M. Shane Hutson

Curriculum Vitae

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EDUCATION – DEGREES EARNED

University of Virginia
Wake Forest University
Wake Forest University
Ph.D., Biophysics
M.S., Physics
B.A., Physics
Minor in Mathematics
2000
1993
1992

Ph.D. Dissertation: Time-resolved Fourier transform infrared spectroscopy of light-driven ion pumps.
Mentor: Prof. Mark Braiman
M.S. Thesis: Two-dimensional motion of DNA bands during 120° pulsed-field gel electrophoresis.
Mentor: Prof. George Holzwarth


EMPLOYMENT HISTORY

Chair, Department of Physics & Astronomy, Vanderbilt University
Professor of Physics, Vanderbilt University
Professor of Biological Sciences, Vanderbilt University
Associate Professor of Physics, Vanderbilt University
Assistant Professor of Biological Sciences, Vanderbilt University
Assistant Professor of Physics, Vanderbilt University
Deputy Director for Biophotonics and Biomechanics, VIIBRE
Fellow, Vanderbilt Institute for Integrative Biosystem Research & Education (VIIBRE)
2017-Present
2016-Present
2016-Present
2010-2016
2006-2010
2003-2010
2013-Present
2003-2013
ORISE Faculty Fellow, National Center for Computational Toxicology,
U.S. Environmental Protection Agency
Visiting Professor, University of Waterloo, Ontario, Canada
2012-2013

2007

Postdoctoral Fellow in Biological Physics, Duke University
Department of Physics and Free Electron Laser Laboratory
Mentors: Prof. Glenn Edwards, Prof. Dan Kiehart
2000-2003

Professional Affiliations
American Physical Society (APS-Physics), Division of Biological Physics

HONORS & AWARDS

Society of Toxicology Bridging Award, 2013
Jeffrey Nordhaus Award for Excellence in Undergraduate Teaching, College of Arts & Science, Vanderbilt Univ., 2007
National Science Foundation Faculty Early Career Development (CAREER) Award, 2006
Coblentz Society Outstanding Student Award in Vibrational Spectroscopy, 2000
National Institutes of Health Biophysics Training Grant Fellow, 1996-1999
Dean’s Fellowship, University of Virginia, 1995-1999
magna cum laude, Wake Forest University, 1992
Guy T. Carswell Scholarship, Wake Forest University, 1988-1992
William Poteat Scholarship, Wake Forest University, 1988-1992
National Merit Scholar, 1988

 

