Amritraj (Amrit) Patra

Structural Biology of Poxvirus Protein and Human Antibody Interaction

Project Abstract

The structure of antibody-antigen complexes will be determined using single particle electron microscopy. The initial focus is to determine structures of neutralizing antibodies to orthopoxviruses bound to antigen by using X-ray crystallography and single particle electron microscopy. Computational approaches will be used to dock high resolution crystal structures of the complexed antibody and antigen into the lower resolution electron density map. The long term goal is to eventually be able to computationally predict the structure of the antibody-antigen complex once the sequence of the antibody is known.

Project Update

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Mentors

Primary: Melanie Ohi

Secondary: Jens Meiler and Jim Crowe

Type of Trainee

Postdoctoral Fellow