March, 2019

Response functions estimated using conventional methods differ from the histologically derived response functions. Kernels estimated using the highest FA voxels, the iterative calibration method, and modeled from the diffusion tensor are shown in two views. The average histologically derived response function for each monkey (across 6 z stacks) is shown (monkeys 1–3 correspond to A‐C) along with the mean (red) and mean ± standard deviation (gray) surfaces to highlight variability. Note that differences in magnitude are due to differing normalization in our work and in MRTrix3. Shape, and not magnitude, determines the final FOD shape

Histologically derived fiber response functions for diffusion MRI vary across white matter fibers-An ex vivo validation study in the squirrel monkey brain.

Mar. 16, 2019—Kurt G. Schilling, Yurui Gao, Iwona Stepniewska, Vaibhav Janve, Bennett A. Landman, Adam W. Anderson. “Histologically derived fiber response functions for diffusion MRI vary across white matter fibers – an ex vivo validation study in the squirrel monkey brain”. NMR in Biomedicine. 2019 Jun;32(6):e4090. doi: 10.1002/nbm.4090. Epub 2019 Mar 25. Full text: https://www.ncbi.nlm.nih.gov/pubmed/30908803 Abstract Understanding the...