Sam will work on three method development projects in year 1 of his training: 1. Introducing sequence space and somatic mutation biases into Rosetta Design. This is important to design antibodies that can be elicited with a vaccine. 2. Implement a pipeline that determines antibody sequence and structural liabilities for manufacturability and patentability. 3. Implement correlated mutations in Rosetta Design. This is important to capture correlated mutations in the heavy/light chain interface and between the complementarity determining regions (CDRs) that are important for paratope shape and conformation when designing antibodies with Rosetta.
Fast and easy antibody sequence optimization for improved expression rates by highlighting and scoring potential liabilities
Primary: Jens Meiler
Secondary: James E. Crowe, Jr.
Type of Trainee