RESEARCH

Publications

Refereed Journal Articles – Primary Research

  1. M.S. Hutson, M.C.K. Leung, N.C. Baker, R.M. Spencer and T.B. Knudsen (2017) “Computational model of secondary palate fusion and disruption” Chemical Research in Toxicology 2017 Jan 20: Epub ahead of print, https://dx.doi.org/10.1021/acs.chemrestox.6b00350.
  2. M.C.K. Leung, M.S. Hutson, A.W. Seifert, R.M. Spencer and T.B. Knudsen (2016) “Computational modeling and simulation of genital tubercle development” Reproductive Toxicology 64:151-61, http://dx.doi.org/10.1016/j.reprotox.2016.05.005.
  3. N. Lakomkin, H. Kang, B. Landman, M.S. Hutson, R.G. Abramson (2016) “The attenuation distribution across the long axis (ADLA): Preliminary findings for assessing response to cancer treatment” Academic Radiology 23(6): 718-723, http://dx.doi.org/10.1016/j.acra.2016.02.007.
  4. J. Kozub, J.-H. Shen, K.M. Joos, R. Prasad and M.S. Hutson (2015) “Optic nerve sheath fenestration using a Raman-shifted alexandrite laser”  Lasers in Surgery and Medicine 48: 270-280, http://dx.doi.org/10.1002/lsm.22456.
  5. S.M. Crews, W.T. McCleery and M.S. Hutson (2015) “Pathway to a Phenocopy: Heat Stress Effects in Early Embryogenesis” Developmental Dynamics 245: 402-413, https://doi.org/10.1002/dvdy.24360.
  6. J. Kozub, J.-H. Shen, K.M. Joos, R. Prasad and M.S. Hutson (2015) “Efficacy and predictability of soft tissue ablation using a prototype Raman-shifted alexandrite laser” Journal of Biomedical Optics 20(10): 105004 (Oct 12, 2015; 10 pp), https://doi.org/10.1117/1.JBO.20.10.105004.
  7. G. Kavanaugh, R. Zhao, Y. Guo, K.N. Mohni, G. Glick, M.E. Lacy, M.S. Hutson, M. Ascano and D. Cortez (2015) “Enhancer of Rudimentary Homolog affects the replication stress response through regulation of RNA processing” Molecular and Cellular Biology 35(17): 2979-2990, https://doi.org/ 10.1128/MCB.01276-14.
  8. G.W. Brodland, J.H. Veldhuis, S. Kim, M. Perrone, D. Mashburn and M.S. Hutson (2014) “CellFIT: a cellular force-inference toolkit using curvilinear cell boundaries” PLoS ONE 9: e99116 (15pp), https://doi.org/10.1371/journal.pone.0099116.
  9. H.E. Lynch, J. Veldhuis, G.W. Brodland and M.S. Hutson (2014) “Modeling cell elongation during germ band retraction: cell autonomy versus applied anisotropic stress” New Journal of Physics 16: 055003 (18pp), https://doi.org/10.1088/1367-2630/16/5/055003.
  10. Y. Yan, L. Jiang, K.J. Aufderheide, G.A. Wright, A. Terekhov, L. Costa, K. Qin, W.T. McCleery, J.J. Fellenstein, A. Ustione, J.B. Robertson, C.H. Johnson, D.W. Piston, M.S. Hutson, J.P. Wikswo, W. Hofmeister and C. Janetopoulos (2014) “A microfluidic-enabled mechanical microcompressor for the immobilization of live single- and multi-cellular specimens” Microscopy and Microanalysis 20(1): 141-151, https://doi.org/10.1017/S1431927613014037.
  11. H.E. Lynch, S.M. Crews, B. Rosenthal, E. Kim, R. Gish, K. Echiverri and M.S. Hutson (2013) “Cellular mechanics of germ band retraction in Drosophila” Developmental Biology 384: 205-213, https://doi.org/10.1016/j.ydbio.2013.10.005.
  12. A.K. Jayasinghe, S.M. Crews, D.N. Mashburn and M.S. Hutson (2013) “Apical oscillations in amnioserosa cells: basolateral coupling and mechanical autonomy” Biophysical Journal 105: 255-265, https://doi.org/10.1016/j.bpj.2013.05.027.
  13. D.N. Mashburn, H.E. Lynch, X. Ma, M.S. Hutson (2012) “Enabling user-guided segmentation and tracking of surface-labeled cells in time-lapse image sets of living tissues” Cytometry A 81A(5): 409-418, https://doi.org/10.1002/cyto.a.22034.
  14. M.A. Mackanos, D.M. Simanovskii, K.E. Schriver, M.S. Hutson, C.H. Contag, J.A. Kozub, E.D. Jansen (2012) “Pulse Duration Dependent Mid-Infrared Laser Ablation for Biological Applications” IEEE Journal of Selected Topics in Quantum Electronics 18(4): 1514-1522, https://doi.org/10.1109/JSTQE.2012.2188501.
  15. D. Azevedo, M. Antunes, S. Prag, X. Ma, U. Hacker, G.W. Brodland, M.S. Hutson, J. Solon, A. Jacinto (2011) “DRhoGEF2 Regulates Cellular Tension and Cell Pulsations in the Amnioserosa during Drosophila Dorsal Closure” PLoS ONE 6(9): e23964 (11pp), https://doi.org/10.1371/journal.pone.0023964.
  16. A. Jayasinghe, J. Rohner, M.S. Hutson (2011) “Holographic UV laser microsurgery” Biomedical Optics Express 2(9): 2590-2599, https://doi.org/10.1364/BOE.2.002590. (Online journal cover is a movie from this paper, https://www.osapublishing.org/boe/issue.cfm?volume=2&issue=9).
  17. J. Kozub, B. Ivanov, A. Jayasinghe, R. Prasad, J. Shen, M. Klosner, D. Heller, M. Mendenhall, D.W. Piston, K. Joos, M.S. Hutson (2011) “Raman-shifted alexandrite laser for soft tissue ablation in the 6- to 7-μm wavelength range” Biomedical Optics Express 2(5): 1275-1281, https://doi.org/10.1364/BOE.2.001275.
  18. G.W. Brodland, V. Conte, P.G. Cranston, J. Veldhuis, S. Narasimhan, M.S. Hutson, A. Jacinto, F. Ulrich, B. Baum, M. Miodownik (2010) “Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila” Proceedings of the National Academy of Sciences USA 107(51): 22111-22116, https://doi.org/10.1073/pnas.1006591107.
  19. M.S. Hutson, J. Veldhuis, X. Ma, H.E. Lynch, P.G. Cranston, G.W. Brodland (2009) “Combining laser microsurgery and finite element modeling to assess cell-level epithelial mechanics” Biophysical Journal 97: 3075-3085 (+4 pp online supplement), https://doi.org/10.1016/j.bpj.2009.09.034.
  20. M.S. Hutson, B. Ivanov, A. Jayasinghe, G. Adunas, Y. Xiao, M. Guo, J. Kozub (2009) “Interplay of wavelength, fluence and spot-size in free-electron laser ablation of cornea” Optics Express 17: 9840-9850, https://doi.org/10.1364/OE.17.009840.
  21. X. Ma, H.E. Lynch, P.C. Scully, M.S. Hutson (2009) “Probing embryonic tissue mechanics with laser hole drilling” Physical Biology 6: 036004 (12pp + 2pp online supplement), https://doi.org/10.1088/1478-3975/6/3/036004.
