Amritraj (Amrit) Patra
Structural Biology of Poxvirus Protein and Human Antibody Interaction
The structure of antibody-antigen complexes will be determined using single particle electron microscopy. The initial focus is to determine structures of neutralizing antibodies to orthopoxviruses bound to antigen by using X-ray crystallography and single particle electron microscopy. Computational approaches will be used to dock high resolution crystal structures of the complexed antibody and antigen into the lower resolution electron density map. The long term goal is to eventually be able to computationally predict the structure of the antibody-antigen complex once the sequence of the antibody is known.
Primary: Melanie Ohi
Secondary: Jens Meiler and Jim Crowe
Type of Trainee