M. Shane Hutson

Publications

 

Refereed Journal Articles

  1. W.T. McCleery, J. Veldhuis, M.E. Bennett, H.E. Lynch, X. Ma, G.W. Brodland and M.S. Hutson (2019) “Elongated cells drive morphogenesis in a surface-wrapped finite element model of germband retraction” Biophysical Journal, in press, https://doi.org/10.1016/j.bpj.2019.05.023; highlighted in Vanderbilt News.
  2. A. Auner, K.M. Tasneem, D.A. Markov, L.J. McCawley and M.S. Hutson (2019) “Chemical-PDMS Binding Kinetics and Implications for Bioavailability in Microfluidic Devices” Lab on a Chip, 19: 864-874, https://dx.doi.org/10.1039/C8LC00796A.
  3. E.K Shannon, A. Stevens, W. Edrington, Y. Zhao, A.K Jayasinghe, A. Page-McCaw, M.S. Hutson (2017) “Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds” Biophysical Journal 113 (7): 1623-1635, https://dx.doi.org/10.1016/j.bpj.2017.07.022; highlighted in Vanderbilt News.
  4. R.G. Abramson, N. Lakomkin, A. Hainline, H. Kang, M.S. Hutson, C.L. Arteaga (2017) “The Attenuation Distribution Across the Long Axis of Breast Cancer Liver Metastases at CT: A Quantitative Biomarker for Predicting Overall Survival” American Journal of Roentgenology 210: W1-W7, https://dx.doi.org/10.2214/AJR.17.18249.
  5. M.S. Hutson, M.C.K. Leung, N.C. Baker, R.M. Spencer and T.B. Knudsen (2017) “Computational model of secondary palate fusion and disruption” Chemical Research in Toxicology 30(4): 965-979, https://dx.doi.org/10.1021/acs.chemrestox.6b00350.
  6. M.E. Lacy and M.S. Hutson (2016) “Amnioserosa development and function in Drosophila embryogenesis: critical mechanical roles for an extraembryonic tissue” Developmental Dynamics 245(5): 558-568, https://doi.org/10.1002/dvdy.24395.
  7. M.C.K. Leung, M.S. Hutson, A.W. Seifert, R.M. Spencer and T.B. Knudsen (2016) “Computational modeling and simulation of genital tubercle development” Reproductive Toxicology 64:151-61, http://dx.doi.org/10.1016/j.reprotox.2016.05.005.
  8. M.S. Hutson, P.G. Alexander, V. Allwardt, D.M. Aronoff, K.L. Bruner-Tran, D.E. Cliffel, J.M. Davidson, A. Gough, D.A. Markov, L.J. McCawley, J.R. McKenzie, J.A. McLean, K.G. Osteen, V. Pensabene, P.C. Samson, N.K. Senutovitch, S.D. Sherrod, M.S. Shotwell, D.L. Taylor, L.M. Tetz, R.S. Tuan, L.A. Vernetti and J.P. Wikswo (2016) “Organs-on-Chips as Bridges for Predictive Toxicology” Applied In Vitro Toxicology 2(2): 97-102, https://doi.org/10.1089/aivt.2016.0003.
  9. N. Lakomkin, H. Kang, B. Landman, M.S. Hutson, R.G. Abramson (2016) “The attenuation distribution across the long axis (ADLA): Preliminary findings for assessing response to cancer treatment” Academic Radiology 23(6): 718-723, http://dx.doi.org/10.1016/j.acra.2016.02.007.
  10. J. Kozub, J.-H. Shen, K.M. Joos, R. Prasad and M.S. Hutson (2015) “Optic nerve sheath fenestration using a Raman-shifted alexandrite laser”  Lasers in Surgery and Medicine 48: 270-280, http://dx.doi.org/10.1002/lsm.22456.
