Publications

Representative recent publications are shown below.

A more complete list (about 200 lab publications) is available at the following site:  https://wag.app.vanderbilt.edu/PublicPage/Faculty/Details/29538

Westland MD, Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA, McClain MS, Cover TL. Taurine modulates host cell responses to Helicobacter pylori VacA toxin. Infect Immun [print-electronic]. 2024 Jul 7/8/2024; e0022424. PMID: 38975764, DOI: 10.1128/iai.00224-24, ISSN: 1098-5522.

Connolly SM, Erwin AL, Sabb M, Hanks JL, Chang L, Torrez RM, Caso GC, Campbell AM, Mosalaganti S, Cover TL, Ohi MD. Structural Analysis of Membrane-associated Forms of Helicobacter pylori VacA Toxin. Journal of Molecular Biology. 2024 Feb 15;436(4):168432.

Shuman JH, Lin AS, Westland MD, Bryant KN, Piazuelo MB, Reyzer ML, Judd AM, McDonald WH, McClain MS, Schey KL, Algood HM. Remodeling of the gastric environment in Helicobacter pylori-induced atrophic gastritis. mSystems. 2024 Jan 23;9(1):e01098-23.

Tran SC, McClain MS, Cover TL. Role of the CagY antenna projection in Helicobacter pylori Cag type IV secretion system activity. Infection and Immunity. 2023 Sep 14;91(9):e00150-23.

Raspe J, Schmitz MS, Barbet K, Caso GC, Cover TL, Müller A, Taube C, Reuter S. Therapeutic properties of Helicobacter pylori-derived vacuolating cytotoxin A in an animal model of chronic allergic airway disease. Respiratory Research. 2023 Jul 6;24(1):178.

McClain MS, Bryant KN, McDonald WH, Algood HM, Cover TL. Identification of an Essential LolD-Like Protein in Helicobacter pylori. Journal of Bacteriology. 2023 Apr 25;205(4):e00052-23.

Loh JT, Struttmann EL, Favret N, Harvey ML, Pakala SB, Chopra A, McClain MS, Cover TL. A Positively Selected fur-R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression. Infection and Immunity. 2023 Feb 16;91(2):e00420-22.

Allen MG, Bate MY, Tramonte LM, Avalos EY, Loh J, Cover TL, Forsyth MH. Regulation of Helicobacter pylori Urease and Acetone Carboxylase Genes by Nitric Oxide and the CrdRS Two-Component System. Microbiology Spectrum. 2023 Feb 14;11(1):e04633-22.

Reuter S, Raspe J, Uebner H, Contoyannis A, Pastille E, Westendorf AM, Caso GC, Cover TL, Müller A, Taube C. Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease. Frontiers in Immunology. 2023 Jan 24;14:1092801.

Sheedlo MJ, Ohi MD, Lacy DB, Cover TL. Molecular architecture of bacterial type IV secretion systems. PLoS Pathog. 2022 Aug 11;18(8):e1010720.

Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK. An infection-induced oxidation site regulates legumain processing and tumor growth. Nat Chem Biol. 2022 Jul;18(7):698-705.

Loh JT, Shuman JHB, Lin AS, Favret N, Piazuelo MB, Mallal S, Chopra A, McClain MS, Cover TL. Positive Selection of Mutations in the Helicobacter pylori katA 5′ Untranslated Region in a Mongolian Gerbil Model of Gastric Disease. Infect Immun. 2022 Jun 2:e0000422.

Lin AS, Shuman JHB, Kotnala A, Shaw JA, Beckett AC, Harvey JL, Tuck M, Dixon BREA, Reyzer ML, Algood HMS, Schey KL, Piazuelo MB, Cover TL. Loss of Corpus-Specific Lipids in Helicobacter pylori-Induced Atrophic Gastritis.  mSphere. 2021 Dec 22;6(6):e0082621. 

Caso GC, McClain MS, Erwin AL, Truelock MD, Campbell AM, Leasure CS, Nagel M, Schey KL, Lacy DB, Ohi MD, Cover TL. Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin.  Infect Immun. 2021 Nov 16;89(12):e0034821.

Harvey ML, Lin AS, Sun L, Koyama T, Shuman JHB, Loh JT, Algood HMS, Scholz MB, McClain MS, Cover TL.  Enhanced Fitness of a Helicobacter pylori babA Mutant in a Murine Model.  Infect Immun. 2021 Sep 16;89(10):e0072520.

Cover TL. Tracking bacterial effector protein delivery into host cells.  Mol Microbiol. 2021 Sep;116(3):724-728.

Loh JT, Shum MV, Jossart SDR, Campbell AM, Sawhney N, McDonald WH, Scholz MB, McClain MS, Forsyth MH, Cover TL.  Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System.  Infect Immun 2021 Mar 17;89(4):e00597-20.

Dooyema SDR, Krishna US, Loh JT, Suarez G, Cover TL, Peek RM. Helicobacter pylori-Induced TLR9 Activation and Injury Are Associated With the Virulence-Associated Adhesin HopQ.  J Infect Dis. 2021 Jul 15;224(2):360-365.

Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, Sah R, Cover TL, Chou J, Geha R, Benavides F, Hume RI, Xu H.  LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. Proc Natl Acad Sci USA 2020 Nov 17;117(46):29155-29165.

Sheedlo MJ, Chung JM, Sawhney N, Durie CL, Cover TL, Ohi MD, Lacy DB.  Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex. Elife 2020 Sep 2;9:e59495.

Cover TL, Lacy DB, Ohi MD.  The Helicobacter pylori Cag Type IV Secretion System. Trends Microbiol. 2020 Aug;28(8):682-695. 

Lin AS, McClain MS, Beckett AC, Caston RR, Harvey ML, Dixon BREA, Campbell AM, Shuman JHB, Sawhney N, Delgado AG, Loh JT, Piazuelo MB, Algood HMS, Cover TL. Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis. mBio. 2020 Jun 30;11(3):e01296-20.

McClain MS, Voss BJ, Cover TL. Lipoprotein Processing and Sorting in Helicobacter pylori. mBio. 2020 May 19;11(3):e00911-20.  

Caston RR, Sierra JC, Foegeding NJ, Truelock MD, Campbell AM, Frick-Cheng AE, Bimczok D, Wilson KT, McClain MS, Cover TL.  Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants. Infect Immun. 2020 May 20;88(6):e00032-20.

Lin AS, Dooyema SDR, Frick-Cheng AE, Harvey ML, Suarez G, Loh JT, McDonald WH, McClain MS, Peek RM Jr, Cover TL. Bacterial Energetic Requirements for Helicobacter pylori Cag Type IV Secretion System-Dependent Alterations in Gastric Epithelial Cells. Infect Immun. 2020 Jan 22;88(2):e00790-19.

Varga MG, Butt J, Blot WJ, Le Marchand L, Haiman CA, Chen Y, Wassertheil-Smoller S, Tinker LF, Peek RM Jr, Potter JD, Cover TL, Hyslop T, Zeleniuch-Jacquotte A, Berndt SI, Hildesheim A, Waterboer T, Pawlita M, Epplein M. Racial Differences in Helicobacter pylori CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States. Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):2084-2092. 

Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD.  Structure of the Helicobacter pylori Cag Type IV secretion system.   Elife. 2019 Jun 18;8. pii: e47644.

Hu B, Khara P, Song L, Lin AS, Frick-Cheng AE, Harvey ML, Cover TL, Christie PJ.  In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System. MBio. 2019 May 14;10(3). pii: e00849-19.

Caston RR, Loh JT, Voss BJ, McDonald WH, Scholz MB, McClain MS, Cover TL. Effect of environmental salt concentration on the Helicobacter pylori exoproteome. J Proteomics. 2019 May 4;202:103374.

Su M, Erwin AL, Campbell AM, Pyburn TM, Salay LE, Hanks JL, Lacy DB, Akey DL, Cover TL, Ohi MD. Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization. J Mol Biol. 2019 May 3;431(10):1956-1965.

Foegeding NJ, Raghunathan K, Campbell AM, Kim SW, Lau KS, Kenworthy AK, Cover TL, Ohi MD. Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability. Infect Immun. 2019 Apr; 87(4): PII: IAI.00783-18.

Altobelli A, Bauer M, Velez K, Cover TL, Müller A. Helicobacter pylori VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection. MBio. 2019 Mar; 10(2): PII: mBio.00261-19.

Loh JT, Lin AS, Beckett AC, McClain MS, Cover TL. Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability. Infect Immun. 2019 Feb; 87(2): PII: IAI.00692-18.

Noto JM, Rose KL, Hachey AJ, Delgado AG, Romero-Gallo J, Wroblewski LE, Schneider BG, Shah SC, Cover TL, Wilson KT, Israel DA, Roa JC, Schey KL, Zavros Y, Piazuelo MB, Peek RM Jr.  Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression. Mol Cell Proteomics. 2019 Feb;18(2):352-371.

Kyburz A, Fallegger A, Zhang X, Altobelli A, Artola-Boran M, Borbet T, Urban S, Paul P, Münz C, Floess S, Huehn J, Cover TL, Blaser MJ, Taube C, Müller A.  Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells.  J Allergy Clin Immunol. 2019 Apr;143(4):1496-1512.

Butt J, Varga MG, Blot WJ, Teras L, Visvanathan K, Le Marchand L, Haiman C, Chen Y, Bao Y, Sesso HD, Wassertheil-Smoller S, Ho GYF, Tinker LE, Peek RM, Potter JD, Cover TL, Hendrix LH, Huang LC, Hyslop T, Um C, Grodstein F, Song M, Zeleniuch-Jacquotte A, Berndt S, Hildesheim A, Waterboer T, Pawlita M, Epplein M.  Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States. Gastroenterology. 2019 Jan;156(1):175-186

Raghunathan K, Foegeding NJ, Campbell AM, Cover TL, Ohi MD, Kenworthy AK. Determinants of raft partitioning of the Helicobacter pylori pore-forming toxin VacA. Infect Immun. 2018 Apr 23;86(5). pii: e00872-17.