  22. M.S. Hutson, G.W. Brodland, J. Yang, and D. Viens (2008) “Cell Sorting in Three Dimensions: Topology, Fluctuations, and Fluidlike Instabilities” Physical Review Letters 101: 148105 (4pp + 3pp online supplement), https://doi.org/10.1103/PhysRevLett.101.148105. Featured in Vanderbilt Explorations (http://www.vanderbilt.edu/exploration/stories/cellsort.html).
  23. Y. Xiao, M. Guo, P. Zhang, G. Shanmugam, P. L. Polavarapu and M. S. Hutson (2008) “Wavelength-Dependent Conformational Changes in Collagen after Mid-Infrared Laser Ablation of Cornea” Biophysical Journal 94(4): 1359-1366, https://doi.org/10.1529/biophysj.107.114389.
  24. M. S. Hutson and X. Ma (2007) “Plasma and Cavitation Dynamics during Pulsed Laser Microsurgery in vivo”, Physical Review Letters 99(15): 158104 (4pp), https://doi.org/10.1103/PhysRevLett.99.158104. Featured news item in Laser Focus World (Nov 2007), Biophotonics (Dec 2007), and Vanderbilt Explorations (http://www.vanderbilt.edu/exploration/stories/lasercut.html).
  25. G.S. Edwards, R.D. Pearlstein, M.L. Copeland, M.S. Hutson, K. Latone, A. Spiro and G. Pasmanik (2007) “6450 nm wavelength tissue ablation using a nanosecond laser based on difference frequency mixing and stimulated Raman scattering” Optics Letters 32(11): 1426-1428, https://doi.org/10.1364/OL.32.001426.
  26. X.G. Peralta, Y. Toyama, Y. Tokutake, M.S. Hutson, S. Venakides, D.P. Kiehart, and G.S. Edwards (2007) “Upregulation of Forces and Morphogenic Asymmetries in Dorsal Closure during Drosophila Development”, Biophysical Journal 92: 2583-2596 (+ 3pp online supplement), https://doi.org/10.1529/biophysj.106.094110.
  27. Y. Xiao, M. Guo, K. Parker and M.S. Hutson (2006) “Wavelength-Dependent Collagen Fragmentation during Mid-IR Laser Ablation”, Biophysical Journal 91: 1424-1432, https://doi.org/10.1529/biophysj.106.084616.
  28. Y. Xiao, M.S. Hutson, M. Belenky, J. Herzfeld, M.S. Braiman (2004) “Role of Arginine-82 in Fast Proton Release during the Bacteriorhodopsin Photocycle: A Time-Resolved FT-IR Study of Purple Membranes Containing 15N-Labeled Arginine”, Biochemistry 43: 12809-12818, https://doi.org/10.1021/bi049238g.
  29. M.S. Hutson, Y. Tokutake, M.-S. Chang, J.W. Bloor, S. Venakides, D.P. Kiehart, G.S. Edwards (2003) “Forces for Morphogenesis Investigated with Laser Microsurgery and Quantitative Modeling” Science 300: 145-149 (+ 19pp online supplement), https://doi.org/10.1126/science.1079552.
  30. G.S. Edwards and M.S. Hutson (2003) “Advantage of the Mark-III FEL for biophysical research and biomedical applications” Journal of Synchrotron Radiation 10: 354-357, https://doi.org/10.1107/S0909049503007970.
  31. M.S. Hutson, S.A. Hauger and G. Edwards (2002) “Thermal diffusion and chemical kinetics in laminar biomaterial due to heating by a free-electron laser” Physical Review E 65: 061906 (6pp), https://doi.org/10.1103/PhysRevE.65.061906.
  32. M.S. Hutson, R.A. Palmer, M.-S. Chang, A. Gillikin, V. Litvinenko and G. Edwards (2002) “Commissioning of a UV/time-resolved-FTIR beamline at the Duke FEL laboratory” Nuclear Instruments and Methods in Physics Research A 483: 560-564, https://doi.org/10.1016/S0168-9002%2802%2900382-0.
  33. G.D. Smith, M.S. Hutson, Y. Lu, M.T. Tierney, M.W. Grinstaff and R.A. Palmer (2001) “Step-Scan FT-IR Time-Resolved Spectroscopy in the Solid State” Applied Spectroscopy 55: 637-642, https://doi.org/10.1366/0003702011952262.
  34. M.S. Hutson, S.V. Shilov, R. Krebs and M.S. Braiman (2001) “Halide Dependence of the Halorhodopsin Photocycle as Measured by Time-Resolved Infrared Spectra” Biophysical Journal 80: 1452-1465, https://doi.org/10.1016/S0006-3495%2801%2976117-6.
  35. M.S. Hutson, U. Alexiev, S.V. Shilov, K.J. Wise and M.S. Braiman (2000) “Evidence for a Perturbation of Arginine-82 in the Bacteriorhodopsin Photocycle from Time-Resolved Infrared Spectra” Biochemistry 39: 13189-13200, https://doi.org/10.1021/bi000426q.
  36. M.S. Hutson and M.S. Braiman (1999) “Application of doubled-angle phase correction method to time-resolved step-scan FT-IR spectra” Vibrational Spectroscopy 19: 381-385, https://doi.org/10.1016/S0924-2031%2898%2900090-3.
  37. M.S. Hutson and M.S. Braiman (1998) “Direct Phase Correction of Differential FT-IR Spectra” Applied Spectroscopy 52: 974-984, https://www.osapublishing.org/as/abstract.cfm?uri=as-52-7-974.
  38. M.S. Hutson, G. Holzwarth, T. Duke and J. Viovy (1995) “Two-Dimensional Motion of DNA Bands During 120° Pulsed-Field Gel Electrophoresis. I. Effect of Molecular Weight.” Biopolymers 35: 297-306, https://doi.org/10.1002/bip.360350305.
  39. L.M. Neitzey, M.S. Hutson and G. Holzwarth (1993) “Two-dimensional motion of DNA bands during 120° pulsed-field gel electrophoresis.” Electrophoresis 14: 296-303, https://doi.org/10.1002/elps.1150140152.

 

Refereed Journal Articles – Reviews

  1. M.S. Hutson, P.G. Alexander, V. Allwardt, D.M. Aronoff, K.L. Bruner-Tran, D.E. Cliffel, J.M. Davidson, A. Gough, D.A. Markov, L.J. McCawley, J.R. McKenzie, J.A. McLean, K.G. Osteen, V. Pensabene, P.C. Samson, N.K. Senutovitch, S.D. Sherrod, M.S. Shotwell, D.L. Taylor, L.M. Tetz, R.S. Tuan, L.A. Vernetti and J.P. Wikswo (2016) “Organs-on-Chips as Bridges for Predictive Toxicology” Applied In Vitro Toxicology 2(2): 97-102, https://doi.org/10.1089/aivt.2016.0003.
  2. M.E. Lacy and M.S. Hutson (2016) “Amnioserosa development and function in Drosophila embryogenesis: critical mechanical roles for an extraembryonic tissue” Developmental Dynamics 245(5): 558-568, https://doi.org/10.1002/dvdy.24395.
  3. M.S. Hutson and X. Ma (2008) “Mechanical aspects of developmental biology: perspectives On Growth and Form in the (post)-genomic age” Physical Biology 5(1): 015001 (8pp), https://doi.org/10.1088/1478-3975/5/1/015001.
  4. G.S. Edwards, R.H. Austin, F.E. Carroll, M.L. Copeland, M.E. Couprie, W.E. Gabella, R.F. Haglund, B.A. Hooper, M.S. Hutson, E.D. Jansen, K.M. Joos, D.P. Kiehart, I. Lindau, J. Miao, H.S. Pratisto, J.H. Shen, Y. Tokutake, A.F.G. van der Meer, A. Xie (2003) “Free-electron-laser-based biophysical and biomedical instrumentation”, Review of Scientific Instruments 74: 3207-3245, https://doi.org/10.1063/1.1584078.