  11. S.M. Crews, W.T. McCleery and M.S. Hutson (2015) “Pathway to a Phenocopy: Heat Stress Effects in Early Embryogenesis” Developmental Dynamics 245: 402-413, https://doi.org/10.1002/dvdy.24360.
  12. J. Kozub, J.-H. Shen, K.M. Joos, R. Prasad and M.S. Hutson (2015) “Efficacy and predictability of soft tissue ablation using a prototype Raman-shifted alexandrite laser” Journal of Biomedical Optics 20(10): 105004 (Oct 12, 2015; 10 pp), https://doi.org/10.1117/1.JBO.20.10.105004.
  13. G. Kavanaugh, R. Zhao, Y. Guo, K.N. Mohni, G. Glick, M.E. Lacy, M.S. Hutson, M. Ascano and D. Cortez (2015) “Enhancer of Rudimentary Homolog affects the replication stress response through regulation of RNA processing” Molecular and Cellular Biology 35(17): 2979-2990, https://doi.org/10.1128/MCB.01276-14.
  14. G.W. Brodland, J.H. Veldhuis, S. Kim, M. Perrone, D. Mashburn and M.S. Hutson (2014) “CellFIT: a cellular force-inference toolkit using curvilinear cell boundaries” PLoS ONE 9: e99116 (15pp), https://doi.org/10.1371/journal.pone.0099116.
  15. H.E. Lynch, J. Veldhuis, G.W. Brodland and M.S. Hutson (2014) “Modeling cell elongation during germ band retraction: cell autonomy versus applied anisotropic stress” New Journal of Physics 16: 055003 (18pp), https://doi.org/10.1088/1367-2630/16/5/055003.
  16. Y. Yan, L. Jiang, K.J. Aufderheide, G.A. Wright, A. Terekhov, L. Costa, K. Qin, W.T. McCleery, J.J. Fellenstein, A. Ustione, J.B. Robertson, C.H. Johnson, D.W. Piston, M.S. Hutson, J.P. Wikswo, W. Hofmeister and C. Janetopoulos (2014) “A microfluidic-enabled mechanical microcompressor for the immobilization of live single- and multi-cellular specimens” Microscopy and Microanalysis 20(1): 141-151, https://doi.org/10.1017/S1431927613014037.
  17. H.E. Lynch, S.M. Crews, B. Rosenthal, E. Kim, R. Gish, K. Echiverri and M.S. Hutson (2013) “Cellular mechanics of germ band retraction in Drosophila” Developmental Biology 384: 205-213, https://doi.org/10.1016/j.ydbio.2013.10.005.
  18. A.K. Jayasinghe, S.M. Crews, D.N. Mashburn and M.S. Hutson (2013) “Apical oscillations in amnioserosa cells: basolateral coupling and mechanical autonomy” Biophysical Journal 105: 255-265, https://doi.org/10.1016/j.bpj.2013.05.027.
  19. D.N. Mashburn, H.E. Lynch, X. Ma, M.S. Hutson (2012) “Enabling user-guided segmentation and tracking of surface-labeled cells in time-lapse image sets of living tissues” Cytometry A 81A(5): 409–418. pdf
  20. M.A. Mackanos, D.M. Simanovskii, K.E. Schriver, M.S. Hutson, C.H. Contag, J.A. Kozub, E.D. Jansen (2012) “Pulse Duration Dependent Mid-Infrared Laser Ablation for Biological Applications” IEEE Journal of Selected Topics in Quantum Electronics in press (published ahead of print, 20 Feb 2012). pdf
  21. A. Jayasinghe, J. Rohner, M.S. Hutson (2011) “Holographic UV laser microsurgery” Biomedical Optics Express 2(9): 2590-2599 (cover article). pdf; animated .gif cover image.
