
Mauricio Medrano*, Princess Margaret Cancer Center, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Canada
“Interrogation of functional cell surface markers identifies CD151 dependency in serous ovarian cancer”
*Company of Biologists Conference Grant Travel Award Recipient

11:00 – 11:20 am
Jasmeet Reyat*, School of Biosciences, College of Life and Environmental Sciences & School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
“ADAM10-dependent shedding of vascular endothelial (VE)-cadherin regulates lymphocyte transmigration in vitro”

11:20 – 11:40 am
Christina Termini*, Ph.D. Student, Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
“CD82 regulates the spatial organization of the α4 integrin and the temporal dynamics PKCα signaling”
*New Mexico Spatial & Temporal Modeling Center Travel Award Recipient

11:40 – 12:30 pm        Business meeting

12:30 – 1:30 pm          Lunch at “The Commons” on Peabody Campus

2:00 – 3:30 pm Tetraspanins & Translational Science
Discussion Leader:  Jennifer Gillette Light Hall room 214

2:00 – 2:30 pm
Natarajan Muthusamy, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
“Beyond Scaffolding-Tetraspanins as therapeutic targets in Leukemia”

2:30 – 3:00 pm Shanna Arnold, Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA

“Analysis of shed ALCAM, a tetraspanin-associated cell adhesion molecule, as a prognostic marker in renal cancer”

3:00 – 3:30 pm
Peter Monk, Departments of Infection and Immunity and Molecular Biology and Biotechnology, The University of Sheffield, UK.
“Tetraspanins and pathogenic bacteria: ‘we shall fight on the landing grounds”

3:30 pm Group Photo Outside of Light Hall

3:50 – 4:20 pm Coffee Break/Discussion Time Light Hall Lobby

4:20 – 6:00 pm Membrane Scaffolds & Exosomes
Discussion Leader:  Shoshana Levy Light Hall room 214

4:20 – 4:50 pm
Bob Coffey, Ingram Professor of Cancer Research Vanderbilt University, Nashville, TN, USA
“A New Mode of EGF Receptor Signaling via Exosomes”

4:50 – 5:10 pm              Lian Willets*, Department of Oncology University of Alberta, Edmonton, AB, Canada.
“Development of an extracellular vesicle micro-flow cytometry assay for prostate cancer prognosis”

*Company of Biologists Conference Grant Travel Award Recipient

5:10 – 5:30 pm
Bong Hwan Sung, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA
“Directional cancer cell migration through tissues is regulated by exosome secretion”

5:30 – 6:00 pm
Margot Zoller, Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
“Approaching the functionality of CIC markers in pancreatic and colorectal cancer via exosomes”

7:00pm                        Dinner & Musical Entertainment at “The Coffee Shop” on Music Row

9:00 pm                       Music & Downtown Nashville Experience


Saturday, June 20th
7:30 – 8:30 am            Breakfast at “Light Hall” Light Hall Lobby

9:00 – 12:30 pm Membrane Scaffolds & Immunity
Discussion Leader:  Peter Monk Light Hall room 214

9:00 – 9:40 am
Annemiek Van Spriel, Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
“The tetraspanin web revisited by super-resolution microscopy”

9:40 – 10:10 am
Siew Cheng Wong, Singapore Immunology Network (SIgN), ASTAR, Singapore
“Involvement of tetraspanins in multinucleated giant cells formation by human blood monocyte subsets”

10:10 – 10:40 am
Shoshanna Levy, Department of Medicine, Division of Oncology, Stanford University, Medical Center, Stanford, CA, USA
“Tumor growth and metastasis is reduced in CD81-deficient mice – role of the immune system”

10:40 – 11:10 am Coffee Break/Discussion Time

11:20 – 11:30 am        Intro to European Meeting:  Peter Monk

11:30 – 12:00 pm
Mark Wright, Department of Immunology, Monash University, Melbourne, VIC, Australia
“Tetraspanins are key components of the leucocyte adhesion cascade”

12:00 – 12:20 pm
Jennifer Gillette, Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
“Regulation of hematopoietic stem cell fitness by the tetraspanin CD82”

12:30 pm Farewell / Box Lunch To Go


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