 

Book Chapters

  1. J.H. Veldhuis, D. Mashburn, M.S. Hutson, G.W. Brodland “Practical Aspects of the Cellular Force Inference Toolkit (CellFIT)”, in Methods in Cell Biology Volume 125: Biophysical Methods in Cell Biology, edited by E. Paluch, Chapter 18, pp. 331-351 (Elsevier, 2015), https://doi.org/10.1016/bs.mcb.2014.10.010.
  2. D.P. Kiehart, Y. Tokutake, M.-S. Chang, M.S. Hutson, J. Wiemann, X.G. Peralta, Y. Toyama, A.R. Wells, A. Rodriguez, and G.S. Edwards “Ultraviolet Laser Microbeam for Dissection of Drosophila Embryos”, in Cell Biology: A Laboratory Handbook, 3rd Edition, edited by J.E. Celis, Chapter 9, pp. 87-103, (Elsevier,  2006), https://doi.org/10.1016/B978-012164730-8/50137-4.

 

Published Conference Proceedings (Refereed)

  1. M.S. Hutson and G.S. Edwards (2004) “Advances in the Physical Understanding of Laser Surgery at 6.45 Microns”, Proceedings of the 26th International Free Electron Laser Conference and 11th FEL Users Workshop: FRAIS01. Published in JACoW (6pp), http://accelconf.web.cern.ch/AccelConf/f04/papers/FRAIS01/FRAIS01.PDF.

 

Published Conference Proceedings (Non-refereed)

  1. M.S. Hutson, G.W. Brodland, X. Ma, H.E. Lynch, A.K. Jayasinghe, J. Veldhuis, “Measuring and Modeling Morphogenetic Stress in Developing Embryos” in Mechanics of Biological Systems and Materials (Conference Proceedings of the Society for Experimental Mechanics) Vol. 4, pp. 107-115 (Lombard, IL, 2013), https://doi.org/10.1007/978-3-319-00777-9_15.
  2. M.S. Hutson, Y. Xiao and M. Guo, “Protein structural failure in mid-IR laser ablation of cornea” High Power Laser Ablation VI, SPIE 6261: 62612N – 10 pages (Taos, NM, May 2006), https://doi.org/10.1117/12.669004.
  3. G.S. Edwards, M.S. Hutson and S. Hauger, “Heat diffusion and chemical kinetics in Mark-III FEL tissue ablation” Commercial & Biomedical Applications of Ultrafast and Free Electron Lasers, SPIE 4633: 184-193 (San Jose, CA, 2002), https://doi.org/10.1117/12.461378.
  4. G. Edwards, M.S. Hutson, S. Hauger, J. Kozub, J. Shen, C. Shieh, K. Topadze and K. Joos, “Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns” Commercial & Biomedical Applications of Ultrafast and Free Electron Lasers, SPIE 4633: 194-201 (San Jose, CA, 2002), https://doi.org/10.1117/12.461379.
  5. M.S. Hutson, R.A. Palmer, A. Gillikin, M.-S. Chang, V.N. Litvinenko and G.S. Edwards, “UV/time-resolved FTIR beamline at the Duke FEL Laboratory” Commercial & Biomedical Applications of Ultrafast and Free Electron Lasers, SPIE 4633: 225-232 (San Jose, CA, 2002), https://doi.org/10.1117/12.461383.
  6. M. Emamian, G. Swift and M.S. Hutson “Optical beam line design for the Duke Free Electron Laser Laboratory” Proceedings of the 2001 Particle Accelerator Conference 4: 2524-2526 (Chicago, 2001), https://accelconf.web.cern.ch/accelconf/p01/PAPERS/WPPH036.PDF.
  7. G. Edwards, C. Fowler, S. Hutson, V. Litvinenko, R.A. Palmer and B. Roberts “Light source capabilities and applications research at the Duke FEL Laboratory” Biomedical Applications of Free Electron Lasers, SPIE 3925: 106-115 (San Jose, CA, 2000), https://doi.org/10.1117/12.384258

 

Editorials

  1. 49. M.S. Hutson (2008) “Physical Aspects of Developmental Biology: 21st Century Perspectives On Growth and FormPhysical Biology 5(1): preface (1p), https://doi.org/10.1088/1478-3975/5/1/E01.

 

Patents

  1. K. Joos, J.-H. Shen, M.S. Hutson and J. Kozub, “Apparatus and Method for Real-Time Imaging and Monitoring of an Electrosurgical Procedure,” U.S. Patent No. 8,655,431 (Feb 2014) based on U.S. Provisional Patent Application 13/149,502 (May 2011), https://www.google.com/patents/US8655431.
  2. M.S. Hutson and G.S. Edwards, “Method and Apparatus for Infrared Tissue Ablation”, U.S. Patent No. 8,074,661 (Dec 2011) based on U.S. Provisional Patent Application #60/384,877 (May 2002), https://www.google.com/patents/US8074661.

 

Research Grants Received

  1. “FlpOn: an optogenetic circuit for user-designed mosaics and its application to wound healing”
    National Institutes of Health 1R21AR068933-01
    Principal Investigator: Andrea Page-McCaw, Vanderbilt University
    Co-Investigator: M. Shane Hutson
    Total Costs: $368,589; Period of Award: 5/1/2015 – 4/30/2017
  2. “Vanderbilt-Pittsburgh Resource for Organotypic Models for Predictive Toxicology (VPROMPT)”
    U.S. Environmental Protection Agency STAR Center R835736
    Project Director: M. Shane Hutson
    Co-PIs: Lisa McCawley, Kevin Osteen, Rocky Tuan, Lansing Taylor, John Wikswo
    Co-Is: David Aronoff, Kaylon Bruner-Tran, David Cliffel, Jeffrey Davidson, Albert Gough, Dmitry Markov, John McClean, Matthew Shotwell, Lawrence Vernetti
    Total Costs: $6,000,000 ($3,761,827 for Vanderbilt; $2,238,173 passed through to U. Pittsburgh); Period of Award: 12/1/2014-11/30/2018
  3. “Optogenetic and Pharmacological Investigations of Epithelial Wound Detection”
    Vanderbilt University Discovery Grant
    Principal Investigators: M. Shane Hutson and Andrea Page-McCaw
    Total Costs: $100,000; Period of Award: 5/11/2012 – 6/30/2015
  4. “Cellular Biomechanics of Heat-Shock Induced Defects in Drosophila Embryogenesis”
    National Institutes of Health 1 R01 GM099107-01
    Principal Investigators: M. Shane Hutson and G. Wayne Brodland
    Total Costs: $1,386,303; Period of Award: 7/1/2011 – 4/30/2016
  5. “A Clinically Practical Laser System for Neurosurgery”
    National Institutes of Health Phase II SBIR (Small Business Innovation Research)
    Principal Investigator: Donald Heller, Light Age, Inc.
    Co-Lead Investigators for Research Institution Partner: M. Shane Hutson and Karen Joos
    Total Costs: $750,000 ($250,000 for Vanderbilt subcontract); Period of Award: 7/15/2010 – 7/14/2012
  6. “Dual-Functionality Laser System For High-Contrast Diagnostic Imaging And Precision Surgery”
    Department of Defense Phase II STTR Program (Small business Technology TRansfer)
    Principal Investigator: Marc Klosner, Light Age, Inc.
    Lead Investigator for Research Institution Partner: M. Shane Hutson
    Total Costs: $850,000 ($225,000 for Vanderbilt subcontract); Period of Award: 9/8/2009 – 9/7/2011
  7. “Spinning Disk Confocal Microscope System with Photobleaching, Photoactivation, and Photoablation”
    National Institutes of Health Major Research Instrumentation
    Principle Investigators: Chris Janetopoulos and Donna Webb, Vanderbilt University
    Major Users: Kevin Ess, M. Shane Hutson, Irina Kaverina, Ann Kenworthy, Ryoma Ohi, Matthew Tyska
    Total Costs: $500,000; Period of Award: 4/1/2009 – 3/31/2010
  8. “Integrating the genetics, mechanics and phenomenology of embryonic wound healing”
    Human Frontier Science Program
    Principal Applicant: M. Shane Hutson
    Co-applicants: Antonio Jacinto, Institute of Molecular Medicine, Lisbon, Portugal; and G. Wayne Brodland, University of Waterloo, Waterloo, Ontario, Canada
    Total Costs: $1,050,000 ($350,000 to Vanderbilt); Period of Award: 7/1/2007 – 6/30/2010
  9. “CAREER – Forces Underlying Germ Band Retraction in Drosophila Embryogenesis”
    National Science Foundation
    Principal Investigator: M. Shane Hutson
    Total Costs: $832,833; Period of Award: 2/1/2006 – 1/31/2011
  10. “Vanderbilt Free-Electron Laser Center for Research in Surgery, Medicine, Photobiology and Materials Science: Supplemental Applications: Anomalous Wavelength Dependence.”
    Department of Defense Medical Free Electron Laser Program
    Program Director and Principal Investigator: David Piston, Vanderbilt University
    Co-Principal Investigator: M. Shane Hutson
    Total Costs: $168,326; Period of Award: 6/1/2004 – 1/31/2006
    Total Costs: $142,244; Period of Award: 7/1/2006 – 1/31/2007