  22. D. Azevedo, M. Antunes, S. Prag, X. Ma, U. Hacker, G.W. Brodland, M.S. Hutson, J. Solon, A. Jacinto (2011) “DRhoGEF2 Regulates Cellular Tension and Cell Pulsations in the Amnioserosa during Drosophila Dorsal Closure” PLoS One 6(9): e23964 (11pp). pdf
  23. J. Kozub, B. Ivanov, A. Jayasinghe, R. Prasad, J. Shen, M. Klosner, D. Heller, M. Mendenhall, D.W. Piston, K. Joos, M.S. Hutson (2011) “Raman-shifted alexandrite laser for soft tissue ablation in the 6- to 7-μm wavelength range” Biomedical Optics Express 2(5): 1275-1281. pdf
  24. G.W. Brodland, V. Conte, P.G. Cranston, J. Veldhuis, S. Narasimhan, M.S. Hutson, A. Jacinto, F. Ulrich, B. Baum, M. Miodownik (2010) “Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila” Proceedings of the National Academy of Sciences USA 107(51): 22111-22116 (doi: 10.1073/pnas.1006591107). pdf
  25. M.S. Hutson, J. Veldhuis, X. Ma, H.E. Lynch, P.G. Cranston, G.W. Brodland (2009) “Combining laser microsurgery and finite element modeling to assess cell-level epithelial mechanics” Biophysical Journal 97: 3075-3085 (+4 pp online supplement). pdf
  26. M.S. Hutson, B. Ivanov, A. Jayasinghe, G. Adunas, Y. Xiao, M. Guo, J. Kozub (2009) “Interplay of wavelength, fluence and spot-size in free-electron laser ablation of cornea” Optics Express 17: 9840-9850.  pdf
  27. X. Ma, H.E. Lynch, P.C. Scully, M.S. Hutson (2009) “Probing embryonic tissue mechanics with laser hole drilling” Physical Biology 6: 036004 (12pp + 2pp online supplement). pdf
  28. M.S. Hutson, G.W. Brodland, J. Yang, and D. Viens (2008) “Cell Sorting in Three Dimensions: Topology, Fluctuations, and Fluidlike Instabilities” Physical Review Letters 101: 148105 (4pp + 3pp online supplement). pdf.
  29. M.S. Hutson and X. Ma (2008) “Mechanical aspects of developmental biology: perspectives On Growth and Form in the (post)-genomic age” Physical Biology 5(1): 015001 (8pp). pdf
  30. Y. Xiao, M. Guo, P. Zhang, G. Shanmugam, P. L. Polavarapu and M. S. Hutson (2008) “Wavelength-Dependent Conformational Changes in Collagen after Mid-Infrared Laser Ablation of Cornea” Biophysical Journal 94(4): 1359-1366. pdf
  31. M. S. Hutson and X. Ma (2007) “Plasma and Cavitation Dynamics during Pulsed Laser Microsurgery in vivo”, Physical Review Letters 99(15): 158104 (4pp). pdf; featured news item in Laser Focus World (Nov 2007) and Biophotonics (Dec 2007).
  32. G.S. Edwards, R.D. Pearlstein, M.L. Copeland, M.S. Hutson, K. Latone, A. Spiro and G. Pasmanik (2007) “6450 nm wavelength tissue ablation using a nanosecond laser based on difference frequency mixing and stimulated Raman scattering” Optics Letters 32(11): 1426-1428. pdf
  33. X.G. Peralta, Y. Toyama, Y. Tokutake, M.S. Hutson, S. Venakides, D.P. Kiehart, and G.S. Edwards (2007) “Upregulation of Forces and Morphogenic Asymmetries in Dorsal Closure during Drosophila Development”, Biophysical Journal 92: 2583-2596 (+ 3pp online supplement). pdf