Loh JT, Beckett AC, Scholz MB, Cover TL. High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins. Infect Immun. 2018 Feb 20;86(3). pii: e00626-17.

Beckett AC, Loh JT, Chopra A, Leary S, Lin AS, McDonnell WJ, Dixon BREA, Noto JM, Israel DA, Peek RM Jr, Mallal S, Algood HMS, Cover TL.  Helicobacter pylori genetic diversification in the Mongolian gerbil model. PeerJ. 2018 May 18;6:e4803.

Noto JM, Chopra A, Loh JT, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett AC, Wilson KT, Cover TL, Mallal S, Israel DA, Peek RM.  Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments. Gut. 2018 Oct;67(10):1793-1804.

McClain MS, Beckett AC, Cover TL. Helicobacter pylori Vacuolating Toxin and Gastric Cancer. Toxins (Basel). 2017 Oct 12;9(10). pii: E316.

Kyburz A, Urban S, Altobelli A, Floess S, Huehn J, Cover TL, Müller A. Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy. Clin Exp Allergy. 2017 Oct;47(10):1331-1341.

Bullock KK, Shaffer CL, Brooks AW, Secka O, Forsyth MH, McClain MS, Cover TL. Genetic signatures for Helicobacter pylori strains of West African origin. PLoS One. 2017 Nov 29;12(11):e0188804.

Frick-Cheng AE, Pyburn TM, Voss BJ, McDonald WH, Ohi MD, Cover TL. Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex. MBio. 2016 Jan 12;7(1):e02001-15.

Cover TL. Helicobacter pylori Diversity and Gastric Cancer Risk. MBio. 2016 Jan 26;7(1):e01869-15.

Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M. Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens.  MBio. 2016 Apr 26;7(2):e00221-16.

Beckett AC, Piazuelo MB, Noto JM, Peek RM, Washington MK, Algood HM, Cover TL. Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration. Infect Immun 2016 Dec; 84(12): 3338-49.

Pyburn TM, Foegeding NJ, González-Rivera C, McDonald NA, Gould KL, Cover TL, Ohi MD. Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin. Mol Microbiol. 2016 Oct;102(1):22-36.

Snider CA, Voss BJ, McDonald WH, Cover TL. Growth phase-dependent composition of the Helicobacter pylori exoproteome. J Proteomics. 2016 Jan; 130: 94-107.

González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL. A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain. Infect Immun. 2016 Sep; 84(9): 2662-70.

Schmitz JE, Taniguchi T, Misawa N, Cover TL. Epithelial Coculture and l-Lactate Promote Growth of Helicobacter cinaedi under H2-Free Aerobic Conditions. Appl Environ Microbiol. 2016 Oct 27;82(22):6701-6714.

Loh JT, Gaddy JA, Algood HM, Gaudieri S, Mallal S, Cover TL. Helicobacter pylori Adaptation In Vivo in Response to a High-Salt Diet. Infect Immun. 2015 Dec; 83(12): 4871-83.

Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci USA. 2014 Jan; 111(4): 1455-60.

Engler DB, Reuter S, van Wijck Y, Urban S, Kyburz A, Maxeiner J, Martin H, Yogev N, Waisman A, Gerhard M, Cover TL, Taube C, Müller A. Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proc Natl Acad Sci USA. 2014 Aug; 111(32): 11810-5.

Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM.  The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration. PLoS Pathog. 2014 Oct 16;10(10):e1004450.

Voss BJ, Gaddy JA, McDonald WH, Cover TL. Analysis of surface-exposed outer membrane proteins in Helicobacter pylori.  J Bacteriol. 2014 Jul; 196(13): 2455-71.

Johnson EM, Gaddy JA, Voss BJ, Hennig EE, Cover TL. Genes required for assembly of pili associated with the Helicobacter pylori cag type IV secretion system. Infect Immun. 2014 Aug; 82(8): 3457-70.

Radin JN, González-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS, Cover TL. Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect Immun. 2014 Jan; 82(1): 423-32.

Gaddy JA, Radin JN, Loh JT, Zhang F, Washington MK, Peek RM, Algood HM, Cover TL. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect Immun. 2013 Jun; 81(6): 2258-67.

Radin JN, Gaddy JA, González-Rivera C, Loh JT, Algood HM, Cover TL. Flagellar localization of a Helicobacter pylori autotransporter protein. MBio. 2013;4(2): e00613-12.

Chambers MG, Pyburn TM, González-Rivera C, Collier SE, Eli I, Yip CK, Takizawa Y, Lacy DB, Cover TL, Ohi MD. Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin. J Mol Biol. 2013 Feb; 425(3): 524-35.

Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM Jr, Cover TL, Solnick JV. Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathog. 2013 Feb;9(2):e1003189.

Serrano C, Wright SW, Bimczok D, Shaffer CL, Cover TL, Venegas A, Salazar MG, Smythies LE, Harris PR, Smith PD. Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children. Mucosal Immunol. 2013 Sep;6(5):950-959.

Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM Jr. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest. 2013 Jan;123(1):479-92.