 

Invited Presentations

  1. Society of Toxicology Annual Meeting, EPA STAR Center Kickoff Session, San Diego, CA, March 25, 2015, “VPROMPT: Vanderbilt-Pittsburgh Resource for Organotypic Models for Predictive Toxicology”
  2. March Meeting of the American Physical Society, Invited Session on Mechanical Interactions and Pattern Formation in Multicellular Systems, San Antonio, TX, March 6, 2015, “Cell mechanics and non-genetic developmental defects”
  3. Photonics West, Optical Methods in Developmental Biology III, San Francisco, CA, February 7, 2015, “Reverse engineering morphogenesis in embryonic epithelia: time-lapse confocal microscopy, laser microsurgery, and force inference from cell shape”
  4. Vanderbilt University, Nashville, TN, Molecular Biophysics Training Program / Center for Structural Biology Seminar, December 2, 2014 “From non-specific environmental stresses to adverse developmental outcomes: the role of cellular mechanics”
  5. QuanTissue Meeting on the Physics of Biological Systems: Visualization and Manipulation of Cellular Communities, Helmholtz Zentrum münchen (German Research Center for Environmental Health), Munich, Germany, October 10, 2014, “Cellular mechanics in early embryogenesis: a mechanical assist from an extra-embryonic tissue”
  6. Vanderbilt University, Nashville, TN, Biophotonics Seminar, September 30, 2014 “Imaging, Image Analysis and Optical Manipulation of Cellular Mechanics in Early Embryogenesis”
  7. 7th World Congress of Biomechanics (a quadrennial event), Symposium on Mechanics of Tissue and Organ Development, Boston, MA, July 8, 2014. “Measuring morphogenetic stresses and dynamic mechanical properties in live embryos”
  8. Annual Drosophila Research Conference, Workshop on Developmental Mechanics, San Diego, CA, March 28, 2014, “Cellular mechanics of germband retraction”
  9. Society for Experimental Mechanics Annual Conference & Exposition on Experimental and Applied Mechanics, Lombard, IL, June 5, 2013, “Measuring and Modeling Residual Morphogenetic Stress in Developing Embryos”
  10. Kennesaw State University, Kennesaw, GA, Molecular Biology Seminar, February 1, 2013, “Tissue fusion events during embryogenesis: microsurgery, mechanics and modeling”
  11. U.S. Environmental Protection Agency, Research Triangle Park, NC, Virtual Embryo Seminar, October 31, 2012, “Probing oscillatory cell shape changes using holographic laser microsurgery”
  12. Duke University, Biological Physics Research Group, Durham, NC, October 25, 2012, “Probing oscillatory cell shape changes using holographic laser microsurgery”
  13. Tissue Growth and Morphogenesis: from Genetics to Mechanics and Back, Banff International Research Station for Mathematical Innovation and Discovery (BIRS), Banff, Alberta, Canada, July 26, 2012, “Probing oscillatory cell shape changes using holographic laser microsurgery”
  14. Workshop on Cell Signaling and Cytoskeleton in Directed Cell Migration, Vanderbilt University, Nashville, TN, March 6, 2012, “Putting models of collective migration to the test using laser-microsurgery”
  15. Yeshiva University, New York, NY, Physics Colloquium, May 1, 2012, “Putting models of morphogenesis to the test using laser-microsurgery”
  16. Instituto Gulbenkian de Ciência, Lisbon, Portugal, January 13, 2012, “Dissecting cellular biomechanics in Drosophila embryogenesis”
  17. 78th Annual Meeting of SESAPS – Southeastern Section of the American Physical Society, Roanoke, VA, October 21, 2011 “Dissecting cellular biomechanics with a laser”
  18. 3rd Frontiers Symposium on the Mechanics of Development, Farmington, PA, June 21, 2011 “Measuring the sub-cellular mechanics that drive tissue-level morphogenesis”
  19. Human Frontier Science Program Awardees Meeting, Kovalam, Kerala, India, November 3, 2010 “Cell-shape changes, forces and genes: Integrating the genetics, mechanics and phenomenology of embryonic wound healing”
  20. Université de Nice-Sophia Antipolis, Nice, France, Conference on Modeling and Biomechanics of Morphogenesis and Tissue Repair, May 25, 2010 “Deconstructing epithelial morphogenesis using laser-microsurgery”
  21. March Meeting of the American Physical Society, Portland, OR, Invited talk for a Division of Biological Physics Focus Session on “Self-organization in Tissues”, March 17, 2010 “Epithelial self-organization in fruit fly embryogenesis”
  22. Instituto Gulbenkian de Ciência, Lisbon, Portugal, December 1, 2009 “Mechanics of Morphogenesis”
  23. Vanderbilt University, Nashville, TN, Biomedical Engineering Seminar, November 17, 2009 “How does a fly make itself? Dissecting morphogenesis with laser microsurgery”
  24. Indiana University, Bloomington, IN, Biocomplexity X Conference: Quantitative Tissue Biology and Virtual Tissues, October 28, 2009 “Modeling microsurgical interventions in morphogenesis”
  25. University of Michigan, Ann Arbor, MI, Biological Physics/Complex Systems Seminar, October 5, 2009 “How does a fly make itself? Dissecting morphogenesis with laser microsurgery”
  26. Vanderbilt University, Nashville, TN, Physics & Astronomy Colloquium, September 17, 2009 “How does a fly make itself? Dissecting morphogenesis with laser microsurgery”
  27. Indiana University, Bloomington, IN, CompuCell3D Workshop, August 17, 2009 “How does a fly make itself? Dissecting morphogenesis with laser microsurgery”
  28. St Vincent College, Latrobe, PA, Physics Colloquium, March 19, 2009 “Dissecting the mechanics of developmental biology with laser microsurgery”
  29. Vanderbilt University, Nashville, TN, Cell and Developmental Biology Seminar, February 23, 2009 “Probing epithelial mechanics with laser microsurgery”
  30. Joint Annual Conference of the National Society of Black Physicists and the National Society of Hispanic Physicists, Nashville, TN, February 12, 2009 “Probing the mechanics of morphogenesis with laser hole-drilling”
  31. Wake Forest University, Winston-Salem, NC, Physics Colloquium (I) and Annual Alumni Colloquium (II), November 6-7, 2008 “How does a fly make itself? I. Dissecting morphogenesis with laser-microsurgery. II. Modeling cell-level mechanics.”
  32. Ohio University, Athens, OH, Physics & Astronomy Colloquium, September 26, 2008 “How does a fly make itself? Dissecting morphogenesis with laser-microsurgery”
  33. Institute of Molecular Medicine, Lisbon, Portugal, Developmental Biology Seminar, July 4, 2008 “How does a fly make itself? The mechanics of morphogenesis”
  34. Ohio State University, Columbus, OH, Biophysics Seminar, March 5 2008 “How does a fly make itself? Dissecting morphogenesis with laser-microsurgery”
  35. Boston College, Boston, MA, Physical Chemistry Seminar, January 10, 2008. “Wavelength-dependent structural failure of collagen during mid-IR laser surgery”
  36. Syracuse University, Syracuse, NY, Chemistry Colloquium, October 23, 2007. “Structural failure of the protein matrix during mid-IR laser surgery”
  37. University of South Florida, Tampa, FL. Physics Colloquium, March 2, 2007. “Laser Ablation and Tissue Dynamics from Picoseconds to Minutes and Molecules to Cells”
  38. University of Wisconsin, Madison, WI, Workshop on New Research Opportunities in the UV and Soft X-ray Region with Linac-Driven Free Electron Laser Sources, October 2006. “Potential Applications of UV-FELs for Probing (and Manipulating?) Protein Dynamics”
  39. Vanderbilt University, Nashville, TN, Biological Sciences Seminar, March 2006. “Of Flies and Physics (and maybe a little scientific philosophy)”
  40. Jefferson Lab, Newport News, VA, Workshop on Free Electron Laser Applications for Biology and Medicine, June 2005. “Photothermal Chemistry of Collagen During Mid-IR Laser Ablation”
  41. Duke University, Durham, NC, Workshop on Novel Research Opportunities Using the Duke Storage Ring FEL (SR FEL), February 2005. “Time-Resolved Broadband IR Spectroscopy with a UV-FEL-Pump/Synchrotron-IR Probe Beam Line”.
  42. Fisk University, Nashville, TN, Joint Seminar: Dept of Physics and Div of Natural Sciences and Mathematics, November 2004. “Physical Biology (or Biological Physics) of Morphogenesis”
  43. 26th International Free Electron Laser Conference and 11th FEL User’s Workshop, Trieste, Italy, August 2004. “Advances in the Physical Understanding of Laser Surgery at 6.45 microns”
  44. Albert Einstein College of Medicine, New York, NY, Anatomy & Structural Biology Seminar, April 2003. “Forces for Morphogenesis:  Laser-microsurgery and Quantitative Modeling Applied to Dorsal Closure”
  45. Indiana University, Bloomington, IN, Physics Colloquium, February 2003. “Forces for Morphogenesis:  Laser-microsurgery and Quantitative Modeling Applied to Dorsal Closure”
  46. Texas A&M University, College Station, TX, Biomedical Engineering Seminar, February 2003. “Forces for Morphogenesis:  Laser-microsurgery and Quantitative Modeling Applied to Dorsal Closure”
  47. Vanderbilt University, Nashville, TN, Physics & Astronomy Colloquium, January 2003. “Forces for Morphogenesis:  Laser-microsurgery and Quantitative Modeling Applied to Dorsal Closure”
  48. Colgate University, Hamilton, NY, Physics & Astronomy Colloquium, February 2002. “Unraveling the Role of Arginine-82 in the Bacteriorhodopsin Photocycle”
  49. Wake Forest University, Winston-Salem, NC, Physics Colloquium, April 2001. “Unraveling the Role of Arginine-82 in the Bacteriorhodopsin Photocycle”
  50. University of Virginia, Charlottesville, VA, Biophysics Seminar, March 1998. “Direct Phase Correction of Differential FT-IR Spectra”