  34. Y. Xiao, M. Guo, K. Parker and M.S. Hutson (2006) “Wavelength-Dependent Collagen Fragmentation during Mid-IR Laser Ablation”, Biophysical Journal 91: 1424-1432. pdf
  35. Y. Xiao, M.S. Hutson, M. Belenky, J. Herzfeld, M.S. Braiman (2004) “Role of Arginine-82 in Fast Proton Release during the Bacteriorhodopsin Photocycle: A Time-Resolved FT-IR Study of Purple Membranes Containing 15N-Labeled Arginine”, Biochemistry 43: 12809-12818. pdf
  36. M.S. Hutson, Y. Tokutake, M.-S. Chang, J.W. Bloor, S. Venakides, D.P. Kiehart, G.S. Edwards (2003) “Forces for Morphogenesis Investigated with Laser Microsurgery and Quantitative Modeling” Science 300: 145-149 (+ 19pp online supplement). pdf
  37. G.S. Edwards and M.S. Hutson (2003) “Advantage of the Mark-III FEL for biophysical research and biomedical applications” Journal of Synchrotron Radiation 10: 354-357. pdf
  38. G.S. Edwards, R.H. Austin, F.E. Carroll, M.L. Copeland, M.E. Couprie, W.E. Gabella, R.F. Haglund, B.A. Hooper, M.S. Hutson, E.D. Jansen, K.M. Joos, D.P. Kiehart, I. Lindau, J. Miao, H.S. Pratisto, J.H. Shen, Y. Tokutake, A.F.G. van der Meer, A. Xie (2003) “Free-electron-laser-based biophysical and biomedical instrumentation”, Review of Scientific Instruments 74: 3207-3245. pdf
  39. M.S. Hutson, S.A. Hauger and G. Edwards (2002) “Thermal diffusion and chemical kinetics in laminar biomaterial due to heating by a free-electron laser” Physical Review E 65: 061906 (6pp). pdf
  40. M.S. Hutson, R.A. Palmer, M.-S. Chang, A. Gillikin, V. Litvinenko and G. Edwards (2002) “Commissioning of a UV/time-resolved-FTIR beamline at the Duke FEL laboratory.”Nuclear Instruments and Methods in Physics Research A 483: 560-564. pdf
  41. G.D. Smith, M.S. Hutson, Y. Lu, M.T. Tierney, M.W. Grinstaff and R.A. Palmer (2001) “Step-Scan FT-IR Time-Resolved Spectroscopy in the Solid State” Applied Spectroscopy 55: 637-642. pdf
  42. M.S. Hutson, S.V. Shilov, R. Krebs and M.S. Braiman (2001) “Halide Dependence of the Halorhodopsin Photocycle as Measured by Time-Resolved Infrared Spectra” Biophysical Journal 80: 1452-1465. pdf
  43. M.S. Hutson, U. Alexiev, S.V. Shilov, K.J. Wise and M.S. Braiman (2000) “Evidence for a Perturbation of Arginine-82 in the Bacteriorhodopsin Photocycle from Time-Resolved Infrared Spectra” Biochemistry 39: 13189-13200. pdf
  44. M.S. Hutson and M.S. Braiman (1999) “Application of doubled-angle phase correction method to time-resolved step-scan FT-IR spectra” Vibrational Spectroscopy 19: 381-385. pdf
  45. M.S. Hutson and M.S. Braiman (1998) “Direct Phase Correction of Differential FT-IR Spectra” Applied Spectroscopy 52: 974-984. pdf
  46. M.S. Hutson, G. Holzwarth, T. Duke and J. Viovy (1995) “Two-Dimensional Motion of DNA Bands During 120° Pulsed-Field Gel Electrophoresis. I. Effect of Molecular Weight.” Biopolymers 35: 297-306. pdf
  47. L.M. Neitzey, M.S. Hutson and G. Holzwarth (1993) “Two-dimensional motion of DNA bands during 120° pulsed-field gel electrophoresis.” Electrophoresis 14: 296-303. pdf