 

Conference Presentations with Published Abstracts

  1. A. Agyapong, A. Auner, M.S. Hutson “Preliminary Application of Optical Trapping: Calculating Forces on Beads in Solution” Annual Biomedical Research Conference for Minority Students (ABRCMS), Seattle, WA, November 2015. Student Presentation Awardee
  2. N. Lakomkin, A. Hainline, H. Kang, M.S. Hutson, C.L. Arteaga, R.G. Abramson “The attenuation distribution across the long axis (ADLA): Evaluation of predictive performance in a large clinical trial” Radiological Society of North America, Chicago, IL, December 2015.
  3. N. Lakomkin, H. Kang, M.S. Hutson, B. Landman, R.G. Abramson “The Attenuation Distribution across the Long Axis: Preliminary Findings for Assessing Response to Cancer Treatment” 63rd Annual Meeting of the Association of University Radiologists, New Orleans, LA, April 2015.
  4. W.T. McCleery, J. Veldhuis, G.W. Brodland, S.M. Crews, M.S. Hutson “Modeling the Epithelial Morphogenesis of Germ Band Retraction in Three Dimensions” American Physical Society March Meeting, San Antonio, TX, March 2015.
  5. E. Shannon, M.E. Lacy, M.S. Hutson, A. Page-McCaw “An optogenetic approach to assess tissue mechanics in epithelial wound detection” 56th Annual Drosophila Research Conference, Chicago, IL, March 2015.
  6. W.T. McCleery, S.M. Crews, D.N. Mashburn, J. Veldhuis, G.W. Brodland, M.S. Hutson “Inverse and 3D forward modeling of epithelial morphogenesis during germ band retraction” 7th World Congress of Biomechanics, Boston, MA, July 2014.
  7. M. Lacy, M.S. Hutson, A. Page-McCaw, K. LaFever “Controlling lamellipodial crawling during germ band retraction using photoactivation of Rac1” 7th World Congress of Biomechanics, Boston, MA, July 2014.
  8. N.S. Sipes, M.S. Hutson, N. Baker, T.B. Knudsen “Systems biology approach for predictive toxicology of cleft palate” Toxicology and Risk Assessment Conference, Cincinnati, OH, April 2014.
  9. M.C.K. Leung, N.S. Sipes, N.C. Baker, B. Ahir, C.J. Wolf, A.W. Siefert, M.S. Hutson, S.D. Perrault, R.M. Spencer, T.B. Knudsen “Computational embryology and predictive toxicology of hypospadias” Society of Toxicology Annual Meeting, Phoenix, AZ, March 2014.
  10. D.N. Mashburn, M.S. Hutson, J.H. Veldhuis, G.W. Brodland “Noise sensitivity in force-inference techniques” American Physical Society March Meeting, Denver, CO, March 2014.
  11. S.M. Crews, W.T. McCleery, M.S. Hutson “Mechanical analysis of a heat-shock induced developmental defect” American Physical Society March Meeting, Denver, CO, March 2014.
  12. W.T. McCleery, S.M. Crews, D.N. Mashburn, J. Veldhuis, G.W. Brodland, M.S. Hutson “Modeling the morphogenesis of epidermal tissues on the surface of a 3D last” American Physical Society March Meeting, Denver, CO, March 2014.
  13. M.S. Hutson, E.C. Rericha “Initial experience with a calculus-based IPLS course at Vanderbilt” American Physical Society March Meeting, Denver, CO, March 2014.
  14. N.S. Sipes, M.S. Hutson, N. Baker, B.D. Abbott, T.B. Knudsen “Computational embryology and predictive toxicology of cleft palate” Teratology Society Annual Meeting, Tuscon, AZ, June 2013.
  15. D. Mashburn, A. Jayasinghe, M.S. Hutson “Volumetric measurements of amnioserosa cells in developing DrosophilaAmerican Physical Society March Meeting, Baltimore, MD, March 2013.
  16. M.S. Hutson, D. Mashburn, E. Copenhaver, W.T. McCleery, J. Veldhuis, S. Kim, G.W. Brodland “In-plane video force microscopy of morphogenesis in epithelia” American Physical Society March Meeting, Baltimore, MD, March 2013.
  17. M.S. Hutson and T.B. Knudsen “Cell-level Model of Morphogenetic Tissue Fusion for Computational Toxicology”, Society of Toxicology Annual Meeting, San Antonio, TX, March 10-14, 2013.
  18. K. Joos, J. Kozub, J. Shen, R. Prasad, M.S. Hutson “Evaluation of Raman-shifted alexandrite laser fenestration of optic nerve sheaths”, 33rd Annual Conference of the American Society for Laser Medicine and Surgery, Boston, MA, April 2013.
  19. S. Crews, X. Ma, S. Lawrence and M.S. Hutson “Passive cellular microrheology in developing fruit fly embryos” American Physical Society March Meeting, Boston, MA, March 2012.
  20. H.E. Lynch, E. Kim, R. Gish and M.S. Hutson “Cell autonomous shape changes in germband retraction” American Physical Society March Meeting, Boston, MA, March 2012.
  21. A. Jayasinghe, D.N. Mashburn and M.S. Hutson “Investigation of autonomous cell dynamics using holographic laser microsurgery” American Physical Society March Meeting, Boston, MA, March 2012.
  22. D. Mashburn, X. Ma, S. Crews, H. Lynch, W.T. McCleery, M.S. Hutson “Quantifying cell behaviors during embryonic wound healing” American Physical Society March Meeting, Dallas, TX, March 2011.
  23. M.S. Hutson, J. Rohner, S. Crews, W.T. McCleery, W.B. Robinson “A cellular Potts model of germband retraction and dorsal closure” American Physical Society March Meeting, Dallas, TX, March 2011.
  24. X. Ma and M.S. Hutson “Probing the mechanics of pulsed contractions in embryonic epithelial cells” American Physical Society March Meeting, Portland, OR, March 2010.
  25. H.E. Lynch, B. Rosenthal, E. Kim, R. Gish and M.S. Hutson “Probing the forces of germband retraction with laser-microsurgery” American Physical Society March Meeting, Portland, OR, March 2010.
  26. A. Jayasinghe and M.S. Hutson “Simultaneous multi-point laser ablation using a spatial light modulator” American Physical Society March Meeting, Portland, OR, March 2010.
  27. H.E. Lynch, B. Rosenthal, E.J. Kim, R.C. Gish and M.S. Hutson “Tissue-level Mechanics during Germ Band Retraction in Drosphila Embryos” ASCB/JSCB/RIKEN CDB Meeting On Building The Body Plan: How Cell Adhesion, Signaling, And Cytoskeletal Regulation Shape Morphogenesis, Kyoto, Japan, September 2009.
  28. X. Ma, H.E. Lynch and M.S. Hutson “Epithelial Mechanics during Germband Retraction in Fruit Fly Embryogenesis” American Physical Society March Meeting, Pittsburgh, PA, March 2009.
  29. A.K. Jayasinghe, B. Ivanov and M.S. Hutson “Efficiency and Plume Dynamics for Mid-IR Laser Ablation of Cornea” American Physical Society March Meeting, Pittsburgh, PA, March 2009.
  30. M.S. Hutson, D.N. Mashburn, X. Ma and H.E. Lynch “Evaluating Epithelial Mechanics with Laser Hole-drilling” American Physical Society March Meeting, Pittsburgh, PA, March 2009.
  31. M.S. Hutson, X. Ma, H.E. Lynch and P.C. Scully “Mechanics of apical constriction in amnioserosa cells during dorsal closure” Annual Drosophila Research Conference, Chicago, IL, March 2009.
  32. T. Yan and M.S. Hutson “A microfluidic device for organizing temporally-ordered arrays of C. elegans embryos from one single parent” Joint Annual Conference of the National Society of Black Physicists and the National Society of Hispanic Physicists, Nashville, TN, February 2009
  33. H.E. Lynch, B. Rosenthal and M.S. Hutson “Force Anisotropy during Germ Band Retraction in Drosophila Embryos” American Society for Cell Biology Annual Meeting, San Francisco, CA, December 2008
  34. M.S. Hutson, X. Ma, H.E. Lynch, D.N. Mashburn, P.C. Scully, J. Velduis, G.W. Brodland, A. Jacinto “Laser-incisions of Embryonic Epithelial Cells: Correlating the Observed Recoil Dynamics with Cell-level Mechanical Models” Human Frontiers Science Program Awardees Meeting, Berlin, Germany, July 2008
  35. X. Ma and M.S. Hutson “Laser Hole-Drilling as a Probe of Morphogenetic Stresses in Embryonic Epithelia: Experimental Observations” American Physical Society March Meeting, New Orleans, LA, March 2008.
  36. M.S. Hutson , X. Ma , J. Veldhuis and G.W. Brodland “Laser Hole-Drilling as a Probe of Morphogenetic Stresses in Embryonic Epithelia: Finite Element Models” American Physical Society March Meeting, New Orleans, LA, March 2008.
  37. X. Ma and M.S. Hutson “Recoil Dynamics after Laser Ablation of Single Cell Edges in Embryonic Epithelia” American Physical Society March Meeting, Denver, CO, March 2007.
  38. M.S. Hutson, G. Adunas and Y. Xiao “Confounding Effect of Spot-Size on the Wavelength-Dependence of Tissue Ablation Metrics” American Physical Society March Meeting, Denver, CO, March 2007.
  39. X. Ma, P. Scully and M.S. Hutson, “Determination of Intercellular Forces during Drosophila Embryogenesis” American Society for Cell Biology Annual Meeting, San Diego, CA, December 2006.
  40. X. Ma and M.S. Hutson, “Quantifying the Intercellular Forces during Drosophila Morphogenesis” American Physical Society March Meeting, Baltimore, MD, March 2006.
  41. M.S. Hutson and Y. Xiao “Wavelength-Dependent Conformational Changes of Collagen in Mid-IR Ablation” American Physical Society March Meeting, Baltimore, MD, March 2006.
  42. G. Adunas, Y. Xiao and M.S. Hutson “Energy Partitioning in FEL Tissue Ablation” American Physical Society March Meeting, Los Angeles, CA, March 2005.
  43. Y. Xiao and M.S. Hutson “FTIR Spectroscopy of the Non-volatile Components of the Plume during Laser Ablation of Cornea” American Chemical Society National Meeting, San Diego, CA, March 2005.
  44. X.G. Peralta, Y. Toyama, A. Wells, Y. Tokutake, M.S. Hutson, S. Venakides, D.P. Kiehart, G.S. Edwards “Force regulation during dorsal closure in Drosophila” American Society for Cell Biology Annual Meeting, Washington, DC, December 2004.
  45. M.S. Hutson, Y. Tokutake, M. Chang, JW Bloor, S Venakides, DP Kiehart, GS Edwards, “Measuring the forces that drive morphogenesis: Laser-microsurgery and quantitative modeling applied to dorsal closure in Drosophila” American Society for Cell Biology Annual Meeting, San Francisco, CA, December 2002.
  46. M.S. Hutson and G.S. Edwards, “Heat diffusion and chemical kinetics in systems with spatially-segregated domains during tunable-IR laser exposure” Biophysical Society Annual Meeting, San Francisco, CA, February 2002.
  47. M.S. Hutson, R.A. Palmer and G. Edwards, “Initial commissioning of a time-resolved FTIR beamline at the Duke Free Electron Laser Laboratory” Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Annual Meeting, Detroit, MI, October 2001.
  48. M.S. Braiman, M.S. Hutson, R.A. Krebs, S.V. Shilov, R. Parthasarathy “Time-resolved FTIR spectroscopy of halorhodopsin with site-directed isotope label at the active-site arginine” Biophysical Society Annual Meeting, Boston, MA, February 2001.
  49. R.A. Krebs, M.S. Braiman, M.S. Hutson “Modeling of the environment of the highly-conserved active-site arginine residue in the bacteriorhodopsin superfamily” Biophysical Society Annual Meeting, Boston, MA, February 2001.
  50. M.S. Hutson, R.A. Palmer, V. Litvinenko and G. Edwards, “Time-resolved infrared spectroscopy at DFELL” International Free Electron Laser Conference and FEL Users Workshop, Durham, NC, August 2000.
  51. M.S. Braiman, S.V. Shilov, M.S. Hutson “Optimizing optics, electronics, and software for biodynamical FTIR” American Chemical Society National Meeting, Washington, DC, August 2000.
  52. M.S. Braiman, M.S. Hutson, S.V. Shilov, U. Alexiev, K.J. Wise “Spectroscopic evidence for partial arginine-82 deprotonation in bacteriorhodopsin’s photocycle” American Chemical Society National Meeting, Washington, DC, August 2000.
  53. M.S. Hutson, S.V. Shilov, R. Krebs and M.S. Braiman, “Halide-dependence of halorhodopsin photocycle as measured by time-resolved FT-IR spectroscopy” Biophysical Society Annual Meeting, New Orleans, LA, Feb 2000.
  54. M.S. Hutson, K. Wise and M.S. Braiman, “Evidence for a perturbation of R82 in the bR photocycle from time-resolved FT-IR spectroscopy” Biophysical Society Annual Meeting, New Orleans, LA, Feb 2000.
  55. M.S. Hutson and M.S. Braiman, “Modeling of eukaryotic homologs of the bacteriorhodopsin superfamily reveals a potential retinoid binding site” Biophysical Society Annual Meeting, Baltimore, MD, Feb 1999.
  56. M.S. Hutson, R. Krebs and M.S. Braiman, “Application of doubled-angle phase correction method to time-resolved step-scan FT-IR spectra” Advanced Infrared and Raman Spectroscopy III, Vienna, Austria, July 1998.
  57. M.S. Hutson, A. Klingler and M.S. Braiman, “Piezoelectric-coupled diamond anvil cell” Biophysical Society Annual Meeting, New Orleans, LA, Feb 1997.
  58. L.M. Neitzey, M.S. Hutson and G. Holzwarth, “Two-dimensional motion of DNA bands during 120° pulsed-field gel electrophoresis” Biophysical Society Annual Meeting, Washington, DC, Feb 1993.

 

Other Conference Presentations

  1. E. Shannon, M.E. Lacy, M.S. Hutson, A. Page-McCaw “Calcium Dynamics as a Potential Readout of Mechanotransduction at Epithelial Wounds” 19th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease (CaBP19), Nashville, TN, June 2015.
  2. W.T. McCleery, S.M. Crews, D.N. Mashburn, J. Veldhuis, G.W. Brodland, M.S. Hutson “Finite element modeling of heat shock-induced mechanical failure in Drosophila amnioserosa” Annual Meeting of the Southeastern Section of The American Physical Society, Bowling Green, KY, November 22, 2013.
  3. M. Lacy, M.S. Hutson, A. Page-McCaw, K. LaFever “Manipulating morphogenesis with light using photoactivatable Rac1” Annual Meeting of the Southeastern Section of The American Physical Society, Bowling Green, KY, November 22, 2013.
  4. S.M. Crews, W.T. McCleery, M.S. Hutson “Stress field mapping in the amnioserosa of Drosophila embryos using laser microsurgery” Annual Meeting of the Southeastern Section of The American Physical Society, Bowling Green, KY, November 22, 2013.
  5. E.A. Copenhaver, D.M. Mashburn, M.S. Hutson “Projecting the amnioserosa into two dimensions” 121st Annual Meeting of the Ohio Academy of Science, Ashland University, Ashland, OH, April 13-14, 2012.
  6. M.P. Angarita, M.S. Hutson, X.Ma “Investigating the viscoelastic properties of fruit fly embryos with bead microrheology” SACNAS (Society for Advancement of Chicanos and Native Americans in Science) National Conference, Anaheim, CA, October 2010.
  7. H.E. Lynch, X. Ma and M.S. Hutson, “Orientation and shape dependence of embryonic wound healing” Annual Meeting of the Southeastern Section of the American Physical Society, Nashville, TN, November 2007.
  8. X. Ma and M.S. Hutson “Correlation between recoil velocity after laser ablation and cell-edge orientation” Annual Meeting of the Southeastern Section of the American Physical Society, Nashville, TN, November 2007.
  9. J. Rohner and M.S. Hutson “Cellular Potts models of fruit fly embryogenesis” Annual Meeting of the Southeastern Section of the American Physical Society, Williamsburg, VA, November 2006.
  10. G. Adunas and M.S. Hutson “Effects of IR-FEL Wavelength, Fluence and Spot size on Porcine Corneal Ablation” Annual Meeting of the Southeastern Section of the American Physical Society, Gainesville, FL, November 2005.
  11. G. Adunas, M.S. Hutson and Y. Xiao “Effects of the variation of fluence, wavelength and beam spot size in soft tissue ablation with an IR-FEL” Canadian-American-Mexican Physics Graduate Student Conference, San Diego, CA, August 2005.
  12. T. Yan and M.S. Hutson, “Microfluidic Applications in Drosophila and C. Elegans Embryogenesis” Annual Biomedical Research Conference for Minority Students (ABRCMS), Atlanta, GA, Nov 2005.
  13. M.S. Hutson, G. Adunas, X. Ma “Interplay of Fluence and Wavelength in Soft Tissue Ablation with an IR-FEL” Annual Meeting of the Southeastern Section of the American Physical Society, Oak Ridge, TN, November 2004.
  14. G. Edwards, X. Peralta, Y. Toyama, Y. Tokutake, M.S. Hutson, S. Venakides, A. Wells, D. Kiehart “Force regulation in tissue dynamics” Annual Meeting of the Southeastern Section of the American Physical Society, Oak Ridge, TN, November 2004.
  15. G. Edwards, Y. Toyama, X. Peralta, M.S. Hutson, A. Gilliken, R.A. Palmer “Electronic-vibrational spectroscopy at the Duke FEL Laboratory” Annual Meeting of the Southeastern Section of the American Physical Society, Oak Ridge, TN, November 2004.
  16. M.S. Hutson, G.D. Smith, R.A. Palmer, V. Litvinenko and G. Edwards, “Time-resolved spectroscopy at the Duke FELL” Workshop on Very Bright Infrared Sources and Applications, National Synchrotron Light Source at Brookhaven National Laboratory, Upton, NY, May 2000.

 

TEACHING

Courses Taught

Vanderbilt University
PHYS 113A – Introductory Physics for the Life Sciences, F2013-2014
Calculus-based, Newtonian Mechanics, Strong life science emphasis
PHYS 113B – Introductory Physics for the Life Sciences, S2014-2016
Calculus-based, Electricity & Magnetism, Strong life science emphasis
PHYS 117A – Introductory Physics, F2004-2006
Calculus-based, Newtonian Mechanics, Pre-med emphasis
PHYS 116B – Introductory Physics, F2010
Calculus-based, Electricity & Magnetism, Primarily engineers
PHYS 121B – General Physics, S2007
Calculus-based, Electricity & Magnetism, Prospective physics majors
PHYS/BME 325 – Physical Measurements of Biological Systems, F2003, S2006, S2008, F2009 & F2011
Elective course for graduate students in Physics, Chemistry, Biomedical Engineering
and Chemical & Physical Biology
PHYS 341 – Statistical Mechanics, S2004-2005, S2009-2012
Required core course for graduate students in Physics
Elective for graduate students in Chemical Engineering
PHYS 350 – Selected Topics: Biophysics of Pattern Formation, F2008
Elective course for graduate students in Physics, Biological Sciences and Chemical & Physical Biology
Guest Lecturer: BSCI 341 – Cell Motility, F2007-2009
Elective course for graduate students in Biological Sciences and Cell & Developmental Biology;
also taken by a few graduate students in Physics
Guest Lecturer: CBIO313 – Introduction to Modern Biological Microscopy, S2010-2012
Elective course for graduate students in Biological Sciences, Cell & Developmental Biology
and Chemical & Physical Biology

Duke University
Guest Lecturer: Inorganic Chemistry (Undergraduate), S2001 & S2002

Wake Forest University
Teaching Assistant: Introductory Physics Laboratory, S1991 & F1991
Teaching Assistant: Modern Physics Laboratory, S1992

Sylvan Learning Center, Rocky Mount & Winston-Salem, NC
Instructor: Mathematics, 1989-90, Small-group instruction of at-risk students from grades 3-12.

 

Curriculum Development

Revamped Physics 117 – Introductory, calculus-based physics for pre-med and life science majors

  • Led effort to introduce active learning strategies via Personal Response Units and peer-instruction. In Fall 2006, students achieved a mean normalized gain on the Force Concept Inventory of 0.44 (twice the typical level of student learning accomplished with traditional lectures, 0.22 ± 0.10).
  • Implemented Just-In-Time-Teaching strategies to encourage students to read material before class and to relate material to their experiences outside the classroom.
  • Implemented online homework tutorials using MasteringPhysics.
  • Organized P117 HelpDesk staffed (~30 hrs / week) both by TAs and the professors teaching each section.
  • Designed VPython-based “demonstrations” for section on thermodynamics/statistical mechanics.

Developed Physics 113A/B – Introductory Physics for the Life Sciences

  • New course aligning content and goals with new guidance on MCAT-relevant topics and the physics-related competencies delineated in the AAMC-HHMI report Scientific Foundations for Future Physicians
  • Part of a nationwide effort to redesign such IPLS courses to meet future needs for quantitative and interdisciplinary life scientists and physicians
  • Continued implementation of active learning techniques as in Physics 117 above
  • Student learning via mean normalized gain on Force Concept Inventory: 0.54 (Fall 2013), 0.49 (Fall 2014)
  • Student learning via mean normalized gain on Conceptual Survey of Electricity & Magnetism: 0.49 (Spr 2015)
  • Worked with a Graduate BOLD (Blended & Online Learning Design) Fellow to develop pre-recorded lectures and online concept mapping activities to aid students in learning electrostatics
  • Presented details of course development at 2014 American Physical Society March Meeting

 

Teaching about Teaching

  • “Active Learning in the STEM Classroom”, CIRTL (Center for the Integration of Research, Teaching and Learning) Workshop on “Evidence-Based Teaching” for Future STEM Faculty, August 24, 2015
  • Interviewee for MOOC entitled “An Introduction to Evidence-Based Undergraduate STEM Teaching,” produced by Vanderbilt Center for Teaching and CIRTL, Fall 2014; Used in Coursera MOOC and for course preview posted to YouTube: https://www.youtube.com/watch?v=lKZ6HBY3tHo
  • Panelist, “Reflections from VU Faculty on Effective Teaching”, Vanderbilt University New Faculty Orientation, August 15, 2013
  • Panelist, Center for Teaching Workshop “Engaging Students with Data and Information, Lessons from Edward Tufte” March 27, 2006
  • Panelist, Center for Teaching Workshops on “Personal Response Systems” October 4, 2004 and February 21, 2005

 

Supervisory Research Training

Postdoctoral Fellows –
Xiaoyan Ma, Physics, 2004-2011
Borislav Ivanov, Physics, 2007-2009; Research Assistant Professor with Professor C.A. Brau, Vanderbilt
Yaowu Xiao, Physics, 2004-2006; Application Scientist, Entegris, Inc.