 

Book Chapters

  1. J.H. Veldhuis, D. Mashburn, M.S. Hutson, G.W. Brodland “Practical Aspects of the Cellular Force Inference Toolkit (CellFIT)”, in Methods in Cell Biology Volume 125: Biophysical Methods in Cell Biology, edited by E. Paluch, Chapter 18, pp. 331-351 (Elsevier, 2015), https://doi.org/10.1016/bs.mcb.2014.10.010.
  2. D.P. Kiehart, Y. Tokutake, M.-S. Chang, M.S. Hutson, J. Wiemann, X.G. Peralta, Y. Toyama, A.R. Wells, A. Rodriguez, and G.S. Edwards “Ultraviolet Laser Microbeam for Dissection of Drosophila Embryos”, in Cell Biology: A Laboratory Handbook, 3rd Edition, edited by J.E. Celis, Chapter 9, pp. 87-103, (Elsevier,  2006).

 

Published Conference Proceedings (Refereed)

  1. M.S. Hutson and G.S. Edwards (2004) “Advances in the Physical Understanding of Laser Surgery at 6.45 Microns”, Proceedings of the 26th International Free Electron Laser Conference and 11th FEL Users Workshop: FRAIS01. Published in JACoW (6pp). pdf

 

Published Conference Proceedings (Non-refereed)

  1. M.S. Hutson, G.W. Brodland, X. Ma, H.E. Lynch, A.K. Jayasinghe, J. Veldhuis, “Measuring and Modeling Morphogenetic Stress in Developing Embryos” in Mechanics of Biological Systems and Materials (Conference Proceedings of the Society for Experimental Mechanics) Vol. 4, pp. 107-115 (Lombard, IL, 2013), https://doi.org/10.1007/978-3-319-00777-9_15.
  2. M.S. Hutson, Y. Xiao and M. Guo, “Protein structural failure in mid-IR laser ablation of cornea” High Power Laser Ablation VI, SPIE 6261: 62612N – 10 pages (Taos, NM, May 2006), https://doi.org/10.1117/12.669004.
  3. G.S. Edwards, M.S. Hutson and S. Hauger, “Heat diffusion and chemical kinetics in Mark-III FEL tissue ablation” Commercial & Biomedical Applications of Ultrafast and Free Electron Lasers, SPIE 4633: 184-193 (San Jose, CA, 2002), https://doi.org/10.1117/12.461378.
  4. G. Edwards, M.S. Hutson, S. Hauger, J. Kozub, J. Shen, C. Shieh, K. Topadze and K. Joos, “Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns” Commercial & Biomedical Applications of Ultrafast and Free Electron Lasers, SPIE 4633: 194-201 (San Jose, CA, 2002), https://doi.org/10.1117/12.461379.
  5. M.S. Hutson, R.A. Palmer, A. Gillikin, M.-S. Chang, V.N. Litvinenko and G.S. Edwards, “UV/time-resolved FTIR beamline at the Duke FEL Laboratory” Commercial & Biomedical Applications of Ultrafast and Free Electron Lasers, SPIE 4633: 225-232 (San Jose, CA, 2002), https://doi.org/10.1117/12.461383.
  6. M. Emamian, G. Swift and M.S. Hutson “Optical beam line design for the Duke Free Electron Laser Laboratory” Proceedings of the 2001 Particle Accelerator Conference 4: 2524-2526 (Chicago, 2001), https://accelconf.web.cern.ch/accelconf/p01/PAPERS/WPPH036.PDF.
  7. G. Edwards, C. Fowler, S. Hutson, V. Litvinenko, R.A. Palmer and B. Roberts “Light source capabilities and applications research at the Duke FEL Laboratory” Biomedical Applications of Free Electron Lasers, SPIE 3925: 106-115 (San Jose, CA, 2000), https://doi.org/10.1117/12.384258

 

Editorials

  1. M.S. Hutson (2018) “Cellular Diversity Heals” Nature Physics 14: 639-641, https://doi.org/10.1038/s41567-018-0192-y.
  2. M.S. Hutson (2008) “Physical Aspects of Developmental Biology: 21st Century Perspectives On Growth and Form” Physical Biology 5(1): preface (1p), https://doi.org/10.1088/1478-3975/5/1/E01.

 

Patents

  1. K. Joos, J.-H. Shen, M.S. Hutson and J. Kozub, “Apparatus and Method for Real-Time Imaging and Monitoring of an Electrosurgical Procedure,” U.S. Patent No. 8,655,431 (Feb 2014) based on U.S. Provisional Patent Application 13/149,502 (May 2011), https://www.google.com/patents/US8655431.
  2. M.S. Hutson and G.S. Edwards, “Method and Apparatus for Infrared Tissue Ablation”, U.S. Patent No. 8,074,661 (Dec 2011) based on U.S. Provisional Patent Application #60/384,877 (May 2002), https://www.google.com/patents/US8074661.