Graduate Students – directed thesis/dissertation research
Alex Auner, Physics
Monica Lacy (NSF Graduate Research Fellow), Physics
Erica Shannon (jointly w/ Prof. Andrea Page-McCaw), Biological Sciences
W. Tyler McCleery (NSF Graduate Research Fellow), Physics
Postdoc, John Innes Centre, Norwich, England
Sarah Crews (US Dept. of Ed. GAANN Fellow), Physics, PhD 2015
Technical Staff Scientist, MIT Lincoln Laboratories, Huntsville, AL
David Mashburn, Physics, PhD 2015
Data Scientist, PluralSight Inc.
Aroshan Jayasinghe, Physics, PhD 2012
Postdoc, University of Delaware; Staff Scientist, Denovix Inc.
Holley Lynch (US Dept. of Ed. GAANN Fellow), Physics, PhD 2012
Postdoc, University of Pittsburgh
Jason Rohner, Physics, MS 2009
PhD Student in Medical Physics at East Carolina University
Tomas Yan, Biology (Fisk University), MS 2008
Educational Consultant, Vanderbilt Center for Science Outreach
Gilma Adunas, Physics, MS 2006

Graduate Students – supervised research rotation
Christian Meyer, Quantitative Chemical Biology, 2014
Abigail Searfoss, Quantitative Chemical Biology, 2013
Adam Dillman, Chemical & Physical Biology, 2011
Stacey Lawrence, Biological Sciences, 2011
Brad Robinson, Chemical & Physical Biology, 2009
Vimal Deepchand, Physics, 2006
Laurel Hoffman, Chemical & Physical Biology, 2005
Manoj Sridhar, Physics, 2003

Undergraduate Students –
Ama Agyapong, Physics (Elizabeth City St. Univ.) MARC Fellow, Sum. 2015
Grace Yook, Biophysics (Wake Forest Univ.), REU Summer 2015
Steven Pei, Physics, Spring 2015
Jason Creeden, Physics (Eastern Kentucky Univ.), REU Summer 2014
Nick Peoples, Physics (Southern Nazarene Univ.), REU Summer 2014
Cameron Togrye, Physics, Summer 2014
Nikita Lakomkin (jointly), Biological Sciences, 2014-15
Attiyya Houston, SyBBURE Summer 2013
Sam Barnett, Physics (Univ. Southern Indiana), REU Summer 2012
Eric Copenhaver, Physics (Univ. of Akron), REU Summer 2011
Karl Echiverri, Biological Sciences, Fall 2010 – Fall 2011
Paula Angarita, Physics (Florida International Univ.), REU Summer 2010
Trevor Meek, Physics (Southern Nazarene Univ.), REU Summer 2010
John Kirkham, Physics (Rhodes College), REU Summer 2009
Siri Kadire, Medicine, Health & Society, SyBBURE Summer/Fall 2009
Brett Rosenthal, Physics (Duke Univ.), REU Summer 2008
Robert Gish, Physics, REU Summer 2007, Directed Study Fall 2007
Elliott Kim, Biological Sciences, REU Summer 2007
Peter Scully, Physics, Directed Study Spring 2006
MacRae Linton, Computer Science (Duke), Summer 2006
Alanna Patsiokas (jointly), Biomedical Engineering, Senior Design Project 2004
Kevin Parker, Physics, (Duke Univ.), Summer 2003

High School Interns –
Xena McDonald (School for Science & Math at Vanderbilt), 2014
Hannah Asbell (School for Science & Math at Vanderbilt), 2010
Justine Hart, Summer 2007
Lauren Hughes, Summer 2006

PhD Committee Member (excludes students under my direct supervision, listed above) –
Hong Ni, Physics
Austin Oleskie, Chemical & Physical Biology
Jonathan Ehrman, Physics
Brittany Kamai, Physics
John Spear, Physics
Curt Kent, Mathematics
Peter Denton, Physics
Jie Zhao, Physics
Qingqing Mao, Physics, PhD 2015
Lauren Palladino, Physics, PhD 2015
Daniel Sissom, Physics, PhD 2015
Bernadette Cogswell, Physics PhD 2014
Lili Gai, Chemical Engineering, PhD 2014
Lewis Kraft, Chemical & Physical Biology, PhD 2014
Hui-Yiing Chang, Physics, PhD 2014
Alex Krejci, Physics, PhD 2013
Marc Ramsey, Mechanical Engineering, PhD 2013
Ken Lewis, Physics, PhD 2013
Jessica Mazerik, Cell & Developmental Biology, PhD 2013
Ilija Uzelac, Physics, PhD 2012
Robel Yirdaw, Physics, PhD 2012
Walter Georgescu, Biomedical Engineering, PhD 2012
Ben Lawrie, Materials Science, PhD 2011
Vimal Deepchand, Physics, MS 2010
Ben McDonald, Physics, PhD 2010
S. Reese Harry, Chemistry, PhD 2010
Heungman Park, Physics, PhD, 2010
Jonathon Jarvis, Physics, PhD 2009
Junkai Xu, Physics, PhD 2008
Stephen Johnson, Physics, PhD 2008
Mark Holcomb, Physics, PhD 2007
Andreas Werdich, Physics, PhD 2006
Michelle Baltz-Knorr, Physics, MS 2004

Undergraduate Honors Thesis Committee Member –
Patrick Diggins, Physics, 2010
Brittany Rohrman, Physics, 2009
Charles Wright, Physics, 2008
William Blake Hooper, Physics, 2007
David Mashburn, Physics, 2006
Megan Leah O’Grady, Physics, 2004

 

SERVICE

Department of Physics & Astronomy
Member, Biological Physics Search Committee, 2008-2011
Member, New Building Committee, 2010-2011
Member and Chair, Colloquium Committee, 2004-11, 2014-15 (Chair, 2006-07, 2009-11, 2014-15)
Member, Graduate Program Committee, 2003-2011, 2013-2015
Member, Undergraduate Program Committee, 2011-2012
Member and Chair, Long-Range Planning Committee, 2005-2012 (Chair 2011-2012)
Member, P&T Research Evaluation Committee, 2011, 2014
Member, P&T Teaching Evaluation Committee, 2013
Chair, Ad Hoc Review Committee for Senior Lecturer Applicants, 2012
Organizer, Mid-IR Ablation Journal Club, 2004-2005
Physics Major Advisor, 2008-Present
REU Seminar Coordinator, Summer 2007-2012, 2014-2015

College of Arts & Science
Member and Secretary, A&S Faculty Council, 2009-2011 (Secretary, 2010-2011)
Director, Program in Career Development , 2015-2017
Member, Advisory Board for Program in Career Development, 2010-2012
Member, Junior Advisory Review Committee, 2010-2011
Panelist, A&S Workshop, February 21, 2009
“Writing for Publication: Pleasures & Problems in the Academic Writing Process”
part of “Prof 101: Launching Successful Faculty Careers”
Member, AXLE Implementation Committee, 2014-2015
Member, A&S Committee on Academic Standards and Procedures, 2009-2010, 2011-2012
Member, A&S Ad Hoc Joint CASP/CEP Committee, 2009-2010

University
Member, Center for Technology Transfer and Commercialization Advisory Committee, 2013-2015
Member, Graduate Honor Fellowship Committee, 2011-2012, 2014-2015
Ad hoc reviewer, Pre-proposals for NSF Major Research Instrumentation (MRI) Program, 2014
Member, Search Committee for FEL Associate Director for Medical Applications, 2005-2006
Member, Ad hoc Studio Panel for the WM Keck Foundation’s Science and Engineering Program, 2012

Professional
Member and Chair, George B. Pegram Award Committee
(recognizing outstanding contributions to teaching physics),
Southeast Section of the American Physical Society, 2013-2014 (Chair, 2014)
Session Organizer, March Meeting of the American Physical Society, Division of Biological Physics
2009: “Biological Physics II”
2008: “General Biological Patterns”
2006: “Physical Aspects of Morphogenesis: Computational Approaches”
2006: “Biological Photophysics”
Additionally chaired at least one session each year from 2006-2011
Guest Editor, Physical Biology 5(1), March 2008
Special Focus Issue on “Physical Aspects Of Developmental Biology”
Invited Participant, National Science Foundation Workshop, June 19, 2007
“Vision and Change in Biology Undergraduate Education – A View for the 21st Century”
Reviewer of Grant Proposals –
National Institutes of Health, Member ZRG1 CB P55 Review Panel
National Science Foundation Division of Integrative Organismal Biology
Human Frontier Science Program
l’Agence Nationale de la Recherche (French National Research Agency)
European Research Council
Reviewer of Journal Articles –
Biomedical Microdevices, Biophysical Journal, Cytometry A,
Developmental Dynamics, International Journal for Numerical Methods in Biomedical Engineering,
Journal of Biomechanical Engineering, Journal of Biomedical Optics, Journal of Theoretical Biology,
Journal of Visualized Experiments (JoVE), New Journal of Physics, Optics Communications,
Optics Express, Optics Letters, Physical Biology, Physical Review Letters, Physical Review E,
Proceedings of the National Academy of Sciences U.S.A., Protein Journal,
Wound Repair and Regeneration
Participated in 2006 March Meeting Congressional Visits sponsored by American Physical Society.
Met with Rep. Jim Cooper, as well as staff members for Sen. Lamar Alexander, Rep. John Tanner and
Rep. Marsha Blackburn, to discuss the importance of federal funding for basic science research.